Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Arteriosclerosis, Thrombosis, and Vascular Biology. 1982;2:493-499

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stender, S.
Right arrow Articles by Zilversmit, D. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stender, S.
Right arrow Articles by Zilversmit, D. B.

Arteriosclerosis, Vol 2, 493-499, Copyright © 1982 by American Heart Association

ARTICLES

Comparison of cholesteryl ester transfer from chylomicrons and other plasma lipoproteins to aortic intima media of cholesterol-fed rabbits

S Stender and DB Zilversmit

Lymph chylomicrons labeled with 14C-cholesterol and plasma very low and intermediate density lipoproteins (d less than 1.019) labeled with 3H- cholesterol were injected simultaneously into recipient cholesterol-fed rabbits. The cholesteryl ester of chylomicron origin (14C) found in the tissues 1 to 4 hours after the injection is the sum of both direct and indirect uptake of chylomicron cholesteryl ester. The direct uptake of chylomicron cholesteryl ester is defined as occurring in situ during the interaction between chylomicrons and lipoprotein lipase in endothelial cells. The indirect uptake of chylomicron cholesteryl ester results from the uptake of chylomicron remnants and of other plasma lipoproteins which become labeled during the degradation of the injected chylomicrons by net lipid transfer or by exchange. The indirect contribution of chylomicron cholesteryl ester to tissues was calculated from tissue 3H-cholesteryl ester derived from injected plasma d less than 1.019 lipoproteins. In rabbits fed 0.5 g cholesterol daily for 40-60 days, with plasma cholesterol concentrations between 20 and 30 mM (800-1200 mg/dl), less than 1% of the cholesteryl ester influx into aortic intima media and less than 10% in liver was derived from the direct uptake of chylomicron cholesteryl ester.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
M. Weintraub, I. Grosskopf, Y. Trostanesky, G. Charach, A. Rubinstein, and N. Stern
Thyroxine Replacement Therapy Enhances Clearance of Chylomicron Remnants in Patients with Hypothyroidism
J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2532 - 2536.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
B. H. Chung, F. Franklin, B. H. S. Cho, J. P. Segrest, K. Hart, and B. E. Darnell
Potencies of Lipoproteins in Fasting and Postprandial Plasma to Accept Additional Cholesterol Molecules Released From Cell Membranes
Arterioscler. Thromb. Vasc. Biol., August 1, 1998; 18(8): 1217 - 1230.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
M. S Weintraub, I. Grosskopf, T. Rassin, H. Miller, G. Charach, H. H Rotmensch, M. Liron, A. Rubinstein, and A. Iaina
Clearance of chylomicron remnants in normolipidaemic patients with coronary artery disease: case control study over three years
BMJ, April 13, 1996; 312(7036): 935 - 939.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. Jeppesen, C. B. Hollenbeck, M.-Y. Zhou, A. M. Coulston, C. Jones, Y.-D. I. Chen, and G. M. Reaven
Relation Between Insulin Resistance, Hyperinsulinemia, Postheparin Plasma Lipoprotein Lipase Activity, and Postprandial Lipemia
Arterioscler. Thromb. Vasc. Biol., March 1, 1995; 15(3): 320 - 324.
[Abstract] [Full Text]


ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1982 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.