© 1999 American Heart Association, Inc.
Vascular Biology |
Adenovirus-Mediated Overexpression of c-Jun and c-Fos Induces Intercellular Adhesion Molecule-1 and Monocyte Chemoattractant Protein-1 in Human Endothelial Cells
From the Division of Biomedical Sciences (N.W., L.V., Y.Z., M.B.S.), University of California, Riverside; Chiron Corp (S.H.), Emerville; and Elan Pharmaceuticals (J.F.), Menlo Park, Calif.
Correspondence to M.B. Stemerman, MD, Division of Biomedical Sciences, University of California, Riverside, CA 92521. E-mail michael.stemerman{at}ucr.edu
Abstract—As distal targets and mediators of signal
transduction pathways, activator protein-1 (AP-1), c-Jun,
and c-Fos are among the primary regulators of genes involved in cell
function, proliferation, and differentiation. By using
adenovirus-mediated gene transfer, we show that overexpression of AP-1
proteins directly causes coinduction of gene expression of an adhesion
molecule, intercellular adhesion molecule-1 (ICAM-1), and a chemokine,
monocyte chemoattractant protein-1 (MCP-1), in human vascular
endothelial cells (ECs). The AP-1–induced gene
expression occurs through a mechanism independent of nuclear
factor-
B. Because the induced expression of ICAM-1 and MCP-1 in ECs
has been implicated in endothelial activation and a
number of important vascular disorders, it is suggested that AP-1
activation may play an important role in the pathogeneses of
inflammation, angiogenesis, and
atherogenesis.
Key Words: endothelial activation • AP-1 • adenovirus • adhesion molecules • chemokines
This article has been cited by other articles:
 |
|
 |
|
  S. Wolter, A. Doerrie, A. Weber, H. Schneider, E. Hoffmann, J. von der Ohe, L. Bakiri, E. F. Wagner, K. Resch, and M. Kracht c-Jun Controls Histone Modifications, NF-{kappa}B Recruitment, and RNA Polymerase II Function To Activate the ccl2 Gene Mol. Cell. Biol., July 1, 2008; 28(13): 4407 - 4423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Liu, H. van Goor, R. Havinga, J. F. W. Baller, V. W. Bloks, F. R. van der Leij, P. J. J. Sauer, F. Kuipers, G. Navis, and M. H. de Borst Neonatal dexamethasone administration causes progressive renal damage due to induction of an early inflammatory response Am J Physiol Renal Physiol, April 1, 2008; 294(4): F768 - F776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. H. Woo, Y. L. Siow, and K. O Homocysteine Induces Monocyte Chemoattractant Protein-1 Expression in Hepatocytes Mediated via Activator Protein-1 Activation J. Biol. Chem., January 18, 2008; 283(3): 1282 - 1292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. T. Yuen, S.-K. Jo, M. K. Holly, X. Hu, and R. A. Star Ischemic and nephrotoxic acute renal failure are distinguished by their broad transcriptomic responses Physiol Genomics, May 16, 2006; 25(3): 375 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-M. Bian, S. G. Elner, A. Yoshida, and V. M. Elner Differential Involvement of Phosphoinositide 3-Kinase/Akt in Human RPE MCP-1 and IL-8 Expression Invest. Ophthalmol. Vis. Sci., June 1, 2004; 45(6): 1887 - 1896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Nadruz Jr., C. B. Kobarg, J. Kobarg, and K. G. Franchini c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H760 - H767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Dagia and D. J. Goetz A proteasome inhibitor reduces concurrent, sequential, and long-term IL-1{beta}- and TNF-{alpha}-induced ECAM expression and adhesion Am J Physiol Cell Physiol, October 1, 2003; 285(4): C813 - C822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-W. Chen, Y.-H. Chen, F.-Y. Lin, Y.-L. Chen, and S.-J. Lin Ginkgo biloba Extract Inhibits Tumor Necrosis Factor-{alpha}-Induced Reactive Oxygen Species Generation, Transcription Factor Activation, and Cell Adhesion Molecule Expression in Human Aortic Endothelial Cells Arterioscler. Thromb. Vasc. Biol., September 1, 2003; 23(9): 1559 - 1566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wang, L. Verna, N.-G. Chen, J. Chen, H. Li, B. M. Forman, and M. B. Stemerman Constitutive Activation of Peroxisome Proliferator-activated Receptor-gamma Suppresses Pro-inflammatory Adhesion Molecules in Human Vascular Endothelial Cells J. Biol. Chem., September 6, 2002; 277(37): 34176 - 34181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N.-H. Cho, S.-Y. Seong, M.-S. Huh, N.-H. Kim, M.-s. Choi, and I.-s. Kim Induction of the Gene Encoding Macrophage Chemoattractant Protein 1 by Orientia tsutsugamushi in Human Endothelial Cells Involves Activation of Transcription Factor Activator Protein 1 Infect. Immun., September 1, 2002; 70(9): 4841 - 4850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Masamune, K. Kikuta, M. Satoh, A. Satoh, and T. Shimosegawa Alcohol Activates Activator Protein-1 and Mitogen-Activated Protein Kinases in Rat Pancreatic Stellate Cells J. Pharmacol. Exp. Ther., July 1, 2002; 302(1): 36 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wang, L. Verna, H.-l. Liao, A. Ballard, Y. Zhu, and M. B. Stemerman Adenovirus-Mediated Overexpression of Dominant-Negative Mutant of c-Jun Prevents Intercellular Adhesion Molecule-1 Induction by LDL: A Critical Role for Activator Protein-1 in Endothelial Activation Arterioscler. Thromb. Vasc. Biol., September 1, 2001; 21(9): 1414 - 1420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-L. Chang, J.-J. Shen, B.-S. Wung, J.-J. Cheng, and D. L. Wang Chinese Herbal Remedy Wogonin Inhibits Monocyte Chemotactic Protein-1 Gene Expression in Human Endothelial Cells Mol. Pharmacol., September 1, 2001; 60(3): 507 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhu, H. Liao, N. Wang, K.-S. Ma, L. K. Verna, J. Y.-J. Shyy, S. Chien, and M. B. Stemerman LDL-Activated p38 in Endothelial Cells Is Mediated by Ras Arterioscler. Thromb. Vasc. Biol., July 1, 2001; 21(7): 1159 - 1164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Wang, Y. L. Siow, and K. O Homocysteine induces monocyte chemoattractant protein-1 expression by activating NF-{kappa}B in THP-1 macrophages Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2840 - H2847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N.-H. Cho, S.-Y. Seong, M.-S. Choi, and I.-S. Kim Expression of Chemokine Genes in Human Dermal Microvascular Endothelial Cell Lines Infected with Orientia tsutsugamushi Infect. Immun., March 1, 2001; 69(3): 1265 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Stockinger, C. Brandes, D. Fasching, M. Hermann, M. Gotthardt, J. Herz, W. J. Schneider, and J. Nimpf The Reelin Receptor ApoER2 Recruits JNK-interacting Proteins-1 and -2 J. Biol. Chem., August 11, 2000; 275(33): 25625 - 25632. [Abstract] [Full Text] [PDF]
|
|