This Article Full Text Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mörwald, S. Articles by Saito, Y. Search for Related Content PubMed PubMed Citation Articles by Mörwald, S. Articles by Saito, Y.

(Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:996-1002.)
© 1997 American Heart Association, Inc.

Articles

A Novel Mosaic Protein Containing LDL Receptor Elements Is Highly Conserved in Humans and Chickens

Sonja Mörwald; Hiroyuki Yamazaki; Hideaki Bujo; Jun Kusunoki; Tatsuro Kanaki; Kouichi Seimiya; Nobuhiro Morisaki; Johannes Nimpf; Wolfgang Johann Schneider; ; Yasushi Saito

From the Department of Molecular Genetics, Biocenter and University of Vienna, Austria (S.M., H.B., J.N., W.J.S.); the Second Department of Internal Medicine, Chiba University School of Medicine, Japan (H.Y., H.B., J.K., T.K., K.S., N.M., Y.S.); and the Department of Cell Biology, Kowa Research Institute, Kowa Co Ltd, Tsukuba, Japan (H.Y.).

Abstract Certain receptors belonging to the LDL receptor (LDLR) gene family appear to constitute a newly identified branch whose members are expressed in brain, in addition to other tissues. In support of this concept, we have now discovered the expression and delineated the molecular structures of a representative of this emerging branch from two such diverse species as human and chicken. This membrane receptor, called LR11 and thus far only known to exist in the rabbit, is a complex seven-domain mosaic protein containing, among other structural elements, a cluster of 11 LDLR ligand-binding repeats and a domain with homology to VPS10, a yeast receptor for vacuolar protein sorting. Cytoplasmic signature sequences define the receptor as competent for endocytosis. The most striking properties of LR11s are their (1) high degree of structural conservation (>80% identity among mammals and birds), with 100% identity in the membrane-spanning and cytoplasmic domains of rabbit and human; (2) lack of regulation by cholesterol and estrogen; and (3) expression in brain. The features of LR11 suggest important roles in intercellular and intracellular ligand transport processes, some of which it may share with other brain-specific LDLR family members.

Key Words: cell adhesion • brain • vacuolar protein sorting • gene family

This article has been cited by other articles:

				M. Rohe, A.-S. Carlo, H. Breyhan, A. Sporbert, D. Militz, V. Schmidt, C. Wozny, A. Harmeier, B. Erdmann, K. R. Bales, et al. Sortilin-related Receptor with A-type Repeats (SORLA) Affects the Amyloid Precursor Protein-dependent Stimulation of ERK Signaling and Adult Neurogenesis J. Biol. Chem., May 23, 2008; 283(21): 14826 - 14834. [Abstract] [Full Text] [PDF]

				T. Iwaki, A. Hosomi, S. Tokudomi, Y. Kusunoki, Y. Fujita, Y. Giga-Hama, N. Tanaka, and K. Takegawa Vacuolar protein sorting receptor in Schizosaccharomyces pombe. Microbiology, May 1, 2006; 152(Pt 5): 1523 - 1532. [Abstract] [Full Text] [PDF]

				Y. Zhu, H. Bujo, H. Yamazaki, K. Ohwaki, M. Jiang, S. Hirayama, T. Kanaki, M. Shibasaki, K. Takahashi, W. J. Schneider, et al. LR11, an LDL Receptor Gene Family Member, Is a Novel Regulator of Smooth Muscle Cell Migration Circ. Res., April 2, 2004; 94(6): 752 - 758. [Abstract] [Full Text] [PDF]

				K. Taira, H. Bujo, S. Hirayama, H. Yamazaki, T. Kanaki, K. Takahashi, I. Ishii, T. Miida, W. J. Schneider, and Y. Saito LR11, a Mosaic LDL Receptor Family Member, Mediates the Uptake of ApoE-Rich Lipoproteins In Vitro Arterioscler. Thromb. Vasc. Biol., September 1, 2001; 21(9): 1501 - 1506. [Abstract] [Full Text] [PDF]

				E. I. Posse de Chaves, D. E. Vance, R. B. Campenot, R. S. Kiss, and J. E. Vance Uptake of Lipoproteins for Axonal Growth of Sympathetic Neurons J. Biol. Chem., June 23, 2000; 275(26): 19883 - 19890. [Abstract] [Full Text] [PDF]

				W Hampe, I. Riedel, J Lintzel, C. Bader, I Franke, and H. Schaller Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator J. Cell Sci., January 12, 2000; 113(24): 4475 - 4485. [Abstract] [PDF]

				T. Kanaki, H. Bujo, S. Hirayama, I. Ishii, N. Morisaki, W. J. Schneider, and Y. Saito Expression of LR11, a Mosaic LDL Receptor Family Member, Is Markedly Increased in Atherosclerotic Lesions Arterioscler. Thromb. Vasc. Biol., November 1, 1999; 19(11): 2687 - 2695. [Abstract] [Full Text] [PDF]

				W Hampe, J Urny, I Franke, S. Hoffmeister-Ullerich, D Herrmann, C. Petersen, J Lohmann, and H. Schaller A head-activator binding protein is present in hydra in a soluble and a membrane-anchored form Development, January 9, 1999; 126(18): 4077 - 4086. [Abstract] [PDF]

				K. Kuhlbrodt, B. Herbarth, E. Sock, I. Hermans-Borgmeyer, and M. Wegner Sox10, a Novel Transcriptional Modulator in Glial Cells J. Neurosci., January 1, 1998; 18(1): 237 - 250. [Abstract] [Full Text] [PDF]

				K. A. Lindstedt, M. G. Mahon, R. Foisner, M. Hermann, J. Nimpf, and W. J. Schneider Receptor-associated Protein in an Oviparous Species Is Correlated with the Expression of a Receptor Variant J. Biol. Chem., November 28, 1997; 272(48): 30221 - 30227. [Abstract] [Full Text] [PDF]

				L. Jacobsen, P. Madsen, C. Jacobsen, M. S. Nielsen, J. Gliemann, and C. M. Petersen Activation and Functional Characterization of the Mosaic Receptor SorLA/LR11 J. Biol. Chem., June 15, 2001; 276(25): 22788 - 22796. [Abstract] [Full Text] [PDF]

				Y. Zhu, H. Bujo, H. Yamazaki, S. Hirayama, T. Kanaki, K. Takahashi, M. Shibasaki, W. J. Schneider, and Y. Saito Enhanced Expression of the LDL Receptor Family Member LR11 Increases Migration of Smooth Muscle Cells In Vitro Circulation, April 16, 2002; 105(15): 1830 - 1836. [Abstract] [Full Text] [PDF]