Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:2309-2315
© 1997 American Heart Association, Inc.
Articles |
Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease
From the Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia.
Correspondence to Dr G.A. FitzGerald, Center for Experimental Therapeutics, University of Pennsylvania, 905 Stellar-Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104-6100. E-mail garret{at}spirit.gcrc.upenn.edu
Abstract Isoprostanes are emerging as a new class of
biologically active products of arachidonic acid
metabolism of potential relevance to human vascular
disease. Their formation in vivo seems to reflect primarily, if not
exclusively, a nonenzymatic process of lipid peroxidation. Enhanced
urinary excretion of 8-iso-PGF2
has been described in association with cardiac reperfusion injury and
with cardiovascular risk factors, including cigarette
smoking, diabetes mellitus, and
hypercholesterolemia. Besides providing a
likely noninvasive index of lipid peroxidation in these settings,
measurements of specific F2 isoprostanes in urine may
provide a sensitive biochemical end point for dose-finding studies of
natural and synthetic inhibitors of lipid peroxidation.
Although the biological effects of
8-iso-PGF2 in vitro suggest that
it and other isoeicosanoids may modulate the functional consequences of
lipid peroxidation, evidence that this is likely in vivo remains
inadequate at this time.
Key Words: F2 isoprostanes • lipid peroxidation • ischemia/reperfusion • hypercholesterolemia • cigarette smoking
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F. Cipollone, G. Ciabattoni, P. Patrignani, M. Pasquale, D. Di Gregorio, T. Bucciarelli, G. Davi, F. Cuccurullo, and C. Patrono Oxidant Stress and Aspirin-Insensitive Thromboxane Biosynthesis in Severe Unstable Angina Circulation, August 29, 2000; 102(9): 1007 - 1013. [Abstract] [Full Text] [PDF]
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P. Patrignani, M. R. Panara, S. Tacconelli, F. Seta, T. Bucciarelli, G. Ciabattoni, P. Alessandrini, A. Mezzetti, G. Santini, M. G. Sciulli, et al. Effects of Vitamin E Supplementation on F2-Isoprostane and Thromboxane Biosynthesis in Healthy Cigarette Smokers Circulation, August 1, 2000; 102(5): 539 - 545. [Abstract] [Full Text] [PDF]
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A. J. Cayatte, Y. Du, J. Oliver-Krasinski, G. Lavielle, T. J. Verbeuren, and R. A. Cohen The Thromboxane Receptor Antagonist S18886 but Not Aspirin Inhibits Atherogenesis in Apo E-Deficient Mice : Evidence That Eicosanoids Other Than Thromboxane Contribute to Atherosclerosis Arterioscler Thromb Vasc Biol, July 1, 2000; 20(7): 1724 - 1728. [Abstract] [Full Text] [PDF]
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L. P. Audoly, B. Rocca, J.-E. Fabre, B. H. Koller, D. Thomas, A. L. Loeb, T. M. Coffman, and G. A. FitzGerald Cardiovascular Responses to the Isoprostanes iPF2{alpha}-III and iPE2-III Are Mediated via the Thromboxane A2 Receptor In Vivo Circulation, June 20, 2000; 101(24): 2833 - 2840. [Abstract] [Full Text] [PDF]
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A. C. Staff, T. Ranheim, T. Henriksen, and B. Halvorsen 8-Iso-Prostaglandin F2{alpha} Reduces Trophoblast Invasion and Matrix Metalloproteinase Activity Hypertension, June 1, 2000; 35(6): 1307 - 1313. [Abstract] [Full Text] [PDF]
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 M. Christofidou-Solomidou, G. G. Pietra, C. C. Solomides, E. Arguiris, D. Harshaw, G. A. Fitzgerald, S. M. Albelda, and V. R. Muzykantov Immunotargeting of glucose oxidase to endothelium in vivo causes oxidative vascular injury in the lungs Am J Physiol Lung Cell Mol Physiol, April 1, 2000; 278(4): L794 - L805. [Abstract] [Full Text] [PDF]
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C. Palombo, V. Lubrano, and T. Sampietro Oxidative stress, F2-isoprostanes and endothelial dysfunction in hypercholesterolemia Cardiovasc Res, December 1, 1999; 44(3): 474 - 476. [Full Text] [PDF]
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S. H. Wilson, P. J.M. Best, L. O. Lerman, D. R. Holmes Jr., D. M. Richardson, and A. Lerman Enhanced coronary vasoconstriction to oxidative stress product, 8-epi-prostaglandinF2{alpha}, in experimental hypercholesterolemia Cardiovasc Res, December 1, 1999; 44(3): 601 - 607. [Abstract] [Full Text] [PDF]
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 H. Li, J. A. Lawson, M. Reilly, M. Adiyaman, S.-W. Hwang, J. Rokach, and G. A. FitzGerald Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F2-isoprostanes in human urine PNAS, November 9, 1999; 96(23): 13381 - 13386. [Abstract] [Full Text] [PDF]
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K. H van het Hof, I. A Brouwer, C. E West, E. Haddeman, R. P. Steegers-Theunissen, M. van Dusseldorp, J. A Weststrate, T. K. Eskes, and J. G. Hautvast Bioavailability of lutein from vegetables is 5 times higher than that of {beta}-carotene Am. J. Clinical Nutrition, August 1, 1999; 70(2): 261 - 268. [Abstract] [Full Text] [PDF]
