This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Morange, P. E. Articles by Juhan-Vague, I. Search for Related Content PubMed PubMed Citation Articles by Morange, P. E. Articles by Juhan-Vague, I. Related Collections Lipids Growth factors/cytokines Coagulation and fibronolysis

(Arteriosclerosis, Thrombosis, and Vascular Biology. 1999;19:1361-1365.)
© 1999 American Heart Association, Inc.

Thrombosis

PAI-1 Produced Ex Vivo by Human Adipose Tissue Is Relevant to PAI-1 Blood Level

P. E. Morange; M. C. Alessi; M. Verdier; D. Casanova; G. Magalon; I. Juhan-Vague

From the Laboratory of Hematology, CHU Timone (P.E.M., M.C.A., M.V., I.J.-V.), and the Department of Plastic Surgery, CHU Conception (D.C., G.M.), Marseille, France.

Correspondence to Pr I. Juhan-Vague, Laboratory of Hematology, CHU Timone, 13385 Marseille Cedex 5, France.

Abstract—Human adipose tissue has been shown to produce plasminogen activator inhibitor type 1 (PAI-1). However, the importance of adipose tissue in the regulation of the PAI-1 plasma level is not known. The aim of this study was to investigate the relation between the production of PAI-1 by adipose tissue, plasma PAI-1 level, and variables related to the insulin resistance state. The link between the production of PAI-1 inducers such as tumor necrosis factor- and transforming growth factor-ß and the production of PAI-1 by adipose tissue was also evaluated. Blood samples were obtained as soon as possible to the induction of anesthesia from 30 patients undergoing elective abdominoplasty. PAI-1 antigen levels measured in conditioned media after a 19-hour incubation period of adipose tissue explants were significantly correlated with plasma PAI-1 antigen levels (r=0.54, P=0.004) and with systemic lipid parameters such as triglycerides and high density lipoprotein cholesterol (r=0.46, P=0.014; r=-0.50, P=0.01, respectively) but not with insulinemia and body mass index. PAI-1 production by adipose tissue was correlated with those of TNF- (r=0.5, P=0.01) and TGF-ß (r=0.53, P=0.007). These results emphasize the role of adipose tissue in determining plasma levels of PAI-1, with a local contribution of TNF- and TGF-ß in PAI-1 production by adipose tissue.

Key Words: PAI-1 • humans • adipose tissue • TNF- • TGF-ß

This article has been cited by other articles:

				P. F. Bodary Links Between Adipose Tissue and Thrombosis in the Mouse Arterioscler Thromb Vasc Biol, November 1, 2007; 27(11): 2284 - 2291. [Abstract] [Full Text] [PDF]

				M. L.G. Correia and W. G. Haynes A Role for Plasminogen Activator Inhibitor-1 in Obesity: From Pie to PAI? Arterioscler Thromb Vasc Biol, October 1, 2006; 26(10): 2183 - 2185. [Full Text] [PDF]

				A. M. Kanaya, C. Wassel Fyr, E. Vittinghoff, T. B. Harris, S. W. Park, B. H. Goodpaster, F. Tylavsky, and S. R. Cummings Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1. Arch Intern Med, February 13, 2006; 166(3): 350 - 356. [Abstract] [Full Text] [PDF]

				T. Kurth, J. M. Gaziano, K. M. Rexrode, C. S. Kase, N. R. Cook, J. E. Manson, and J. E. Buring Prospective Study of Body Mass Index and Risk of Stroke in Apparently Healthy Women Circulation, April 19, 2005; 111(15): 1992 - 1998. [Abstract] [Full Text] [PDF]

				M. Romano, M. T. Guagnano, G. Pacini, S. Vigneri, A. Falco, M. Marinopiccoli, M. R. Manigrasso, S. Basili, and G. Davi Association of Inflammation Markers with Impaired Insulin Sensitivity and Coagulative Activation in Obese Healthy Women J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5321 - 5326. [Abstract] [Full Text] [PDF]

				H. Yki-Jarvinen, J. Sutinen, A. Silveira, E. Korsheninnikova, R. M. Fisher, K. Kannisto, E. Ehrenborg, P. Eriksson, and A. Hamsten Regulation of Plasma PAI-1 Concentrations in HAART-Associated Lipodystrophy During Rosiglitazone Therapy Arterioscler Thromb Vasc Biol, April 1, 2003; 23(4): 688 - 694. [Abstract] [Full Text] [PDF]

				H. R. Lijnen, E. Maquoi, P. Morange, G. Voros, B. Van Hoef, F. Kopp, D. Collen, I. Juhan-Vague, and M.-C. Alessi Nutritionally Induced Obesity Is Attenuated in Transgenic Mice Overexpressing Plasminogen Activator Inhibitor-1 Arterioscler Thromb Vasc Biol, January 1, 2003; 23(1): 78 - 84. [Abstract] [Full Text] [PDF]

				T. Kurth, J. M. Gaziano, K. Berger, C. S. Kase, K. M. Rexrode, N. R. Cook, J. E. Buring, and J. E. Manson Body Mass Index and the Risk of Stroke in Men Arch Intern Med, December 9, 2002; 162(22): 2557 - 2562. [Abstract] [Full Text] [PDF]

				C. Perry, N. Sattar, and J. Petrie Review: Adipose tissue: passive sump or active pump? The British Journal of Diabetes & Vascular Disease, November 1, 2001; 1(2): 110 - 114. [Abstract] [PDF]