© 1998 American Heart Association, Inc.
Original Contributions |
Plasma Extracellular Superoxide Dismutase Levels in an Australian Population With Coronary Artery Disease
From the Department of Cardiovascular Medicine, University of New South Wales, Prince Henry/Prince of Wales Hospitals, Sydney, Australia (X.L.W., A.S.S., D.E.L.W.), and the Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu, Japan (T.A.).
Correspondence to Dr X.L. Wang, Department of Cardiovascular Medicine, Edmund Blacket Building, Ground Floor, Prince of Wales Hospital, Avoca St, Randwick, NSW 2031, Australia. E-mail x.l.wang{at}unsw.edu.au
Abstract—In vitro experiments
suggest that free radicals may contribute importantly to atherogenesis.
Superoxide dismutase (SOD), particularly extracellular SOD (EC-SOD),
which accounts for the majority of SOD biological activity, is a major
superoxide scavenger. We explored factors that may affect plasma EC-SOD
levels measured by ELISA and assessed the association between plasma
EC-SOD and coronary artery disease documented angiographically
in 590 white Australian patients 
65 years old. Mean±SEM plasma
EC-SOD in female patients (113.6±13.2 ng/mL) was significantly higher
than in male patients (86.6±5.1 ng/mL, P<0.0001), and
all 19 patients with levels >400 ng/mL were heterozygous for the
Arg213
Gly mutation at the EC-SOD gene; there was also a positive
correlation with age (r=0.131, P=0.0016).
Plasma EC-SOD in current smokers (75.0±9.3 ng/mL) was much lower than
in nonsmokers (111.7±8.2 ng/mL, P<0.01), and
ex-smokers had intermediate levels (84.3±7.1 ng/mL). Levels were
significantly lower in patients with than in those without a history of
acute myocardial infarction (MI) (76.1±7.5 versus 110.1±6.0 ng/mL,
P<0.05), and low plasma EC-SOD was independently
associated with an increased likelihood of a history of MI (OR, 2.04;
95% CI, 1.10 to 3.82); higher EC-SOD levels also tended to be
associated with delayed onset of MI. In conclusion, our study
establishes that in patients assessed by coronary angiography,
circulating EC-SOD is lower in men than in women and in smokers of each
sex and that low levels are independently associated with a history of
MI. These findings are consistent with EC-SOD's being
protective and contributing to reduced coronary risk.
Key Words: extracellular superoxide dismutase • extracellular superoxide dismutase Arg213Gly mutation • coronary disease • smoking • myocardial infarction
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