© 2000 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Antibodies Against Oxidized LDL and Carotid Artery Intima-Media Thickness in a Healthy Population
From the Second Department of Internal Medicine (M.F., T.S., M.E., T.K., Y.N.) and the Department of Cardiovascular Medicine, Institute of Geriatrics and Medical Science (Y.O.), Osaka City University Medical School, Osaka, Japan.
Correspondence to Tetsuo Shoji, MD, Second Department of Internal Medicine, Osaka City University Medical School, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. E-mail t-shoji{at}med.osaka-cu.ac.jp
Abstract—Oxidation of LDLs plays an important role in atherosclerosis, and immune response to oxidized LDL (oxLDL) may modulate atherogenesis. Although immunization with oxLDL is shown to suppress atherogenesis in animal models, the role of the immune response to oxLDL is not well established in humans. We investigated the relationship between the titer of anti-oxLDL antibody (oxLDL Ab) and arterial wall thickness in a healthy population with no clinical signs of atherosclerosis. Intima-media thickness of the carotid arteries (CA-IMT) was measured by high-resolution B-mode ultrasonography in 446 healthy subjects. The titer of IgG-class oxLDL Ab was measured by a solid-phase ELISA. In univariate analysis, CA-IMT correlated positively with age, systolic blood pressure, total cholesterol, triglyceride, LDL cholesterol, body mass index, and waist-to-hip ratio, whereas it correlated negatively with HDL cholesterol and oxLDL Ab titer. The inverse association between oxLDL Ab titer and CA-IMT remained significant in multiple regression analysis, which took other confounding variables into account. These results indicate an independent inverse relationship between oxLDL Ab titer and CA-IMT in healthy subjects, supporting the hypothesis that immune response to oxLDL may have a protective role at an early stage of human atherosclerosis.
Key Words: oxidized LDL • anti-oxidized LDL antibody • immunoglobulin • atherosclerosis • intima-media thickness
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