Arteriosclerosis, Thrombosis, and Vascular Biology. 2000;20:1052-1056
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© 2000 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Serum C-Reactive Protein and Self-Reported Stroke
Findings From the Third National Health and Nutrition Examination Survey
From the Division of Nutrition and Physical Activity and the Division of Adult Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga.
Correspondence to Earl Ford, MD, MPH, Division of Nutrition, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, MS K26, Atlanta, GA 30341. E-mail esf2{at}cdc.gov
Abstract—C-reactive protein may
predict the risk of coronary heart disease, but its association
with stroke has not been well studied. We used data from the Third
National Health and Nutrition Examination Survey, conducted from 1988
to 1994, to examine the association between serum C-reactive protein
concentrations and self-reported past history of stroke among 8850 US
men and women aged 
40 years. The unadjusted geometric mean of
C-reactive protein concentration was higher among participants with
stroke than those without stroke (0.45±0.02 versus 0.32±0.01,
P<0.001). After adjusting for age, sex, race or
ethnicity, education, smoking status, systolic blood pressure,
serum cholesterol, high density lipoprotein
cholesterol, history of diabetes mellitus, body mass index,
and physical activity, the odds ratio for stroke among participants
with C-reactive protein concentrations 0.55 mg/dL compared with
participants with concentrations 
0.21 mg/dL was 1.71 (95% CI 1.11 to
2.64 [odds ratio per mg/dL 1.19, 95% CI 1.05 to 1.34]). These
cross-sectional data support findings from other studies suggesting
that C-reactive protein concentration may be a risk factor or marker
for stroke in the US population.
Key Words: cerebrovascular diseases • C-reactive protein • cross-sectional studies • health surveys • risk factors
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