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(Arteriosclerosis, Thrombosis, and Vascular Biology. 2000;20:e10.)
© 2000 American Heart Association, Inc.

ATVB Electronic Pages

Insulin-Like Growth Factor–Binding Protein-3 Is Associated With the Presence and Extent of Coronary Arteriosclerosis

Susanne Schuler-Lüttmann; Gerold Mönnig; Annette Enbergs; Helmut Schulte; Günter Breithardt; Gerd Assmann; Sebastian Kerber; Arnold von Eckardstein

From the Institut für Arterioskleroseforschung an der Universität Münster (S.S.-L., H.S., G.B., G.A., A.v.E.), the Medizinische Klinik und Poliklinik C (Kardiologie, Angiologie) (G.M., A.E., G.B., S.K.), the Institut für Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, and the Interdisziplinäres Zentrum für Klinische Forschung (IZKF), Medizinische Fakultät (A.v.E.), Westfälische Wilhelms-Universität Münster, Münster, Germany.

Correspondence to Dr Arnold von Eckardstein, Institut für Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfälische Wilhelms-Universität Münster, Albert-Schweitzer-Strasse 33, D-48149 Münster, Germany. E-mail vonecka{at}uni-muenster.de

Abstract

Abstract—Aging is associated with the progression of arteriosclerosis and the decline of several endocrine functions. We therefore investigated the association of coronary arteriosclerosis with hormones, the serum concentrations of which change during aging. Coronary angiograms of 189 men <70 years old were evaluated by 3 semiquantitative score systems to estimate the extent of focal and diffuse vessel wall alterations. Fasting sera were analyzed for levels of glucose, lipids, thyroid-stimulating hormone, insulin, insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), dehydroepiandrosterone sulfate (DHEAS), testosterone, and sex hormone–binding globulin (SHBG). After adjustment for age, body mass index, and waist-to-hip ratio, 92 patients with 1 stenoses >70% differed from 97 patients without such focal lesions by higher serum levels of glucose, total and LDL cholesterol, and apolipoprotein (apo) B, as well as by lower serum levels of IGFBP-3. Multivariate analyses revealed significant and independent correlations of all 3 coronary scores with LDL cholesterol (or apoB) and IGFBP-3; of 2 coronary scores with age, glucose, and insulin; and of 1 score with IGF-I. No significant correlations existed for waist-to-hip ratio (or body mass index) and DHEAS (or testosterone or SHBG). IGFBP-3 explained 9% to 14% and 3.5% to 10% of the variances of focal and diffuse lesions, respectively. In conclusion, IGFBP-3 and, with much less strength and consistency, insulin and IGF-I, but not markers of hypothyroidism, adrenopause, and andropause, have statistically significant and independent associations with coronary arteriosclerosis in men.

Key Words: aging • androgens • growth hormone • insulin resistance • quantitative coronary angiography

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