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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:1765-1773.)
© 1997 American Heart Association, Inc.

Articles

Dietary Fat Clearance in Normal Subjects Is Modulated by Genetic Variation at the Apolipoprotein B Gene Locus

J. Lopez-Miranda; J.M. Ordovas; M.A. Ostos; C. Marin; S. Jansen; J. Salas; A. Blanco-Molina; J.A. Jimenez-Pereperez; F. Lopez-Segura; ; F. Perez-Jimenez

From the Unidad de Lipidos y Arteriosclerosis, Hospital Universitario Reina Sofia, Cordoba, Spain (J.L.-M., M.A.O., C.M., S.J., J.S., A.B.-M., J.A.J.-P., F.L.-S., F.P.-J.), and the Lipid Metabolism Laboratory, USDA Human Nutrition Research Center on Aging, Tufts University, Boston (J.M.O.).

Correspondence and reprint request to Prof. Francisco Perez Jimenez, Unidad de Lipidos y Arteriosclerosis, Hospital Universitario Reina Sofia, Avda. Menendez Pidal, s/n. 14004 Cordoba, Spain.

Abstract Apolipoprotein B (apo B) plays a dominant role in cholesterol homeostasis. Several polymorphic sites within or adjacent to the gene locus for apo B have been detected. The X+ allele (XbaI restriction site present) of the XbaI restriction fragment polymorphism on the apo B gene has been found in some studies to be associated with higher serum cholesterol and/or triglyceride levels and with greater dietary response. The present study was designed to evaluate whether the apo B XbaI polymorphism was associated with the interindividual variability observed during postprandial lipemia. Fifty-one healthy young male volunteers [20 X-/X- (X-), and 31 X+/X- or X+/X+ (X+)], homozygotes for the apo E3 allele, were subjected to a vitamin A-fat load test. Subjects with the X- genotype had significantly greater retinyl palmitate (RP) and apo B-48 postprandial responses on both the large and the small TRL lipoprotein fractions compared with X+ subjects. In summary, subjects with the X-/X- genotype at the apo B locus have a greater postprandial response than X+ subjects. These differences observed in postprandial lipoprotein metabolism could explain some of the reported associations of this polymorphism to coronary heart disease risk.

Key Words: postprandial lipemia • apolipoprotein B • XbaI polymorphism • triglycerides • retinyl palmitate

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