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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2000;20:1430.)
© 2000 American Heart Association, Inc.

Brief Reviews

Interactions of Oxidants With Vascular Signaling Systems

Michael S. Wolin

From the Department of Physiology, New York Medical College, Valhalla.

Correspondence to Michael S. Wolin, PhD, Department of Physiology, New York Medical College, Valhalla, NY 10595. E-mail mike wolin{at}nymc.eduwolin@nymc.edu

Abstract—Individual reactive oxygen species (ROS) and oxidation products of NO interact with vascular signaling mechanisms in ways that appear to have fundamental roles in the control of vascular physiological and pathophysiological function. The activities of ROS-producing systems (including various NADPH and NADH oxidases, xanthine oxidase, and NO synthase) in endothelium and/or vascular smooth muscle are controlled by receptor activation, oxygen tension, metabolic processes, and physiological forces associated with blood pressure and flow. This review focuses on how the chemical properties and metabolic sensing interactions of individual ROS (including superoxide anion, hydrogen peroxide, and peroxynitrite) interact with cellular regulatory systems to produce vascular responses. These species appear to often function through producing selective alterations in individual heme or thiol redox–regulated systems (including guanylate cyclase, cyclooxygenase, mitochondrial electron transport, and tyrosine phosphatases) to initiate physiological responses through signaling pathways that control phospholipases, protein kinases, ion channels, contractile proteins, and gene expression.

Key Words: oxidants • redox • signaling, vascular

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				Y. Liu, K. Terata, Q. Chai, H. Li, L. H. Kleinman, and D. D. Gutterman Peroxynitrite Inhibits Ca2+-Activated K+ Channel Activity in Smooth Muscle of Human Coronary Arterioles Circ. Res., November 29, 2002; 91(11): 1070 - 1076. [Abstract] [Full Text] [PDF]

				S. R. Clark, M. J. Coffey, R. M. Maclean, P. W. Collins, M. J. Lewis, A. R. Cross, and V. B. O'Donnell Characterization of Nitric Oxide Consumption Pathways by Normal, Chronic Granulomatous Disease and Myeloperoxidase-Deficient Human Neutrophils J. Immunol., November 15, 2002; 169(10): 5889 - 5896. [Abstract] [Full Text] [PDF]

				K. M. Channon Oxidative Stress and Coronary Plaque Stability Arterioscler Thromb Vasc Biol, November 1, 2002; 22(11): 1751 - 1752. [Full Text] [PDF]

				L. C. Hool and P. G. Arthur Decreasing Cellular Hydrogen Peroxide With Catalase Mimics the Effects of Hypoxia on the Sensitivity of the L-Type Ca2+ Channel to {beta}-Adrenergic Receptor Stimulation in Cardiac Myocytes Circ. Res., October 4, 2002; 91(7): 601 - 609. [Abstract] [Full Text] [PDF]

				R. Kohen and A. Nyska Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification Toxicol Pathol, October 1, 2002; 30(6): 620 - 650. [Abstract] [PDF]

				Z. Zhong, M. Froh, H. D. Connor, X. Li, L. O. Conzelmann, R. P. Mason, J. J. Lemasters, and R. G. Thurman Prevention of hepatic ischemia-reperfusion injury by green tea extract Am J Physiol Gastrointest Liver Physiol, October 1, 2002; 283(4): G957 - G964. [Abstract] [Full Text] [PDF]

				M. T Gewaltig and G. Kojda Vasoprotection by nitric oxide: mechanisms and therapeutic potential Cardiovasc Res, August 1, 2002; 55(2): 250 - 260. [Abstract] [Full Text] [PDF]

				F. Krotz, H. Y. Sohn, T. Gloe, S. Zahler, T. Riexinger, T. M. Schiele, B. F. Becker, K. Theisen, V. Klauss, and U. Pohl NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment Blood, July 18, 2002; 100(3): 917 - 924. [Abstract] [Full Text] [PDF]

				Z. Ungvari, A. Csiszar, Z. Bagi, and A. Koller Impaired Nitric Oxide-Mediated Flow-Induced Coronary Dilation in Hyperhomocysteinemia : Morphological and Functional Evidence for Increased Peroxynitrite Formation Am. J. Pathol., July 1, 2002; 161(1): 145 - 153. [Abstract] [Full Text] [PDF]

				H. Zheng, C. Dimayuga, A. Hudaihed, and S. D. Katz Effect of Dexrazoxane on Homocysteine-Induced Endothelial Dysfunction in Normal Subjects Arterioscler Thromb Vasc Biol, July 1, 2002; 22(7): e15 - 18. [Abstract] [Full Text] [PDF]

				E. D. Michelakis, V. Hampl, A. Nsair, X. Wu, G. Harry, A. Haromy, R. Gurtu, and S. L. Archer Diversity in Mitochondrial Function Explains Differences in Vascular Oxygen Sensing Circ. Res., June 28, 2002; 90(12): 1307 - 1315. [Abstract] [Full Text] [PDF]

				T. J. Guzik, N. E.J. West, R. Pillai, D. P. Taggart, and K. M. Channon Nitric Oxide Modulates Superoxide Release and Peroxynitrite Formation in Human Blood Vessels Hypertension, June 1, 2002; 39(6): 1088 - 1094. [Abstract] [Full Text] [PDF]

				D. M. Lenda and M. A. Boegehold Effect of a high-salt diet on oxidant enzyme activity in skeletal muscle microcirculation Am J Physiol Heart Circ Physiol, February 1, 2002; 282(2): H395 - H402. [Abstract] [Full Text] [PDF]

				Z. Bagi, Z. Ungvari, and A. Koller Xanthine Oxidase-Derived Reactive Oxygen Species Convert Flow-Induced Arteriolar Dilation to Constriction in Hyperhomocysteinemia: Possible Role of Peroxynitrite Arterioscler Thromb Vasc Biol, January 1, 2002; 22(1): 28 - 33. [Abstract] [Full Text] [PDF]

				M. Balazy, T. Iesaki, J. L. Park, H. Jiang, P. M. Kaminski, and M. S. Wolin Vicinal Nitrohydroxyeicosatrienoic Acids: Vasodilator Lipids Formed by Reaction of Nitrogen Dioxide with Arachidonic Acid J. Pharmacol. Exp. Ther., November 1, 2001; 299(2): 611 - 619. [Abstract] [Full Text] [PDF]

				S. T. Davidge Prostaglandin H Synthase and Vascular Function Circ. Res., October 12, 2001; 89(8): 650 - 660. [Abstract] [Full Text] [PDF]

				H. Cai, M. E. Davis, G. R. Drummond, and D. G. Harrison Induction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca2+/Calmodulin-Dependent Protein Kinase II/Janus Kinase 2-Dependent Pathway Arterioscler Thromb Vasc Biol, October 1, 2001; 21(10): 1571 - 1576. [Abstract] [Full Text] [PDF]

				L. J. Coppey, J. S. Gellett, E. P. Davidson, J. A. Dunlap, D. D. Lund, and M. A. Yorek Effect of Antioxidant Treatment of Streptozotocin-Induced Diabetic Rats on Endoneurial Blood Flow, Motor Nerve Conduction Velocity, and Vascular Reactivity of Epineurial Arterioles of the Sciatic Nerve Diabetes, August 1, 2001; 50(8): 1927 - 1937. [Abstract] [Full Text] [PDF]

				S.-K. Moon, L. J. Thompson, N. Madamanchi, S. Ballinger, J. Papaconstantinou, C. Horaist, M. S. Runge, and C. Patterson Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2779 - H2788. [Abstract] [Full Text] [PDF]