© 1997 American Heart Association, Inc.
Articles |
Coagulation Factor VII and the Risk of Coronary Heart Disease in Healthy Men
From the Institut für Klinische Chemie und Laboratoriumsmedizin, Westfälische Wilhelms-Universität Münster, Münster (R.J., G.A.); the Städtisches Klinikum Solingen, Solingen (J.H.); the Institut für Arterioskleroseforschung an der Westfälischen Wilhelms-Universität Münster, Münster (H.S., G.A.); and Medizinische Klinik A, Westfälische Wilhelms-Universität Münster, Münster (J. van de L.), Germany.
Correspondence to Dr med Ralf Junker, Institut für Klinische Chemie und Laboratoriumsmedizin, Westfälische Wilhelms-Universität Münster, Albert Schweitzer-Straße 33, 48129 Münster, Germany. E-mail junkerr{at}uni-muenster.de
Abstract Numerous investigations have demonstrated the role of thrombus formation in the pathogenesis of coronary heart disease (CHD). A tendency to thrombosis may also be indicated by elevated levels of coagulation factor VII clotting activity (FVIIc). Significant associations of FVIIc with increased coronary risk, however, have been found only in the Northwick Park Heart Study. Here we present the results of the 8-year follow-up of FVIIc measurements in 2780 healthy men of the Prospective Cardiovascular Münster study. In the study population (age at entry, 49.3±6.1 years, mean±SD), 130 CHD events occurred during follow-up. FVIIc was significantly higher in subjects with coronary events than in those without (112.4±20.1% vs 108.7±21.4%, P=.023). Compared with individuals without coronary events, FVIIc was not significantly higher in men with nonfatal events (111.7±20.4%; P=.196, n=93), but there was a tendency toward higher FVIIc activity in subjects with fatal events (114.6±19.5%; P=.076, n=37). In the multiple logistic regression analysis, we did not find FVIIc to be an independent risk factor for CHD, and the significance of FVIIc disappeared after total cholesterol, LDL-cholesterol, and triglycerides were taken into account. The increase in the number of CHD events through higher levels of FVIIc was more pronounced in the presence of additional cardiovascular risk factors: smoking; myocardial infarction events in family; angina pectoris; high levels of fibrinogen, total cholesterol, LDL cholesterol, and triglycerides; and a low level of HDL cholesterol. We conclude that FVIIc is a risk factor for CHD, especially in the presence of additional risk factors, and must be taken into account when assessing cardiovascular risk in men.
Key Words: prospective study • myocardial infarction • coronary risk factors
This article has been cited by other articles:
 |
|
 |
|
  S.-Y. Chuang, C.-H. Bai, W.-H. Chen, L.-M. Lien, and W.-H. Pan Fibrinogen Independently Predicts the Development of Ischemic Stroke in a Taiwanese Population: CVDFACTS Study Stroke, May 1, 2009; 40(5): 1578 - 1584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Wirtz, L. S. Redwine, C. Baertschi, M. Spillmann, U. Ehlert, and R. von Kanel Coagulation Activity Before and After Acute Psychosocial Stress Increases With Age Psychosom Med, May 1, 2008; 70(4): 476 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Sanders, F. Lewis, S. Slaughter, B. A Griffin, M. Griffin, I. Davies, D J. Millward, J. A Cooper, and G. J Miller Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of {alpha}-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP Study. Am. J. Clinical Nutrition, September 1, 2006; 84(3): 513 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Feinbloom and K. A. Bauer Assessment of Hemostatic Risk Factors in Predicting Arterial Thrombotic Events Arterioscler Thromb Vasc Biol, October 1, 2005; 25(10): 2043 - 2053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yamamoto, K. Takeshita, T. Kojima, J. Takamatsu, and H. Saito Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly Cardiovasc Res, May 1, 2005; 66(2): 276 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D.O. Lowe, A. Rumley, A. D. McMahon, I. Ford, D. St. J. O'Reilly, C. J. Packard, and for the West of Scotland Coronary Prevention Study Interleukin-6, Fibrin D-Dimer, and Coagulation Factors VII and XIIa in Prediction of Coronary Heart Disease Arterioscler Thromb Vasc Biol, August 1, 2004; 24(8): 1529 - 1534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tholstrup, G. J Miller, A. Bysted, and B. Sandstrom Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1125 - 1132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Kittel, F. Leynen, M. Stam, M. Dramaix, P. de Smet, R. Mak, G. De Backer, and M. Kornitzer Job conditions and fibrinogen in 14226 Belgian workers. The Belstress study Eur. Heart J., December 1, 2002; 23(23): 1841 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.M. Bladbjerg, S.O. Skouby, L.F. Andersen, and J. Jespersen Effects of different progestin regimens in hormone replacement therapy on blood coagulation factor VII and tissue factor pathway inhibitor Hum. Reprod., December 1, 2002; 17(12): 3235 - 3241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Stangl, G. Baumann, and K. Stangl Coronary atherogenic risk factors in women Eur. Heart J., November 2, 2002; 23(22): 1738 - 1752. