© 2000 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Segregation Analysis of Apolipoproteins A-1 and B-100 Measured Before and After an Exercise Training Program
The HERITAGE Family Study
From the Division of Biostatistics (P.A., T.R., I.B.B., D.C.R.) and Department of Genetics and Psychiatry (D.C.R.), Washington University School of Medicine, St Louis, Mo; Laboratory of Molecular Endocrinology, CHUL Research Center (J.G.) and Lipid Research Center (J.B., J.-P.D.), Laval University, Québec, Canada; School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis (A.S.L.); Department of Kinesiology, Indiana University, Bloomington (J.S.S.); Department of Health and Kinesiology, Texas A&M University, College Station (J.H.W.); and Pennington Biomedical Research Center, Louisiana State University, Baton Rouge (C.B.).
Correspondence to Ping An, MD, Division of Biostatistics, Campus Box 8067, Washington University School of Medicine, 660 S Euclid Ave, St Louis, Mo 63110-1093. E-mail anping{at}wubios.wustl.edu
Abstract—Complex segregation
analyses of apolipoproteins (apo) A-1 and B-100 were performed
in a sample of 520 individuals from 99 white families who participated
in the HERITAGE Family Study. In these sedentary families, plasma apo
A-1 and B-100 concentrations were measured before and after a 20-week
endurance exercise training program. Baseline apo A-1 and B-100 were
adjusted for the effects of age (age-adjusted baseline apo A-1 and
B-100) and for the effects of age and BMI (age-BMI–adjusted baseline
apo A-1 and B-100). The change in response to training was computed as
a simple 
(posttraining minus baseline) and was adjusted for age and
the baseline (age-baseline–adjusted apo A-1 and B-100 responses to
training). In the present study, a major gene could not be inferred
for baseline apo A-1. Rather, we found a major effect along with a
multifactorial effect accounting for 8% to 9% and 51% to 56% of the
variance, respectively. In addition, no clear evidence supported a
major-gene effect for its response to training, whereas the
transmission of a major effect from parents to offspring was ambiguous,
ie, genetic in nature or familial environmental in origin. The major
effect accounted for 15% of the variance, with an additional 21% and
58% of the variance being accounted for by a multifactorial effect in
parents and offspring, respectively. It is interesting to have obtained
evidence of a putative recessive major locus for baseline apo B-100,
which accounted for 50% to 56% of the variance, with an additional
25% to 29% of the variance due to a multifactorial effect. In
contrast, no major effect for its response to training was identified,
although a multifactorial effect was found that accounted for 27% of
the variance. The novel findings arising from the present study are
summarized as follows. Baseline apo A-1 and its response to training
were influenced by a major effect and a multifactorial effect. Baseline
apo B-100 was influenced by a putative major recessive gene with a
multifactorial component, but its response to training was influenced
solely by a multifactorial component in these sedentary families.
Key Words: commingling • major gene effect • major effect • multifactorial effect
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