Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:1879-1884
© 1997 American Heart Association, Inc.
Articles |
Hepatic Lipase Gene Polymorphisms Influence Plasma HDL Levels
Results From Finnish EARS Participants
From the Department of Biochemistry, National Public Health Institute, Helsinki (S.M., E.T., M.A., C.E.), and the Children's Hospital, University of Helsinki (M.A.), Finland; INSERM U258, Epidemiologie Cardiovasculaire, Hôpital Broussais, Paris, France (L.T., V.N.); and the Department of Biochemistry and Internal Medicine, Erasmus University, Rotterdam, The Netherlands (H.J.).
Correspondence to Christian Ehnholm, Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland.
Abstract Hepatic lipase (HL), a triglyceride lipase found in liver, adrenals, testes, and ovaries, takes part in the uptake, remodeling, and function of lipoproteins including HDL, as well as VLDL and chylomicrons. In the present study, the genotype distribution of five HL polymorphisms (-C480T, V133V, T202T, L334F, T457T) and their association to plasma lipid values were investigated. The study participants included 92 students with paternal history of myocardial infarction before the age of 55 and 194 matched control subjects, ie, the Finnish participants of the European Atherosclerosis Research Study (EARS). The allele T of the HL polymorphism -C480T showed an association with elevated HDL, apoA-I, and LpA-I values (ANOVA P<.01). No difference in genotype distribution was observed in the offspring with and without paternal history of myocardial infarction.
Key Words: polymorphism • hepatic lipase • high-density lipoproteins • atherosclerosis • European Atherosclerosis Research Study
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