Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:605-619
© 1997 American Heart Association, Inc.
Articles |
Manipulating Angiogenesis
From Basic Science to the Bedside
From the Department of Morphology, University Medical Center, Geneva, Switzerland.
Correspondence to Michael S. Pepper, MD, PhD, Département de Morphologie, Centre Médical Universitaire, 1 rue Michel-Servet, 1211 Genève 4, Switzerland. E-mail michael.pepper{at}medecine.unige.ch
Abstract Considerable progress has been made recently in understanding the molecular mechanisms of angiogenesis, which like most other biological processes is the result of subtle and often complex interactions between molecules that have regulatory (eg, cytokines and their receptors) and effector (eg, extracellular matrix, integrins, and proteases) functions. The title of this review was chosen to reflect a recent trend in which knowledge acquired through a molecular/cell biological approach is being rapidly transferred to the clinical setting. As a result, by manipulating angiogenesis either positively or negatively, considerable therapeutic benefit can now be envisaged in physiological and pathological settings in which neovascularization is a prominent component.
Key Words: blood vessels • antiangiogenesis • protease • ischemia • therapeutic angiogenesis • tumor • cytokine
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