Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:1483-1489
© 1997 American Heart Association, Inc.
Articles |
Connective Tissue Growth Factor
Friend or Foe?
From the Cardiovascular Research Laboratory, Institute of Physiology, University of Zürich, and Cardiology, University Hospital Zürich, Switzerland.
Correspondence to Barry S. Oemar, MD, Cardiovascular Research Laboratory, Institute of Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. E-mail oemar{at}ubaclu.unibas.ch
Abstract Connective tissue growth factor (CTGF) is a novel cysteine-rich, secreted peptide, which is implicated in human atherosclerosis and fibrotic disorders such as systemic scleroderma. CTGF is a member of the peptide family that includes serum-induced immediate early gene products, a v-src–induced peptide, and a putative proto-oncogene. The CTGF gene family is a modular protein and is conserved throughout evolution. CTGF mRNA has been found in the human, mouse, chicken, frog, and fly. The functions of the CTGF gene family include embryogenesis, wound healing, and regulation of extracellular matrix production. Human CTGF is undetectable in normal blood vessels but overexpressed in atherosclerotic lesions, suggesting an important role in atherogenesis.
Key Words: atherosclerosis • development • fibrosis • gene expression • gene cloning
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|
|
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