© 1999 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Correlation Between Flow-Mediated Vasodilatation of the Brachial Artery and Intima-Media Thickness in the Carotid Artery in Men
From the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Correspondence to Yasuyoshi Ouchi, MD, PhD, Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail youchi-tky{at}umin.u-tokyo.ac.jp
Abstract—Endothelial
dysfunction has been reported to be the initial step in
atherosclerosis. A noninvasive technique that uses
ultrasound to measure the intima-media thickness of the carotid artery
has been applied to evaluate localized atherosclerosis.
This study was undertaken to elucidate whether
endothelial dysfunction in the brachial artery is
related to the intima-media thickness of the carotid artery.
Thirty-four men with atherosclerosis (mean±SE
age 61±2 years) and 33 age-matched men without clinical
atherosclerosis were examined. The intima-media
thickness and plaque formation of the common carotid artery were
assessed by B-mode ultrasonography. We also noninvasively measured
brachial artery diameter by the same ultrasound machine when the
subjects were at rest, during reactive hyperemia, which causes
endothelium-dependent vasodilatation, and after
sublingual administration of nitroglycerin, which
causes endothelium-independent vasodilatation. The
atherosclerosis group had a significantly greater
intima-media thickness of the common carotid artery than did the
control group (1.02±0.04 versus 0.91±0.03 mm,
P<0.05). The flow-mediated diameter (FMD) increase
(percent FMD=
D/Dx100) in the atherosclerosis group
was significantly smaller than that in the control group (2.8±0.4%
versus 5.1±0.6%, P<0.01). A significant negative
correlation between the intima-media thickness of the carotid artery
and percent FMD was found in all of the subjects. On multiple
regression analysis, percent FMD showed a significant negative
correlation with the intima-media thickness of the common carotid
artery. These findings support the concept that
endothelial dysfunction is significantly related
to atherogenesis.
Key Words: vasodilatation • endothelium • carotid artery • atherosclerosis
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