© 1999 American Heart Association, Inc.
Original Contributions |
Increased Plasma 7ß-Hydroxycholesterol Concentrations in a Population With a High Risk for Cardiovascular Disease
From the Department of Physiology and Biochemistry (A.K., Z.K.), Faculty of Medicine, Vilnius, Lithuania; the Department of Health and Environment (M.K.), Faculty of Health Sciences, and the Department of Medicine and Care and Clinical Research Center (B.Z., A.G.O.), Faculty of Health Sciences, Linköping; the Department of Geriatrics (B.V.), Uppsala University, Uppsala; and the Department of Medical Laboratory Sciences and Technology (U.D.), Division of Clinical Chemistry, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden.
Correspondence to Bo Ziedén, Clinical Research Center and Department of Medicine and Care, Faculty of Health Sciences, S-581 85 Linköping, Sweden. E-mail Bo.Zieden{at}kfc.liu.se
Abstract—The mortality in
coronary heart disease among 50- to 54-year-old men is 4 times
higher in Lithuania than in Sweden. It was recently suggested that
traditional risk factors could not explain this mortality difference.
LDL of Lithuanian men showed, however, a lower resistance to oxidation
than that of Swedish men. In addition, the plasma concentration of
-tocopherol, lycopene, and ß-carotene were lower in
Lithuanian men. In the present investigation, we determined plasma
oxysterols in men from Lithuania and Sweden and found that the plasma
concentration of 7ß-hydroxycholesterol was higher in
Lithuanian men, 12±5 versus 9±8 (SD) ng/mL (P=0.0011).
This oxysterol is a cholesterol autoxidation product
and there is no indication that it should have an enzymatic origin.
Mean LDL oxidation lag time was shorter in Lithuanian men (75±14
versus 90±13 minutes, P<0.0001) and the concentration
of LDL linoleic acid was lower (249±56 versus 292±54 µg/mg of LDL
protein, P<0.0001). Lipid corrected
-tocopherol was 0.07±0.02 mg/mL in Vilnius men and
0.12±0.04 mg/mL (P<0.0001) in Linköping men.
There was a negative correlation between the concentration of
7ß-hydroxycholesterol and lag time
(R=-0.31, P=0.0023). It is
suggested that the higher 7ß-hydroxycholesterol
concentration in Lithuanian men is an indication of an increased in
vivo lipid peroxidation.
Key Words: oxysterols • LDL oxidation • vitamins • fatty acids • cross-sectional study
This article has been cited by other articles:
 |
|
 |
|
  M. Wamil, R. Andrew, K. E. Chapman, J. Street, N. M. Morton, and J. R. Seckl 7-Oxysterols Modulate Glucocorticoid Activity in Adipocytes through Competition for 11{beta}-Hydroxysteroid Dehydrogenase Type Endocrinology, December 1, 2008; 149(12): 5909 - 5918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Alkazemi, G. Egeland, J. Vaya, S. Meltzer, and S. Kubow Oxysterol as a Marker of Atherogenic Dyslipidemia in Adolescence J. Clin. Endocrinol. Metab., November 1, 2008; 93(11): 4282 - 4289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Staprans, X.-M. Pan, J. H. Rapp, A. H. Moser, and K. R. Feingold Ezetimibe inhibits the incorporation of dietary oxidized cholesterol into lipoproteins J. Lipid Res., November 1, 2006; 47(11): 2575 - 2580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. O'Sullivan, Y. C. O'Callaghan, and N. M. O'Brien Differential Effects of Mixtures of Cholesterol Oxidation Products on Bovine Aortic Endothelial Cells and Human Monocytic U937 Cells International Journal of Toxicology, May 1, 2005; 24(3): 173 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Mayne, B. Cartmel, H. Lin, T. Zheng, and W. J. Goodwin Jr Low Plasma Lycopene Concentration is Associated with Increased Mortality in a Cohort of Patients with Prior Oral, Pharynx or Larynx Cancers J. Am. Coll. Nutr., February 1, 2004; 23(1): 34 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Staprans, X.-M. Pan, J. H. Rapp, and K. R. Feingold Oxidized cholesterol in the diet is a source of oxidized lipoproteins in human serum J. Lipid Res., April 1, 2003; 44(4): 705 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ringseis and K. Eder Insufficient Dietary Vitamin E Increases the Concentration of 7{beta}-Hydroxycholesterol in Tissues of Rats Fed Salmon Oil J. Nutr., December 1, 2002; 132(12): 3732 - 3735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Adachi, R. Kudo, Y. Ueno, R. Hunter, R. Rajendram, E. Want, and V. R. Preedy Heart 7-Hydroperoxycholesterol and Oxysterols Are Elevated in Chronically Ethanol-Fed Rats J. Nutr., November 1, 2001; 131(11): 2916 - 2920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Iuliano, F. Micheletta, M. Maranghi, G. Frati, U. Diczfalusy, and F. Violi Bioavailability of Vitamin E as Function of Food Intake in Healthy Subjects: Effects on Plasma Peroxide-Scavenging Activity and Cholesterol-Oxidation Products Arterioscler. Thromb. Vasc. Biol., October 1, 2001; 21 (10): e34 - e37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Li, H. Dalen, J. W. Eaton, and X.-M. Yuan Apoptotic Death of Inflammatory Cells in Human Atheroma Arterioscler. Thromb. Vasc. Biol., July 1, 2001; 21(7): 1124 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Spyridopoulos, J. Wischhusen, B. Rabenstein, P. Mayer, D. I. Axel, K.-U. Frohlich, and K. R. Karsch Alcohol Enhances Oxysterol-Induced Apoptosis in Human Endothelial Cells by a Calcium-Dependent Mechanism Arterioscler. Thromb. Vasc. Biol., March 1, 2001; 21(3): 439 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Porkkala-Sarataho, J. T. Salonen, K. Nyyssonen, J. Kaikkonen, R. Salonen, U. Ristonmaa, U. Diczfalusy, R. Brigelius-Flohe, S. Loft, and H. E. Poulsen Long-Term Effects of Vitamin E, Vitamin C, and Combined Supplementation on Urinary 7-Hydro-8-Oxo-2'-Deoxyguanosine, Serum Cholesterol Oxidation Products, and Oxidation Resistance of Lipids in Nondepleted Men Arterioscler. Thromb. Vasc. Biol., September 1, 2000; 20(9): 2087 - 2093. [Abstract] [Full Text] [PDF]
|
|