This Article Full Text Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lopez-Miranda, J. Articles by Perez-Jimenez, F. Search for Related Content PubMed PubMed Citation Articles by Lopez-Miranda, J. Articles by Perez-Jimenez, F.

(Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:1765-1773.)
© 1997 American Heart Association, Inc.

Articles

Dietary Fat Clearance in Normal Subjects Is Modulated by Genetic Variation at the Apolipoprotein B Gene Locus

J. Lopez-Miranda; J.M. Ordovas; M.A. Ostos; C. Marin; S. Jansen; J. Salas; A. Blanco-Molina; J.A. Jimenez-Pereperez; F. Lopez-Segura; ; F. Perez-Jimenez

From the Unidad de Lipidos y Arteriosclerosis, Hospital Universitario Reina Sofia, Cordoba, Spain (J.L.-M., M.A.O., C.M., S.J., J.S., A.B.-M., J.A.J.-P., F.L.-S., F.P.-J.), and the Lipid Metabolism Laboratory, USDA Human Nutrition Research Center on Aging, Tufts University, Boston (J.M.O.).

Correspondence and reprint request to Prof. Francisco Perez Jimenez, Unidad de Lipidos y Arteriosclerosis, Hospital Universitario Reina Sofia, Avda. Menendez Pidal, s/n. 14004 Cordoba, Spain.

Abstract Apolipoprotein B (apo B) plays a dominant role in cholesterol homeostasis. Several polymorphic sites within or adjacent to the gene locus for apo B have been detected. The X+ allele (XbaI restriction site present) of the XbaI restriction fragment polymorphism on the apo B gene has been found in some studies to be associated with higher serum cholesterol and/or triglyceride levels and with greater dietary response. The present study was designed to evaluate whether the apo B XbaI polymorphism was associated with the interindividual variability observed during postprandial lipemia. Fifty-one healthy young male volunteers [20 X-/X- (X-), and 31 X+/X- or X+/X+ (X+)], homozygotes for the apo E3 allele, were subjected to a vitamin A-fat load test. Subjects with the X- genotype had significantly greater retinyl palmitate (RP) and apo B-48 postprandial responses on both the large and the small TRL lipoprotein fractions compared with X+ subjects. In summary, subjects with the X-/X- genotype at the apo B locus have a greater postprandial response than X+ subjects. These differences observed in postprandial lipoprotein metabolism could explain some of the reported associations of this polymorphism to coronary heart disease risk.

Key Words: postprandial lipemia • apolipoprotein B • XbaI polymorphism • triglycerides • retinyl palmitate

This article has been cited by other articles:

				G. Andreotti, J. Chen, Y.-T. Gao, A. Rashid, B. E. Chen, P. Rosenberg, L. C. Sakoda, J. Deng, M.-C. Shen, B.-S. Wang, et al. Polymorphisms of Genes in the Lipid Metabolism Pathway and Risk of Biliary Tract Cancers and Stones: A Population-Based Case-Control Study in Shanghai, China Cancer Epidemiol. Biomarkers Prev., March 1, 2008; 17(3): 525 - 534. [Abstract] [Full Text] [PDF]

				J. Delgado-Lista, F. Perez-Jimenez, T. Tanaka, P. Perez-Martinez, Y. Jimenez-Gomez, C. Marin, J. Ruano, L. Parnell, J. M. Ordovas, and J. Lopez-Miranda An Apolipoprotein A-II Polymorphism (-265T/C, rs5082) Regulates Postprandial Response to a Saturated Fat Overload in Healthy Men J. Nutr., September 1, 2007; 137(9): 2024 - 2028. [Abstract] [Full Text] [PDF]

				C. Marin, J. Lopez-Miranda, P. Gomez, E. Paz, P. Perez-Martinez, F. Fuentes, J. A. Jimenez-Pereperez, J. M. Ordovas, and F. Perez-Jimenez Effects of the human apolipoprotein A-I promoter G-A mutation on postprandial lipoprotein metabolism Am. J. Clinical Nutrition, August 1, 2002; 76(2): 319 - 325. [Abstract] [Full Text] [PDF]

				B. Lundahl, A. Hamsten, and F. Karpe Postprandial Plasma ApoB-48 Levels Are Influenced by a Polymorphism in the Promoter of the Microsomal Triglyceride Transfer Protein Gene Arterioscler Thromb Vasc Biol, February 1, 2002; 22(2): 289 - 293. [Abstract] [Full Text] [PDF]

				K. J. Hockey, R. A. Anderson, V. R. Cook, R. R. Hantgan, and R. B. Weinberg Effect of the apolipoprotein A-IV Q360H polymorphism on postprandial plasma triglyceride clearance J. Lipid Res., February 1, 2001; 42(2): 211 - 217. [Abstract] [Full Text]

				S. Q. Ye and P. O Kwiterovich Jr Influence of genetic polymorphisms on responsiveness to dietary fat and cholesterol Am. J. Clinical Nutrition, November 1, 2000; 72 (5): 1275S - 1284S. [Abstract] [Full Text] [PDF]

				M. Rantala, T. T Rantala, M. J Savolainen, Y. Friedlander, and Y A. Kesaniemi Apolipoprotein B gene polymorphisms and serum lipids: meta-analysis of the role of genetic variation in responsiveness to diet Am. J. Clinical Nutrition, March 1, 2000; 71(3): 713 - 724. [Abstract] [Full Text] [PDF]

				M. A. Ostos, J. Lopez-Miranda, J. M. Ordovas, C. Marin, A. Blanco, P. Castro, F. Lopez-Segura, J. Jimenez-Pereperez, and F. Perez-Jimenez Dietary fat clearance is modulated by genetic variation in apolipoprotein A-IV gene locus J. Lipid Res., December 1, 1998; 39(12): 2493 - 2500. [Abstract] [Full Text]

				M. Orth, M. Hanisch, G. Kroning, M. Porsch-Ozcurumez, H. Wieland, and C. Luley Fluorometric determination of total retinyl esters in triglyceride-rich lipoproteins Clin. Chem., July 1, 1998; 44(7): 1459 - 1465. [Abstract] [Full Text] [PDF]