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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2000;20:1412.)
© 2000 American Heart Association, Inc.

Editorials

Quest for Fire

Seeking the Source of Pathogenic Oxygen Radicals in Atherosclerosis

David Schultz; David G. Harrison

From the Cardiology Division and Vascular Biology Center, Emory University School of Medicine and the Atlanta VA Medical Center, Atlanta, Ga.

Correspondence to David G. Harrison, 1639 Pierce Dr, Room 319, Woodruff Research Building, Cardiology Division, Emory University School of Medicine, Atlanta, GA 30322.

Abstract

Abstract—There is an accumulating body evidence that atherosclerosis is either caused by or accompanied by oxidative events in the vessel wall. These oxidative events have been implicated in proatherogenic modification of proteins, alteration of gene expression, promotion of inflammation, remodeling of vessels, and perturbations of vascular tone. This body of literature has led to a dogma that oxidation is a prerequisite for the atherosclerotic process. In particular, oxidation of lipoproteins by activated macrophages in the subintimal space has been postulated to be an important early step in the atherosclerotic process.

Key Words: Editorials • reactive oxygen species • superoxide • atherosclerosis • NADPH oxidases

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