Physical Activity Status and Adverse Age-Related Differences in Coagulation and Fibrinolytic Factors in Women

From the Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology, University of Colorado, Boulder (C.A.D., P.P.I., D.R.S.); and the Department of Medicine, Divisions of Cardiology and Geriatric Medicine, University of Colorado, Health Sciences Center, Denver (D.R.S.).

Correspondence to Christopher DeSouza, PhD, Department of Kinesiology, University of Colorado, Campus Box 354, Boulder, CO 80309. E-mail desouzac{at}stripe.Colorado.edu

Abstract—Adverse changes in coagulation and fibrinolytic factors are thought to contribute to the increased risk of cardiovascular disease and atherothrombosis with age. We tested the hypothesis that such age-related changes in specific coagulation and fibrinolytic factors are absent in physically active women. Resting levels of plasma fibrinogen, tissue-type plasminogen activator (t-PA) antigen and activity, plasminogen activator inhibitor-1 (PAI-1) antigen and activity, and fibrin D-dimer were measured in 24 healthy premenopausal women: 11 sedentary (aged 28±1 years; Pre-S) and 13 physically active (aged 30±1 years; Pre-PA) and in 27 healthy postmenopausal women: 14 sedentary (aged 61±1 years; Post-S) and 13 physically active (aged 58±1 years; Post-PA). Post-S had higher (P<.05) fibrinogen, t-PA antigen, PAI-1 antigen, PAI-1 activity, and fibrin D-dimer levels and lower t-PA activity than Pre-S. Post-PA demonstrated lower (P<.01) plasma fibrinogen, t-PA antigen, PAI-1 antigen, and PAI-1 activity and higher (P<.01) t-PA activity levels than Post-S. In addition, plasma fibrin D-dimer levels tended (P=.06) to be lower in Post-PA than in Post-S. Although plasma levels of fibrinogen and fibrin D-dimer in Post-PA were lower than in Post-S, they were higher (P<.05) than in Pre-PA. Importantly, however, the fibrinolytic profile of Post-PA did not differ from that of Pre-PA. The results of the present study demonstrate that the adverse age-associated differences in plasma fibrinogen concentrations and the endogenous fibrinolytic system in sedentary healthy women are either attenuated or absent in highly physically active women. The smaller or absent age-related differences in coagulation and fibrinolytic factors in women who habitually exercise may represent an important mechanism contributing to their lower age-related increase in both cardiovascular disease and atherothrombotic events. Future studies need to determine whether women who are moderately active would demonstrate the same favorable hemostatic profile.

Key Words: aging • exercise • fibrinogen • fibrinolytic system • fibrin D-dimer

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