© 1999 American Heart Association, Inc.
Vascular Biology |
Cross-Sectional Study of Soluble Intercellular Adhesion Molecule-1 and Cardiovascular Risk Factors in Apparently Healthy Men
From the Cardiovascular Division (L.E.P.R., P.M.R.), and the Division of Preventive Medicine (C.H.H., P.M.R.), Brigham and Women's Hospital; and the Department of Ambulatory Care and Prevention (C.H.H.), Harvard Medical School, Boston, Mass.
Correspondence to Paul M. Ridker, MD, Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115. E-mail pmridker{at}bics.bwh.harvard.edu
Abstract—An elevated plasma
concentration of the soluble intercellular adhesion molecule-1
(sICAM-1) is associated with increased risk for future coronary
events. However, data exploring the interrelations of sICAM-1 with
known cardiovascular risk factors are sparse. We
determined sICAM-1 levels in 948 middle-aged men with no prior history
of cardiovascular disease. sICAM-1 levels increased
with age (P<0.001) and were significantly associated
with smoking (P<0.001), hypertension
(P<0.05), and frequent alcohol consumption
(P=0.006). Positive correlations were observed between
sICAM-1 and triglycerides (r=0.15;
P<0.001), fibrinogen (r=0.21;
P<0.001), tissue-type plasminogen
activator antigen (r=0.17;
P<0.001), and total homocysteine
(r=0.09; P=0.02); whereas a negative
correlation was observed for high density lipoprotein
cholesterol (r=-0.15;
P<0.001). Overall, plasma concentrations of sICAM-1
increased with increasing prevalence of usual
cardiovascular risk factors; mean plasma concentrations
were 231, 236, 245, 257, and 312 ng/mL for those subjects with 0, 1, 2,
3, and >4 risk factors, respectively (P<0.01 for
trend). In multivariate analysis, age, smoking
status, diabetes, systolic blood pressure, positive family
history of coronary disease, and serum levels of total
homocysteine and fibrinogen were all independently associated with
sICAM-1 levels (all P
0.05). sICAM-1 levels are
associated with several established cardiovascular risk
factors. Further studies will be needed to evaluate whether these
associations reflect the role of sICAM-1 as a marker of preclinical
atherosclerosis, and whether such interrelations might
have a causal basis.
Key Words: adhesion molecules • inflammation • risk factors • atherosclerosis
This article has been cited by other articles:
 |
|
 |
|
  S. Hong, R. A. Nelesen, P. L. Krohn, P. J. Mills, and J. E. Dimsdale The Association of Social Status and Blood Pressure With Markers of Vascular Inflammation Psychosom Med, July 1, 2006; 68(4): 517 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Okapcova and D. Gabor The Levels of Soluble Adhesion Molecules in Diabetic and Nondiabetic Patients with Combined Hyperlipoproteinemia and the Effect of Ciprofibrate Therapy Angiology, November 1, 2004; 55(6): 629 - 639. [Abstract] [PDF]
|
|
|
|
|
|
J. Okapcova and D. Gabor The Levels of Soluble Adhesion Molecules in Diabetic and Nondiabetic Patients with Combined Hyperlipoproteinemia and the Effect of Ciprofibrate Therapy Angiology, November 1, 2004; 55(6): 629 - 639. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Stocker and J. F. Keaney Jr. Role of Oxidative Modifications in Atherosclerosis Physiol Rev, October 1, 2004; 84(4): 1381 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Keaney Jr, J. M. Massaro, M. G. Larson, R. S. Vasan, P. W. F. Wilson, I. Lipinska, D. Corey, P. Sutherland, J. A. Vita, and E. J. Benjamin Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study J. Am. Coll. Cardiol., July 7, 2004; 44(1): 168 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Sardo, M. Castaldo, M. Cinquegrani, M. Bonaiuto, L. Fontana, S. Campo, G. M. Campo, D. Altavilla, and A. Saitta Effects of AT1 Receptor Antagonist Losartan on sICAM-1 and TNF-a Levels in Uncomplicated Hypertensive Patients Angiology, March 1, 2004; 55(2): 195 - 203. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Hassan, B. J. Hunt, M. O'Sullivan, R. Bell, R. D'Souza, S. Jeffery, J. M. Bamford, and H. S. Markus Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction Brain, January 1, 2004; 127(1): 212 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Lindsberg and A. J. Grau Inflammation and Infections as Risk Factors for Ischemic Stroke Stroke, October 1, 2003; 34(10): 2518 - 2532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tanne, M. Haim, V. Boyko, U. Goldbourt, T. Reshef, S. Matetzky, Y. Adler, Y. A. Mekori, and S. Behar Soluble Intercellular Adhesion Molecule-1 and Risk of Future Ischemic Stroke: A Nested Case-Control Study From the Bezafibrate Infarction Prevention (BIP) Study Cohort Stroke, September 1, 2002; 33(9): 2182 - 2186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Koh Effects of estrogen on the vascular wall: vasomotor function and inflammation Cardiovasc Res, September 1, 2002; 55(4): 714 - 726. [Full Text] [PDF]
|
|
|
|
|
|
K. Kohara, Y. Tabara, Y. Yamamoto, M. Igase, and T. Miki Chlamydia pneumoniae Seropositivity Is Associated With Increased Plasma Levels of Soluble Cellular Adhesion Molecules in Community-Dwelling Subjects: The Shimanami Health Promoting Program (J-SHIPP) Study Stroke, June 1, 2002; 33(6): 1474 - 1479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Silverman, R. J. Tumuluri, M. Davis, G. Lopez, J. T. Rosenbaum, and P. I. Lelkes Homocysteine Upregulates Vascular Cell Adhesion Molecule-1 Expression in Cultured Human Aortic Endothelial Cells and Enhances Monocyte Adhesion Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 587 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Targher, R. C. Bonadonna, M. Alberiche, M. B. Zenere, M. Muggeo, and E. Bonora Relation Between Soluble Adhesion Molecules and Insulin Sensitivity in Type 2 Diabetic Individuals: Role of adipose tissue Diabetes Care, November 1, 2001; 24(11): 1961 - 1966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Hak, H. A. P. Pols, C. D. A. Stehouwer, J. Meijer, A. J. Kiliaan, A. Hofman, M. M. B. Breteler, and J. C. M. Witteman Markers of Inflammation and Cellular Adhesion Molecules in Relation to Insulin Resistance in Nondiabetic Elderly: The Rotterdam Study J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4398 - 4405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Labarrere, D. R. Nelson, S. J. Miller, J. M. Nieto, J. A. Conner, D. E. Pitts, P. C. Kirlin, and H. G. Halbrook Value of Serum-Soluble Intercellular Adhesion Molecule-1 for the Noninvasive Risk Assessment of Transplant Coronary Artery Disease, Posttransplant Ischemic Events, and Cardiac Graft Failure Circulation, September 26, 2000; 102(13): 1549 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Silverman, R. J. Tumuluri, M. Davis, G. Lopez, J. T. Rosenbaum, and P. I. Lelkes Homocysteine Upregulates Vascular Cell Adhesion Molecule-1 Expression in Cultured Human Aortic Endothelial Cells and Enhances Monocyte Adhesion Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 587 - 592. [Abstract] [Full Text] [PDF]
|
|