© 1997 American Heart Association, Inc.
Articles |
Genetic Polymorphism of Paraoxonase and the Risk of Coronary Heart Disease
From the Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh (Pa).
Correspondence to M. Ilyas Kamboh, PhD, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St, Pittsburgh, PA 15261. E-mail ikamboh{at}helix.hgen.pitt.edu
Abstract Recent studies have implicated paraoxonase, an HDL-associated enzyme, in providing protection against LDL oxidation, thus affecting the risk of coronary heart disease (CHD) in the general population. In this study, we evaluated the distribution of a biallelic PON polymorphism at codon 192 (A and B alleles) and its relationship with plasma lipids and CHD in two racial groups comprising Asian Indians and Chinese from Singapore. The frequency of the B allele was significantly higher in Chinese control subjects than in Indian control subjects (0.58 versus 0.33; P<.0001). With the exception of a marginal effect on apolipoprotein A-I levels in Indians, no other significant association was observed between the PON polymorphism and quantitative lipid traits in either racial group. However, there was a race-specific association of the B allele with CHD in Indians but not in Chinese. The Indian CHD patients had a significantly higher frequency of the B allele than control subjects (.43 versus .33; P=.014). The age- and sex-adjusted odds ratio for developing CHD with the B allele (BB+AB genotypes) was 2.01 (95% CI, 1.17 to 3.45; P=.011) compared with the A allele (AA genotype). When the Indian patients were stratified into subgroups, the association remained significant in nondiabetic patients (odds ratio, 2.29; P=.008), and it became stronger in patients with myocardial infarction (odds ratio, 2.94; P=.004) than in patients without myocardial infarction (odds ratio, 1.11; P=.76). These data indicate that a common polymorphism in the PON gene is an independent risk factor for CHD in populations with white ancestry.
Key Words: genetic polymorphism • high-density lipoprotein • paraoxonase • Asian Indians • Chinese • coronary heart disease
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