This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Klausen, I. C. Articles by Faergeman, O. Search for Related Content PubMed PubMed Citation Articles by Klausen, I. C. Articles by Faergeman, O. Pubmed/NCBI databases Medline Plus Health Information Heart Attack

(Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:1001-1008.)
© 1995 American Heart Association, Inc.

Articles

Apo(a) Phenotypes and Lp(a) Concentrations in Offspring of Men With and Without Myocardial Infarction

The EARS Study

Ib Christian Klausen; Ulrike Beisiegel; Hans-Jürgen Menzel; Maryvonne Rosseneu; Viviane Nicaud; Ole Faergeman; on behalf of the EARS Group

From the EARS Group (see "Appendix" for list of study participants).

Abstract In the European Atherosclerosis Research Study, genetic and environmental markers of risk of premature coronary heart disease were compared in offspring of men with and without myocardial infarction before the age of 55 years. Cases were 682 students with a paternal history of myocardial infarction, and control subjects were 1312 students without such a history. The students were enrolled in 14 universities in five European regions (Finland, Great Britain, and northern, middle, and southern Europe). Lipoprotein(a) [Lp(a)] concentrations were skewed towards lower concentrations in both cases (median, 7.3 mg/dL; 95% confidence interval, 6.3 to 8.1 mg/dL) and control subjects (median, 6.6 mg/dL; 95% confidence interval, 6.1 to 7.2 mg/dL) (P=.37). Significantly more northern European male cases than control subjects had Lp(a) levels exceeding 30 mg/dL (P=.040), but this did not pertain to females (P=.29), and overall, there was no difference between cases (16.5%) and control subjects (15.5%) in the frequency of Lp(a) concentrations above 30 mg/dL (P=.63). As expected, there was a significant (P<.01) inverse relationship between apo(a) molecular size and Lp(a) concentration. In Great Britain there was a significant difference in phenotype distribution between cases and control subjects (P=.035), due mainly to a high frequency of the apo(a) S2 isoform in cases. A similar but statistically insignificant tendency was seen in northern Europeans. In the three other regions, however, the distribution of apo(a) phenotypes among cases and controls was similar, and in the study population overall, the distribution of apo(a) phenotypes did not differ significantly (P=.74) between cases and control subjects.

Key Words: lipoprotein(a) • apolipoprotein(a) • lipoproteins

This article has been cited by other articles:

				T. Szamosi, E. Roth, T. Szamosi Jr, E. Tomsits, A. Tordai, and T. Szabo Hyperhomocysteinemia, Enzyme Polymorphism and Thiobarbituric Acid Reactive System in Children with High Coronary Risk Family History J. Am. Coll. Nutr., October 1, 2004; 23(5): 386 - 390. [Abstract] [Full Text] [PDF]

				M. Margaglione, G. Cappucci, D. Colaizzo, G. Vecchione, E. Grandone, and G. Di Minno C-Reactive Protein in Offspring Is Associated With the Occurrence of Myocardial Infarction in First-Degree Relatives Arterioscler. Thromb. Vasc. Biol., January 1, 2000; 20(1): 198 - 203. [Abstract] [Full Text] [PDF]

				D. De Bacquer, G. De Backer, M. Kornitzer, and H. Blackburn Parental history of premature coronary heart disease mortality and signs of ischemia on the resting electrocardiogram J. Am. Coll. Cardiol., May 1, 1999; 33(6): 1491 - 1498. [Abstract] [Full Text] [PDF]

				S. E. Humphries, V. Nicaud, J. Margalef, L. Tiret, P. J. Talmud, and f. t. EARS Lipoprotein Lipase Gene Variation Is Associated With a Paternal History of Premature Coronary Artery Disease and Fasting and Postprandial Plasma Triglycerides : The European Atherosclerosis Research Study (EARS) Arterioscler. Thromb. Vasc. Biol., April 1, 1998; 18(4): 526 - 534. [Abstract] [Full Text] [PDF]