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M. Reza Mehrabi, C. Ekmekcioglu, F. Tatzber, A. Oguogho, R. Ullrich, A. Morgan, F. Tamaddon, M. Grimm, H. D Glogar, and H. Sinzinger The isoprostane, 8-epi-PGF2{alpha}, is accumulated in coronary arteries isolated from patients with coronary heart disease Cardiovasc Res, August 1, 1999; 43(2): 492 - 499. [Abstract] [Full Text] [PDF]
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J. W. HEINECKE Mass spectrometric quantification of amino acid oxidation products in proteins: insights into pathways that promote LDL oxidation in the human artery wall FASEB J, July 1, 1999; 13(10): 1113 - 1120. [Abstract] [Full Text]
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W. Siess, K. J. Zangl, M. Essler, M. Bauer, R. Brandl, C. Corrinth, R. Bittman, G. Tigyi, and M. Aepfelbacher Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions PNAS, June 8, 1999; 96(12): 6931 - 6936. [Abstract] [Full Text] [PDF]
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S. Voutilainen, J. D. Morrow, L. J. Roberts II, G. Alfthan, H. Alho, K. Nyyssonen, and J. T. Salonen Enhanced In Vivo Lipid Peroxidation at Elevated Plasma Total Homocysteine Levels Arterioscler Thromb Vasc Biol, May 1, 1999; 19(5): 1263 - 1266. [Abstract] [Full Text] [PDF]
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G. Davi, G. Ciabattoni, A. Consoli, A. Mezzetti, A. Falco, S. Santarone, E. Pennese, E. Vitacolonna, T. Bucciarelli, F. Costantini, et al. In Vivo Formation of 8-Iso-Prostaglandin F2{alpha} and Platelet Activation in Diabetes Mellitus : Effects of Improved Metabolic Control and Vitamin E Supplementation Circulation, January 19, 1999; 99(2): 224 - 229. [Abstract] [Full Text] [PDF]
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C. Chiabrando, A. Valagussa, C. Rivalta, T. Durand, A. Guy, E. Zuccato, P. Villa, J.-C. Rossi, and R. Fanelli Identification and Measurement of Endogenous beta -Oxidation Metabolites of 8-epi-Prostaglandin F2alpha J. Biol. Chem., January 15, 1999; 274(3): 1313 - 1319. [Abstract] [Full Text] [PDF]
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C. Leeuwenburgh, P. A. Hansen, J. O. Holloszy, and J. W. Heinecke Oxidized amino acids in the urine of aging rats: potential markers for assessing oxidative stress in vivo Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R128 - R135. [Abstract] [Full Text] [PDF]
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J. L. Witztum To E or Not To E—How Do We Tell? Circulation, December 22, 1998; 98(25): 2785 - 2787. [Full Text] [PDF]
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M. P. Reilly, D. Pratico, N. Delanty, G. DiMinno, E. Tremoli, D. Rader, S. Kapoor, J. Rokach, J. Lawson, and G. A. FitzGerald Increased Formation of Distinct F2 Isoprostanes in Hypercholesterolemia Circulation, December 22, 1998; 98(25): 2822 - 2828. [Abstract] [Full Text] [PDF]
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D. Praticò, V. M.-Y.Lee, J. Q. Trojanowski, J. Rokach, and G. A. Fitzgerald Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo FASEB J, December 1, 1998; 12(15): 1777 - 1783. [Abstract] [Full Text]
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J. A. Lawson, H. Li, J. Rokach, M. Adiyaman, S.-W. Hwang, S. P. Khanapure, and G. A. FitzGerald Identification of Two Major F2 Isoprostanes, 8,12-Iso- and 5-epi-8,12-Iso-isoprostane F2alpha -VI, in Human Urine J. Biol. Chem., November 6, 1998; 273(45): 29295 - 29301. [Abstract] [Full Text] [PDF]
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P. MONTUSCHI, G. C. TONI, P. PAREDI, P. PANTELIDIS, R. M. du BOIS, S. A. KHARITONOV, and P. J. BARNES 8-Isoprostane as a Biomarker of Oxidative Stress in Interstitial Lung Diseases Am. J. Respir. Crit. Care Med., November 1, 1998; 158(5): 1524 - 1527. [Abstract] [Full Text] [PDF]
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I. Jialal Evolving lipoprotein risk factors: lipoprotein(a) and oxidized low-density lipoprotein Clin. Chem., August 1, 1998; 44(8): 1827 - 1832. [Abstract] [Full Text] [PDF]
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D. Pratico, O. P. Barry, J. A. Lawson, M. Adiyaman, S.-W. Hwang, S. P. Khanapure, L. Iuliano, J. Rokach, and G. A. FitzGerald IPF2alpha -I: An index of lipid peroxidation in humans PNAS, March 31, 1998; 95(7): 3449 - 3454. [Abstract] [Full Text] [PDF]
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E. A. Weinstein, H. Li, J. A. Lawson, J. Rokach, G. A. FitzGerald, and P. H. Axelsen Prothrombinase Acceleration by Oxidatively Damaged Phospholipids J. Biol. Chem., July 21, 2000; 275(30): 22925 - 22930. [Abstract] [Full Text] [PDF]
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R. K. Tangirala, D. Pratico, G. A. FitzGerald, S. Chun, K. Tsukamoto, C. Maugeais, D. C. Usher, E. Pure, and D. J. Rader Reduction of Isoprostanes and Regression of Advanced Atherosclerosis by Apolipoprotein E J. Biol. Chem., January 5, 2001; 276(1): 261 - 266. [Abstract] [Full Text] [PDF]
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