© 1996 American Heart Association, Inc.
Articles |
Plasma Homocysteine and Severity of Atherosclerosis in Young Patients With Lower-Limb Atherosclerotic Disease
From the Institute for Cardiovascular Research, Department of Vascular Surgery (M. van den B., E.B., J.A.R.), and Department of Internal Medicine (C.D.A.S.) of the Free University Hospital, Amsterdam, Netherlands.
Abstract Elevated plasma homocysteine levels are recognized as an independent risk factor for atherosclerotic disease. It is not known (1) whether the severity of atherosclerotic disease is related to hyperhomocyst(e)inemia or (2) whether any such relation differs between fasting and post–methionine loading plasma homocysteine levels. Therefore, in 171 consecutive patients under 55 years of age with first symptoms of lower-limb disease, we examined the relation between severity of atherosclerosis and plasma homocysteine concentration. Severity of atherosclerotic disease was estimated from the prevalence of coronary artery disease and cerebrovascular disease and from the angiographic extent of lower-limb disease. Plasma homocysteine was measured after a period of fasting and in response to methionine loading (0.1 g/kg). In multivariate analysis, the prevalence of coronary artery disease plus cerebrovascular disease was related to both fasting and postmethionine homocysteine levels (odds ratio [OR] for the upper quartile versus the lower three quartiles, 2.8, 95% confidence interval [CI], 1.1 to 7.5; and OR 3.0, 95% CI, 1.1 to 7.8, respectively). The extent of lower-limb disease was weakly related to the fasting homocysteine level (partial correlation coefficient, .12; P=.17) and more strongly related to the postmethionine homocysteine level (partial correlation coefficient, .25; P=.003). These relations tended to be more pronounced in women than in men. They were independent of age, total serum cholesterol, blood pressure, and smoking habit. We concluded that the severity of atherosclerotic disease in young patients with lower-limb atherosclerotic disease is associated with high postmethionine and fasting homocysteine concentrations.
Key Words: homocysteine • severity • atherosclerosis • gender • methionine
This article has been cited by other articles:
 |
|
 |
|
  A. S Wierzbicki Homocysteine and cardiovascular disease: a review of the evidence Diabetes and Vascular Disease Research, June 1, 2007; 4(2): 143 - 149. [Abstract] [PDF]
|
|
|
|
 |
|
 I. J. Kullo, G. Li, L. F. Bielak, K. R. Bailey, P. F. Sheedy II, P. A. Peyser, S. T. Turner, and S. L. R. Kardia Association of Plasma Homocysteine With Coronary Artery Calcification in Different Categories of Coronary Heart Disease Risk Mayo Clin. Proc., February 1, 2006; 81(2): 177 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R Olthof, E. J Brink, M. B Katan, and P. Verhoef Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men Am. J. Clinical Nutrition, July 1, 2005; 82(1): 111 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ziegler, F. Mittermayer, C. Plank, E. Minar, M. Wolzt, and G.-H. Schernthaner Homocyst(e)ine-Lowering Therapy Does Not Affect Plasma Asymmetrical Dimethylarginine Concentrations in Patients with Peripheral Artery Disease J. Clin. Endocrinol. Metab., April 1, 2005; 90(4): 2175 - 2178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Olthof, T. van Vliet, E. Boelsma, and P. Verhoef Low Dose Betaine Supplementation Leads to Immediate and Long Term Lowering of Plasma Homocysteine in Healthy Men and Women J. Nutr., December 1, 2003; 133(12): 4135 - 4138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Aso, K.-i. Okumura, K. Takebayashi, S. Wakabayashi, and T. Inukai Relationships of Plasma Interleukin-18 Concentrations to Hyperhomocysteinemia and Carotid Intimal-Media Wall Thickness in Patients With Type 2 Diabetes Diabetes Care, September 1, 2003; 26(9): 2622 - 2627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Stuhlinger, R. K. Oka, E. E. Graf, I. Schmolzer, B. M. Upson, O. Kapoor, A. Szuba, M. R. Malinow, T. C. Wascher, O. Pachinger, et al. Endothelial Dysfunction Induced by Hyperhomocyst(e)inemia: Role of Asymmetric Dimethylarginine Circulation, August 26, 2003; 108(8): 933 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Weiss, C. Keller, U. Hoffmann, and J. Loscalzo Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia Vascular Medicine, August 1, 2002; 7(3): 227 - 239. [Abstract] [PDF]
|
|
|
|
 |
|
 K. R Dimitrova, K. DeGroot, A. K Myers, and Y. D Kim Estrogen and homocysteine Cardiovasc Res, February 15, 2002; 53(3): 577 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. van der Griend, D. H Biesma, and J.-D. Banga Postmethionine-load homocysteine determination for the diagnosis hyperhomocysteinaemia and efficacy of homocysteine lowering treatment regimens Vascular Medicine, February 1, 2002; 7(1): 29 - 33. [Abstract] [PDF]
|
|
|
|
 |
|
