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(Circulation. 1950;2:705.)
© 1950 American Heart Association, Inc.

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Production of Experimental Cholesterol-Induced Atherosclerosis in Chicks with Minimal Hypercholesterolemia and Organ Lipidosis

J. STAMLER M.D.¹; L. N. KATZ M.D.¹; C. Bolene ¹

¹ From the Cardiovascular Department, Medical Research Institute, Michael Reese Hospital, Chicago, Ill.

Feeding chicks a mash enriched with 0.25 per cent cholesterol plus 5 per cent cottonseed oil induces a minimal sustained hypercholesterolemia. After 35 weeks of this regimen, birds exhibited a high incidence of gross cholesterol-induced atherosclerosis, particularly prominent in the thoracic aorta. The presence of atherosclerosis in these chicks with minimal diet-induced hypercholesterolemia lends further experimental support to the concept of the relationship of cholesterol in general, and exogenous cholesterol in particular, to the pathogenesis of human atherosclerosis.

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