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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:3326-3331.)
© 1997 American Heart Association, Inc.

Articles

Interaction of Diet and Genes in Atherogenesis Report of an NHLBI Working Group

Alan Tall; Carrie Welch; Deborah Applebaum-Bowden; Momtaz Wassef; ; and the Working Group

From the Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York (A.T., C.W.); the National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, Maryland (D.A.B., M.W.). The participants of the working group are: Alan Tall, MD (Chair), Department of Medicine, College of Physicians & Surgeons of Columbia University, New York, NY 10032; John M. Dietschy, MD, University of Texas Health Science Center, Southwestern Medical School, Dallas, TX 75235; Scott M. Grundy, MD, PhD, Center for Human Nutrition, University of Texas Health Center, Dallas, TX 75235; Aldons J. Lusis, PhD Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90024; P. Ruth McPherson, MD, PhD, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4E9; Timothy F. Osborne, PhD, Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92717; Lawrence L. Rudel, PhD Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27517; Ernst J. Schaefer, MD, Lipid Metabolism Laboratory, Tufts University, Boston, MA 02111; NHLBI Staff: Momtaz Wassef, PhD, Deborah Applebaum-Bowden, PhD, Atherosclerosis Research Group, Abby Ershow, Sc.D., Cardiovascular Homeostasis and Bionutrition Research Group, Division of Heart and Vascular Diseases, Rockledge II, MSC 7956, Bethesda, MD 20892.

Abstract Recent advances in genetics and information emerging from the Human Genome Project make it feasible to examine the importance of dietary-genetic interactions in the development of atherosclerosis. In the opinion of the Working Group, three approaches are necessary to examine this concern. The first approach utilizes animal models to map and identify candidate genes involved in dietary responsiveness and atherogenesis. The second approach involves the evaluation of these genes in specific physiological processes involved in dietary responsiveness and atherogenesis. Finally, the third approach is to extend the studies performed in animal models to human populations using linkage or association studies.

Key Words: atherogenesis • diet • genes

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