 R. A.J.M. van Dijk, J. A. Rauwerda, M. Steyn, J. W.R. Twisk, and C. D.A. Stehouwer Long-Term Homocysteine-Lowering Treatment With Folic Acid Plus Pyridoxine Is Associated With Decreased Blood Pressure but Not With Improved Brachial Artery Endothelium-Dependent Vasodilation or Carotid Artery Stiffness: A 2-Year, Randomized, Placebo-Controlled Trial Arterioscler Thromb Vasc Biol, December 1, 2001; 21(12): 2072 - 2079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. G. J. Vermeulen, H. W. M. Niessen, M. Bogels, C. D. A. Stehouwer, J. A. Rauwerda, and V. W. M. van Hinsbergh Decreased Smooth Muscle Cell/Extracellular Matrix Ratio of Media of Femoral Artery in Patients With Atherosclerosis and Hyperhomocysteinemia Arterioscler Thromb Vasc Biol, April 1, 2001; 21(4): 573 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Brattstrom and D. E. Wilcken Homocysteine and cardiovascular disease: cause or effect? Am. J. Clinical Nutrition, August 1, 2000; 72(2): 315 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Foody, J. A. Milberg, K. Robinson, G. L. Pearce, D. W. Jacobsen, and D. L. Sprecher Homocysteine and Lipoprotein(a) Interact to Increase CAD Risk in Young Men and Women Arterioscler Thromb Vasc Biol, February 1, 2000; 20(2): 493 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. H. Yu, R. Joubran, M. Asmi, T. Law, A. Spencer, M. Jouma, and N. Rifai Agreement among Four Homocysteine Assays and Results in Patients with Coronary Atherosclerosis and Controls Clin. Chem., February 1, 2000; 46(2): 258 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Bova, J. Chapman, C. Sylantiev, A. D. Korczyn, and N. M. Bornstein The A677V Methylenetetrahydrofolate Reductase Gene Polymorphism and Carotid Atherosclerosis Stroke, October 1, 1999; 30(10): 2180 - 2182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Bortolotto, M. E. Safar, E. Billaud, C. Lacroix, R. Asmar, G. M. London, and J. Blacher Plasma Homocysteine, Aortic Stiffness, and Renal Function in Hypertensive Patients Hypertension, October 1, 1999; 34(4): 837 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Eikelboom, E. Lonn, J. Genest Jr., G. Hankey, and S. Yusuf Homocyst(e)ine and Cardiovascular Disease: A Critical Review of the Epidemiologic Evidence Ann Intern Med, September 7, 1999; 131(5): 363 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. de Jong, C. D. A. Stehouwer, M. van den Berg, P. J. Kostense, D. Alders, C. Jakobs, G. Pals, and J. A. Rauwerda Determinants of Fasting and Post-Methionine Homocysteine Levels in Families Predisposed to Hyperhomocysteinemia and Premature Vascular Disease Arterioscler Thromb Vasc Biol, May 1, 1999; 19(5): 1316 - 1324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Malinow, A. G. Bostom, and R. M. Krauss Homocyst(e)ine, Diet, and Cardiovascular Diseases : A Statement for Healthcare Professionals From the Nutrition Committee, American Heart Association Circulation, January 12, 1999; 99(1): 178 - 182. [Full Text] [PDF]
|
|
|
|
|
|
C. D. A. Stehouwer, M. P. Weijenberg, M. van den Berg, C. Jakobs, E. J. M. Feskens, and D. Kromhout Serum Homocysteine and Risk of Coronary Heart Disease and Cerebrovascular Disease in Elderly Men : A 10-Year Follow-Up Arterioscler Thromb Vasc Biol, December 1, 1998; 18(12): 1895 - 1901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Moghadasian, B. M. McManus, and J. J. Frohlich Homocyst(e)ine and Coronary Artery Disease: Clinical Evidence and Genetic and Metabolic Background Arch Intern Med, November 10, 1997; 157(20): 2299 - 2308. [Abstract] [PDF]
|
|
|
|
|
|
S. C. de Jong, C. D. A. Stehouwer, A. J. C. Mackaay, M. van den Berg, E. J. Bulterijs, F. C. Visser, J. Bax, and J. A. Rauwerda High Prevalence of Hyperhomocysteinemia and Asymptomatic Vascular Disease in Siblings of Young Patients With Vascular Disease and Hyperhomocysteinemia Arterioscler Thromb Vasc Biol, November 1, 1997; 17(11): 2655 - 2662. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. J. Kluijtmans, J. J. P. Kastelein, J. Lindemans, G. H. J. Boers, S. G. Heil, A. V. G. Bruschke, J. W. Jukema, L. P. W. J. van den Heuvel, F. J. M. Trijbels, G. J. M. Boerma, et al. Thermolabile Methylenetetrahydrofolate Reductase in Coronary Artery Disease Circulation, October 21, 1997; 96(8): 2573 - 2577. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Undas, E. B. Williams, S. Butenas, T. Orfeo, and K. G. Mann Homocysteine Inhibits Inactivation of Factor Va by Activated Protein C J. Biol. Chem., February 2, 2001; 276(6): 4389 - 4397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. J. Bot, F. Barkhof, G. L. a Nijeholt, D. van Schaardenburg, A. E. Voskuyl, H. J. Ader, J. A. L. Pijnenburg, C. H. Polman, B. M. J. Uitdehaag, E. G. J. Vermeulen, et al. Differentiation of Multiple Sclerosis from Other Inflammatory Disorders and Cerebrovascular Disease: Value of Spinal MR Imaging Radiology, April 1, 2002; 223(1): 46 - 56. [Abstract] [Full Text] [PDF]
|
|