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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1996;16:864-867.)
© 1996 American Heart Association, Inc.

Articles

Antithrombin and Atherosclerosis in the Rotterdam Study

J.G. van der Bom; M.L. Bots; H.H.D.M. van Vliet; H.A.P. Pols; A. Hofman; D.E. Grobbee

the Departments of Epidemiology and Biostatistics (J.G. van der B., M.L.B., A.H., D.E.G.); Netherlands Institute for Health Sciences (J.G. van der B.); Hematology (Hemostasis and Thrombosis Research) (H.H.D.M. van V.); and Internal Medicine III (H.A.P.P.), Erasmus University Medical School, Rotterdam, Netherlands.

Correspondence to Professor D.E. Grobbee, Department of Epidemiology and Biostatistics, Erasmus University Medical School, PO Box 1738, 3000 DR Rotterdam, Netherlands.

Antithrombin is a potent inhibitor of thrombotic tendency. Whether atherosclerotic disease is associated with high or low antithrombin is unclear. Studies of the relation between antithrombin and presence of arterial disease have shown contrasting results. In the Rotterdam Study, a single-center, population-based cohort study of 7983 subjects aged 55 years and older, the association between atherosclerosis and antithrombin was evaluated. The ratio of ankle to arm blood pressure is a graded marker for atherosclerosis and provides the opportunity to investigate nonlinear associations. In the first 1427 participants of the Rotterdam Study who did not use anticoagulants, both antithrombin and the ratio of ankle to arm blood pressure were measured. In men the association between the two was quadratic: antithrombin activity was increased in men with moderate peripheral arterial atherosclerosis compared with those without, and in men with more severe atherosclerosis it was decreased. In women the association was linear: a decreased ratio of ankle to arm pressure was associated with increased antithrombin activity. These associations were independent of smoking, body mass index, serum lipids, fibrinogen, and factor VIIc. We propose that antithrombin activity rises in response to increased risk of cardiovascular disease and also in response to the presence of atherosclerosis, whereas antithrombin may decrease with increasing severity of the atherosclerotic process in men. This may explain the contrasting results found in previous studies. Changes in antithrombin over time might be useful in predicting the risk of cardiovascular disease and progression.

Key Words: hemostasis • cardiovascular disease • risk • coagulation

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