This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Calleja, L. Articles by Osada, J. Search for Related Content PubMed PubMed Citation Articles by Calleja, L. Articles by Osada, J. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Compound via MeSH Substance via MeSH Hazardous Substances DB COCONUT OIL OLIVE OIL PALM OIL (FROM FRUIT) VEGETABLE OIL Medline Plus Health Information Dietary Fats Diets Related Collections Nutrition Animal models of human disease Pathophysiology Risk Factors Genetically altered mice Lipid and lipoprotein metabolism

(Arteriosclerosis, Thrombosis, and Vascular Biology. 1999;19:2368-2375.)
© 1999 American Heart Association, Inc.

Atherosclerosis and Lipoproteins

Low-Cholesterol and High-Fat Diets Reduce Atherosclerotic Lesion Development in ApoE-Knockout Mice

Lucía Calleja; Miguel A. París; Antoni Paul; Elisabet Vilella; Jorge Joven; Antonio Jiménez; Gabriel Beltrán; Marino Uceda; Nobuyo Maeda; Jesús Osada
Abstract—We have investigated the effect of most common oils used in human nutrition on the development of atherosclerosis in apoE-knockout mice. Seven groups of animals, separated according to sex, were fed for 10 weeks either chow diet or the chow diet 10% (wt/wt) enriched with different oils (palm, coconut, 2 types of olive oil, and 2 types of sunflower oil) without addition of cholesterol. At the end of this period, plasma lipid parameters were measured and vascular lesions scored. None of the diets induced changes in plasma cholesterol concentrations, whereas plasma triglycerides were uniformly reduced in all diet groups. Some diets caused significant reductions in the size of atherosclerotic lesions in males and others in females; males responded most to sunflower oils and females to palm oil and one olive oil (II). The lesion reduction in males consuming sunflower oils was associated with the decrease of triglycerides in triglyceride-rich lipoproteins, whereas the decrease in females consuming olive oil II or palm oil was accompanied by an increase in plasma apoA-I. The increase in plasma apoA-I in the latter condition, is mainly due to overexpression of hepatic message elicited by a mechanism independent of apoE ligand. The data suggest that the different diets modulate lesion development in a gender specific manner and by different mechanisms and that the development of atherosclerosis, due to genetic deficiencies, may be modulated by nutritional maneuvers that may be implemented in human nutrition.

Key Words: cholesterol • apolipoprotein • atherosclerosis • dietary fat

This article has been cited by other articles:

				N. Guillen, M. A. Navarro, C. Arnal, E. Noone, J. M. Arbones-Mainar, S. Acin, J. C. Surra, P. Muniesa, H. M. Roche, and J. Osada Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver Physiol Genomics, May 13, 2009; 37(3): 187 - 198. [Abstract] [Full Text] [PDF]

				A. Paul, B. H.-J. Chang, L. Li, V. K. Yechoor, and L. Chan Deficiency of Adipose Differentiation-Related Protein Impairs Foam Cell Formation and Protects Against Atherosclerosis Circ. Res., June 20, 2008; 102(12): 1492 - 1501. [Abstract] [Full Text] [PDF]

				D.-Z. Hsu, S.-P. Chien, Y.-H. Li, and M.-Y. Liu Sesame Oil Does Not Show Accumulatively Enhanced Protection Against Oxidative Stress-Associated Hepatic Injury in Septic Rats JPEN J Parenter Enteral Nutr, May 1, 2008; 32(3): 276 - 280. [Abstract] [Full Text] [PDF]

				J. Garcia-Herrera, M. C. Marca, E. Brot-Laroche, N. Guillen, S. Acin, M. A. Navarro, J. Osada, and M. J. Rodriguez-Yoldi Protein kinases, TNF-{alpha}, and proteasome contribute in the inhibition of fructose intestinal transport by sepsis in vivo Am J Physiol Gastrointest Liver Physiol, January 1, 2008; 294(1): G155 - G164. [Abstract] [Full Text] [PDF]

				M. A. Guzman, M. A. Navarro, R. Carnicer, A. J. Sarria, S. Acin, C. Arnal, P. Muniesa, J. C. Surra, J. M. Arbones-Mainar, N. Maeda, et al. Cystathionine {beta}-synthase is essential for female reproductive function Hum. Mol. Genet., November 1, 2006; 15(21): 3168 - 3176. [Abstract] [Full Text] [PDF]

				S. Acin, M. A. Navarro, J. M. Arbones-Mainar, N. Guillen, A. J. Sarria, R. Carnicer, J. C. Surra, I. Orman, J. C. Segovia, R. d. l. Torre, et al. Hydroxytyrosol Administration Enhances Atherosclerotic Lesion Development in Apo E Deficient Mice J. Biochem., September 1, 2006; 140(3): 383 - 391. [Abstract] [Full Text] [PDF]

				J. M. Arbones-Mainar, M. A. Navarro, S. Acin, M. A. Guzman, C. Arnal, J. C. Surra, R. Carnicer, H. M. Roche, and J. Osada Trans-10, cis-12- and cis-9, trans-11-Conjugated Linoleic Acid Isomers Selectively Modify HDL-Apolipoprotein Composition in Apolipoprotein E Knockout Mice J. Nutr., February 1, 2006; 136(2): 353 - 359. [Abstract] [Full Text] [PDF]

				Z. Yang, C. A. Knight, M. M. Mamerow, K. Vickers, A. Penn, E. M. Postlethwait, and S. W. Ballinger Prenatal Environmental Tobacco Smoke Exposure Promotes Adult Atherogenesis and Mitochondrial Damage in Apolipoprotein E-/- Mice Fed a Chow Diet Circulation, December 14, 2004; 110(24): 3715 - 3720. [Abstract] [Full Text] [PDF]

				K. S. Meir and E. Leitersdorf Atherosclerosis in the Apolipoprotein E-Deficient Mouse: A Decade of Progress Arterioscler Thromb Vasc Biol, June 1, 2004; 24(6): 1006 - 1014. [Abstract] [Full Text] [PDF]

				A. Paul, K. W.S. Ko, L. Li, V. Yechoor, M. A. McCrory, A. J. Szalai, and L. Chan C-Reactive Protein Accelerates the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice Circulation, February 10, 2004; 109(5): 647 - 655. [Abstract] [Full Text] [PDF]

				A. M. Troen, E. Lutgens, D. E. Smith, I. H. Rosenberg, and J. Selhub The atherogenic effect of excess methionine intake PNAS, December 9, 2003; 100(25): 15089 - 15094. [Abstract] [Full Text] [PDF]

				G. Schonfeld Familial hypobetalipoproteinemia: a review J. Lipid Res., May 1, 2003; 44(5): 878 - 883. [Abstract] [Full Text] [PDF]

				M. Merkel, W. Velez-Carrasco, L. C. Hudgins, and J. L. Breslow Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice PNAS, October 16, 2001; (2001) 231490498. [Abstract] [Full Text] [PDF]

				Y.-Y. Fan, K. S. Ramos, and R. S. Chapkin Dietary {{gamma}}-Linolenic Acid Suppresses Aortic Smooth Muscle Cell Proliferation and Modifies Atherosclerotic Lesions in Apolipoprotein E Knockout Mice J. Nutr., June 1, 2001; 131(6): 1675 - 1681. [Abstract] [Full Text]

				M. Merkel, W. Velez-Carrasco, L. C. Hudgins, and J. L. Breslow Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice PNAS, November 6, 2001; 98(23): 13294 - 13299. [Abstract] [Full Text] [PDF]