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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:1163-1170.)
© 1997 American Heart Association, Inc.

Articles

Arterial Compliance in Obese Subjects Is Improved With Dietary Plant n-3 Fatty Acid From Flaxseed Oil Despite Increased LDL Oxidizability

Paul J. Nestel; Sylvia E. Pomeroy; Takayuki Sasahara; Takeshi Yamashita; Yu Lu Liang; Anthony M. Dart; Garry L. Jennings; Mavis Abbey; ; James D. Cameron

From the Baker Medical Research Institute (P.J.N., S.E.P., T.S., T.Y., A.M.D., G.L.J.) and Latrobe University (J.D.C.), Melbourne, and the CSIRO Division of Human Nutrition (M.A.), Adelaide, Australia.

Correspondence to Dr P.J. Nestel, Baker Medical Research Institute, Commercial Rd (PO Box 348), Prahran VIC 3181, Australia.

Abstract The compliance or elasticity of the arterial system, an important index of circulatory function, diminishes with increasing cardiovascular risk. Conversely, systemic arterial compliance improves through eating of fish and fish oil. We therefore tested the value of high intake of -linolenic acid, the plant precursor of fish fatty acids. Fifteen obese people with markers for insulin resistance ate in turn four diets of 4 weeks each: saturated/high fat (SHF), -linolenic acid/low fat (ALF), oleic/low fat (OLF), and SHF. Daily intake of -linolenic acid was 20 g from margarine products based on flax oil. Systemic arterial compliance was calculated from aortic flow velocity and aortic root driving pressure. Plasma lipids, glucose tolerance, and in vitro LDL oxidizability were also measured. Systemic arterial compliance during the first and last SHF periods was 0.42±0.12 (mean±SD) and 0.56±0.21 units based on milliliters per millimeter of mercury. It rose significantly to 0.78±0.28 (P<.0001) with ALF; systemic arterial compliance with OLF was 0.62±0.19, lower than with ALF (P<.05). Mean arterial pressures and results of oral glucose tolerance tests were similar during ALF, OLF, and second SHF; total cholesterol levels were also not significantly different. However, insulin sensitivity and HDL cholesterol diminished and LDL oxidizability increased with ALF. The marked rise in arterial compliance at least with -linolenic acid reflected rapid functional improvement in the systemic arterial circulation despite a rise in LDL oxidizability. Dietary n-3 fatty acids in flax oil thus confer a novel approach to improving arterial function.

Key Words: arterial compliance • flaxseed oil • obesity

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