© 1997 American Heart Association, Inc.
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Beneficial Effects of Alcohol Withdrawal on LDL Particle Size Distribution and Oxidative Susceptibility in Subjects With Alcohol-Induced Hypertriglyceridemia
From the First Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Correspondence to Makoto Ayaori, MD, First Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359, Japan. E-mail ayaori{at}ba2.so-net.or.jp
Abstract LDL subclass pattern B, reported to have a higher
prevalence in hypertriglyceridemics (HTGs),
is considered to be associated with an increased risk for
coronary artery disease, and the small dense LDL characteristic
of this pattern is susceptible to oxidative modification. Alcohol is
considered one of the most frequent causes of increases in plasma
triglyceride (TG) levels. We investigated the effects of
alcohol withdrawal on LDL subclass distribution and oxidizability in
drinkers with different plasma TG levels. Thirty-seven male subjects
with relatively heavy alcohol-consumption habits were divided into four
groups; normotriglyceridemic (NTG)/withdrawal
(n=11), NTG/control (n=8),
hypertriglyceridemic (HTG)/withdrawal
(n=10), and HTG/control (n=8). Both withdrawal groups abstained form
alcohol for 4 weeks, while the control subjects maintained their usual
intake of alcohol. Peak LDL particle diameter (PPD) was smaller in the
combined HTG groups than in the combined NTG groups before abstinence,
although PPD increased significantly (P<.01) from 25.5 to
26.1 nm in the HTG/withdrawal group. Before abstinence, lag times
preceding LDL oxidation in the combined HTG groups were shorter than in
the combined NTG groups; after withdrawal, lag time was prolonged
significantly (P<.01) from 49.9 to 57.3 minutes in the
HTG-withdrawal group. No significant changes in PPD and lag time were
observed in the other three groups. Significant correlations
(P<.05) were observed between the change (
) in lag time
and TG and between lag time and PPD. We conclude that in
alcohol-induced HTG subjects, alcohol withdrawal has beneficial effects
on the LDL profile by shifting the particle size from smaller to larger
and decreasing its susceptibility to oxidation.
Key Words: alcohol withdrawal • LDL subclass distribution • LDL particle size • LDL oxidizability • hypertriglyceridemia
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