Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:2309-2315
© 1997 American Heart Association, Inc.
Articles |
Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease
From the Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia.
Correspondence to Dr G.A. FitzGerald, Center for Experimental Therapeutics, University of Pennsylvania, 905 Stellar-Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104-6100. E-mail garret{at}spirit.gcrc.upenn.edu
Abstract Isoprostanes are emerging as a new class of
biologically active products of arachidonic acid
metabolism of potential relevance to human vascular
disease. Their formation in vivo seems to reflect primarily, if not
exclusively, a nonenzymatic process of lipid peroxidation. Enhanced
urinary excretion of 8-iso-PGF2
has been described in association with cardiac reperfusion injury and
with cardiovascular risk factors, including cigarette
smoking, diabetes mellitus, and
hypercholesterolemia. Besides providing a
likely noninvasive index of lipid peroxidation in these settings,
measurements of specific F2 isoprostanes in urine may
provide a sensitive biochemical end point for dose-finding studies of
natural and synthetic inhibitors of lipid peroxidation.
Although the biological effects of
8-iso-PGF2 in vitro suggest that
it and other isoeicosanoids may modulate the functional consequences of
lipid peroxidation, evidence that this is likely in vivo remains
inadequate at this time.
Key Words: F2 isoprostanes • lipid peroxidation • ischemia/reperfusion • hypercholesterolemia • cigarette smoking
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