© 1996 American Heart Association, Inc.
Articles |
Correlates of Thrombin Markers in an Elderly Cohort Free of Clinical Cardiovascular Disease
the Departments of Pathology (M.C., E.M., E.G.B., E.S.C., R.P.T.), Medicine (M.C.), and Biochemistry (R.P.T.), University of Vermont, Colchester; the Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle (B.M.P.); and the Departments of Medicine and Epidemiology, University of Pittsburgh, Pa (L.H.K.).
Correspondence to Russell P. Tracy, PhD, University of Vermont, Aquatec Building, T205, 55A South Park Dr, Colchester, VT 05446. E-mail rtracy@moose.uvm.edu.
Studies suggest that thrombosis is important in the progression of atherosclerotic lesions. The biochemical markers prothrombin fragment 1-2 and fibrinopeptide A reflect in vivo thrombin generation and activity, respectively. As such, they are markers that might be associated with cardiovascular risk. From the Cardiovascular Health Study, a cohort study of 5201 persons over 65 years of age, 399 persons free of clinical cardiovascular disease (CVD) at the baseline examination were selected for study of specialized markers of hemostasis. We report the cross-sectional relationships of the thrombin markers to CVD risk factors and measures of subclinical CVD. The range of fragment 1-2 was 0.12 to 0.85 nmol/L. The range of fibrinopeptide A was 0.9 to 44.1 µg/L. High levels of fragment 1-2 and fibrinopeptide A were associated with age, with levels higher in women than men. Fragment 1-2 was associated with smoking; high levels of triglyceride, creatinine, and C-reactive protein; and low levels of glucose. Fibrinopeptide A was associated with high C-reactive protein and apolipoprotein(a) and lower ankle-brachial index. There were no significant associations of the thrombin markers with race, fibrinogen, alcohol consumption, diabetes, or most measures of subclinical CVD. Study findings support a hypothesis that there are physiological interrelationships between cardiac risk factors, hemostasis, inflammation, and progression of atherosclerosis.
Key Words: cardiovascular disease • fibrinopeptide A • blood coagulation factors • prothrombin fragment 1-2 • aged
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