Arteriosclerosis, Thrombosis, and Vascular Biology. 1999;19:2448-2455
© 1999 American Heart Association, Inc.
Atherosclerosis and Lipoproteins |
Gender Difference in Postprandial Lipemia
Importance of Visceral Adipose Tissue Accumulation
Abstract—Insulin resistance, hyperinsulinemia, hypertriglyceridemia, and low HDL-cholesterol concentrations are common features of a plurimetabolic syndrome, which increases the risk of coronary artery disease. Although it has been proposed that the development of atherosclerosis through alterations in plasma lipid levels could be a postprandial phenomenon, most studies on gender differences in plasma lipoprotein-lipid concentrations have reported fasting levels. Therefore, the aim of our study was to examine the response of postprandial triglyceride-rich lipoproteins to a standardized meal in 63 men and 25 women. In addition to the measurement of fasting and postprandial plasma lipid levels, numerous physical and metabolic variables were assessed, including body composition by underwater weighing and body fat distribution by computed tomography. Although no gender difference was noted in total body fat mass, men were characterized by a preferential accumulation of abdominal adipose tissue as revealed by an increased waist circumference and a greater visceral adipose tissue accumulation (50% difference) compared with women (P<0.001). Men also showed a greater plasma triglyceride response (P<0.005) as well as increased postprandial insulin and free fatty acid levels compared with women (P<0.01). Visceral adipose tissue was significantly associated with the postprandial triglyceride response in both genders (men: r=0.49, P<0.0001; women: r=0.43, P<0.05). Finally, when men and women were matched for visceral adipose tissue accumulation, the gender difference in postprandial plasma triglyceride response was eliminated. Thus results of the present study suggest that the well known gender difference in visceral adipose tissue accumulation is an important contributing factor involved in the exaggerated postprandial triglyceride-rich lipoprotein response noted in men compared with women.
Key Words: postprandial lipemia • gender differences • visceral obesity • free fatty acids
This article has been cited by other articles:
 |
|
 |
|
  G. D. Kolovou and H. G. Bilianou Influence of Aging and Menopause on Lipids and Lipoproteins in Women Angiology, August 1, 2008; 59(2_suppl): 54S - 57S. [Abstract] [PDF]
|
|
|
|
 |
|
 J.-P. Despres, I. Lemieux, J. Bergeron, P. Pibarot, P. Mathieu, E. Larose, J. Rodes-Cabau, O. F. Bertrand, and P. Poirier Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk Arterioscler. Thromb. Vasc. Biol., June 1, 2008; 28(6): 1039 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D. Knuth and J. F. Horowitz The Elevation of Ingested Lipids within Plasma Chylomicrons Is Prolonged in Men Compared with Women J. Nutr., June 1, 2006; 136(6): 1498 - 1503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Mittendorfer Sexual Dimorphism in Human Lipid Metabolism J. Nutr., April 1, 2005; 135(4): 681 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Elosua, J. M. Ordovas, L. A. Cupples, C. S. Fox, J. F. Polak, P. A. Wolf, R. A. D'Agostino Sr., and C. J. O'Donnell Association of APOE genotype with carotid atherosclerosis in men and women: the Framingham Heart Study J. Lipid Res., October 1, 2004; 45(10): 1868 - 1875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Cianflone, R. Zakarian, C. Couillard, B. Delplanque, J.-P. Despres, and A. Sniderman Fasting acylation-stimulating protein is predictive of postprandial triglyceride clearance J. Lipid Res., January 1, 2004; 45(1): 124 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.J.M. Halkes, H. van Dijk, C. Verseyden, P.P.Th. de Jaegere, H.W.M Plokker, S. Meijssen, D.W. Erkelens, and M. C. Cabezas Gender Differences in Postprandial Ketone Bodies in Normolipidemic Subjects and in Untreated Patients With Familial Combined Hyperlipidemia Arterioscler. Thromb. Vasc. Biol., October 1, 2003; 23(10): 1875 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. C. Wascher, B. Paulweber, L. Malaimare, A. Stadlmayr, B. Iglseder, I. Schmoelzer, and W. Renner Associations of a Human G Protein {beta}3 Subunit Dimorphism With Insulin Resistance and Carotid Atherosclerosis Stroke, March 1, 2003; 34(3): 605 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Shah, A. Vella, A. Basu, R. Basu, A. Adkins, W. F. Schwenk, C. M. Johnson, K. S. Nair, M. D. Jensen, and R. A. Rizza Elevated Free Fatty Acids Impair Glucose Metabolism in Women: Decreased Stimulation of Muscle Glucose Uptake and Suppression of Splanchnic Glucose Production During Combined Hyperinsulinemia and Hyperglycemia Diabetes, January 1, 2003; 52(1): 38 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Horton, S. R. Commerford, M. J. Pagliassotti, and D. H. Bessesen Postprandial leg uptake of triglyceride is greater in women than in men Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1192 - E1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Mattes Oral Fat Exposure Increases the First Phase Triacylglycerol Concentration Due to Release of Stored Lipid in Humans J. Nutr., December 1, 2002; 132(12): 3656 - 3662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Couillard, N. Bergeron, A. Pascot, N. Almeras, J. Bergeron, A. Tremblay, D. Prud'homme, and J.-P. Despres Evidence for impaired lipolysis in abdominally obese men: postprandial study of apolipoprotein B-48- and B-100-containing lipoproteins Am. J. Clinical Nutrition, August 1, 2002; 76(2): 311 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E Roeters van Lennep, H.T. Westerveld, D.W. Erkelens, and E. E van der Wall Risk factors for coronary heart disease: implications of gender Cardiovasc Res, February 15, 2002; 53(3): 538 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Perseghin, P. Scifo, E. Pagliato, A. Battezzati, S. Benedini, L. Soldini, G. Testolin, A. Del Maschio, and L. Luzi Gender Factors Affect Fatty Acids-Induced Insulin Resistance in Nonobese Humans: Effects of Oral Steroidal Contraception J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3188 - 3196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Barnekow-Bergkvist, G. Hedberg, U. Janlert, and E. Jansson Adolescent determinants of cardiovascular risk factors in adult men and women Scand J Public Health, July 1, 2001; 29(3): 208 - 217. [Abstract] [PDF]
|
|
|
|
|
|
J. P. Frias, G. B. Macaraeg, J. Ofrecio, J. G. Yu, J. M. Olefsky, and Y. T. Kruszynska Decreased Susceptibility to Fatty Acid-Induced Peripheral Tissue Insulin Resistance in Women Diabetes, June 1, 2001; 50(6): 1344 - 1350. [Abstract] [Full Text]
|
|
|
|
|
|
J. M. Bard, M. A. Charles, I. Juhan-Vague, P. Vague, P. Andre, M. Safar, J. C. Fruchart, E. Eschwege, and o. b. o. t. BIGPRO Study Group Accumulation of Triglyceride-Rich Lipoprotein in Subjects With Abdominal Obesity : The Biguanides and the Prevention of the Risk of Obesity (BIGPRO) 1 Study Arterioscler. Thromb. Vasc. Biol., March 1, 2001; 21(3): 407 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Couillard, N. Bergeron, J. Bergeron, A. Pascot, P. Mauriège, A. Tremblay, D. Prud’homme, C. Bouchard, and J.-P. Després Metabolic Heterogeneity Underlying Postprandial Lipemia among Men with Low Fasting High Density Lipoprotein Cholesterol Concentrations J. Clin. Endocrinol. Metab., December 1, 2000; 85(12): 4575 - 4582. [Abstract] [Full Text]
|
|