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Marques-Vidal, E. Mazoyer, V. Bongard, P. Gourdy, J.-B. Ruidavets, L. Drouet, and J. Ferrieres Prevalence of Insulin Resistance Syndrome in Southwestern France and Its Relationship With Inflammatory and Hemostatic Markers Diabetes Care, August 1, 2002; 25(8): 1371 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Braunstein, D. W. Kershner, P. Bray, G. Gerstenblith, S. P. Schulman, W. S. Post, and R. S. Blumenthal Interaction of Hemostatic Genetics With Hormone Therapy : New Insights To Explain Arterial Thrombosis in Postmenopausal Women Chest, March 1, 2002; 121(3): 906 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Olsen, E. M. Bladbjerg, A. K. Hansen, and P. Marckmann A High Fat Meal Activates Blood Coagulation Factor VII in Rats J. Nutr., March 1, 2002; 132(3): 347 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Salomaa, V. Rasi, S. Kulathinal, E. Vahtera, M. Jauhiainen, C. Ehnholm, and J. Pekkanen Hemostatic Factors as Predictors of Coronary Events and Total Mortality: The FINRISK '92 Hemostasis Study Arterioscler Thromb Vasc Biol, February 1, 2002; 22(2): 353 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Williams and P. F. Bray Genetics of Arterial Prothrombotic Risk States Experimental Biology and Medicine, May 1, 2001; 226(5): 409 - 419. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. A. Cooper, G. J. Miller, K. A. Bauer, J. H. Morrissey, T. W. Meade, D. J. Howarth, S. Barzegar, J. P. Mitchell, and R. D. Rosenberg Comparison of Novel Hemostatic Factors and Conventional Risk Factors for Prediction of Coronary Heart Disease Circulation, December 5, 2000; 102(23): 2816 - 2822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Bladbjerg, A.-M. Munster, P. Marckmann, N. Keller, and J. Jespersen Dietary Factor VII Activation Does Not Increase Plasma Concentrations of Prothrombin Fragment 1+2 in Patients With Stable Angina Pectoris and Coronary Atherosclerosis Arterioscler Thromb Vasc Biol, November 1, 2000; 20(11): 2494 - 2499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pinotti, R. Toso, D. Girelli, D. Bindini, P. Ferraresi, M. L. Papa, R. Corrocher, G. Marchetti, and F. Bernardi Modulation of factor VII levels by intron 7 polymorphisms: population and in vitro studies Blood, June 1, 2000; 95(11): 3423 - 3428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Lane and P. J. Grant Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease Blood, March 1, 2000; 95(5): 1517 - 1532. [Full Text] [PDF]
|
|
|
|
|
|
L. F. Larsen, J. Jespersen, and P. Marckmann Are olive oil diets antithrombotic? Diets enriched with olive, rapeseed, or sunflower oil affect postprandial factor VII differently Am. J. Clinical Nutrition, December 1, 1999; 70(6): 976 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. I Mennen, M. P. de Maat, G. Meijer, P. Zock, D. E Grobbee, F. J Kok, C. Kluft, and E. G Schouten Postprandial response of activated factor VII in elderly women depends on the R353Q polymorphism Am. J. Clinical Nutrition, October 1, 1999; 70(4): 435 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Tracy, A. M. Arnold, W. Ettinger, L. Fried, E. Meilahn, and P. Savage The Relationship of Fibrinogen and Factors VII and VIII to Incident Cardiovascular Disease and Death in the Elderly : Results From the Cardiovascular Health Study Arterioscler Thromb Vasc Biol, July 1, 1999; 19(7): 1776 - 1783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. van 't Hooft, A. Silveira, P. Tornvall, A. Iliadou, E. Ehrenborg, P. Eriksson, and A. Hamsten Two Common Functional Polymorphisms in the Promoter Region of the Coagulation Factor VII Gene Determining Plasma Factor VII Activity and Mass Concentration Blood, May 15, 1999; 93(10): 3432 - 3441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Danesh, R. Collins, P. Appleby, and R. Peto Association of Fibrinogen, C-reactive Protein, Albumin, or Leukocyte Count With Coronary Heart Disease: Meta-analyses of Prospective Studies JAMA, May 13, 1998; 279(18): 1477 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. I. Mennen, M. P. M. de Maat, E. G. Schouten, C. Kluft, J. C. M. Witteman, A. Hofman, and D. E. Grobbee Dietary Effects on Coagulation Factor VII Vary across Genotypes of the R/Q353 Polymorphism in Elderly People J. Nutr., May 1, 1998; 128(5): 870 - 874. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. R. Stauffer, B. N. Chukwumezie, J. A. Wilberding, E. D. Rosen, and F. J. Castellino Characterization of Transcriptional Regulatory Elements in the Promoter Region of the Murine Blood Coagulation Factor VII Gene J. Biol. Chem., January 23, 1998; 273(4): 2277 - 2287. [Abstract] [Full Text] [PDF]
|
|