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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:2188-2191.)
© 1997 American Heart Association, Inc.

Articles

The Angiotensin-Converting Enzyme Gene and the Angiotensin II Type I Receptor Gene as Candidate Genes for Microalbuminuria

A Study in Nondiabetic and Non–Insulin-Dependent Diabetic Subjects

John S. Yudkin; Christine Andres; Vidya Mohamed-Ali; Mairi Gould; Arshia Panahloo; Andrew P. Haines; Steve Humphries; ; Phillippa Talmud

From the Departments of Medicine (J.S.Y., C.A., V.M.-A., A.P.) and Primary Health Care (M.G., A.P.H.), Whittington Hospital; and the Division of Cardiovascular Genetics, Department of Medicine, Rayne Institute (S.H., P.T.), University College London Medical School, UK.

Abstract Familial clustering of microalbuminuria with cardiovascular disease suggests a possible common genetic antecedent. We have tested the hypothesis that the angiotensin-converting enzyme (ACE) DD genotype and the angiotensin II type I receptor (AT₁R) gene C allele represent the common link between microalbuminuria and coronary heart disease. The frequency of polymorphisms of the ACE and AT₁R genes were investigated in 509 nondiabetic white subjects and in 86 non–insulin-dependent diabetic white patients. There was no significant difference in albumin excretion rate between the genotypes in nondiabetic subjects on either a daytime or an overnight sample or in diabetic subjects expressed as a normalized albumin concentration on an untimed morning urine collection. We have found no evidence for an association between polymorphism of the ACE or AT₁R genes and microalbuminuria in two groups of subjects without insulin-dependent diabetes.

Key Words: cardiovascular disease • microalbuminuria • non–insulin-dependent diabetes • angiotensin-converting enzyme gene • angiotensin II type I receptor gene

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