Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:821-826
© 1995 American Heart Association, Inc.
Articles |
Coronary Heart Disease Risk Factors in Women With Polycystic Ovary Syndrome
From the Department of Epidemiology (E.T., A.C., K.D., K.W., L.K.), Graduate School of Public Health, and the Department of Obstetrics, Gynecology, and Reproductive Sciences (D.G., S.B.), Magee-Womens Hospital, University of Pittsburgh, Pa.
Correspondence to Evelyn Talbott, DrPH, MPH, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St, Pittsburgh, PA 15261. E-mail eo1@ vms.cis.pitt.edu.
Abstract The goal of the study was to compare cardiovascular heart disease risk factors in women with polycystic ovary syndrome (PCOS) and matched control subjects. Women with PCOS have risk factors, including anovulation, hyperandrogenism, and insulin resistance, that suggest a male coronary heart disease risk-factor profile. A total of 206 women with PCOS were recruited by using records from a large reproductive endocrinology practice. A clinical diagnosis of PCOS was made if there was a history of chronic anovulation in association with either clinical evidence of androgen excess (hirsutism) or if total testosterone level was >2 nm/L or the luteinizing hormone/follicle-stimulating hormone ratio was greater than 2. The overall response rate for cases was 76%. A control population was obtained by using a combination of area voters' registration tapes and directories of households. A control subject was matched to each case subject by age±5 years, race, and neighborhood. The response rate for recruitment of the first or second eligible control subject was 83.6%. The average age at initial interview was 35.9±7.4 years for case and 37.2±7.8 years for control subjects. Women with PCOS had significantly increased cardiovascular disease risk factors compared with control women. These included increases in body mass index, insulin, and triglyceride levels (P<.001), decreased total HDL and HDL2 levels (P<.01), and increased total cholesterol and fasting LDL levels, waist/hip ratio, and systolic blood pressure (P<.05). After controlling for age, body mass index, and other confounding variables, differences in total cholesterol, total HDL, HDL2, LDL cholesterol, and triglycerides were still significant between case and control subjects. These risk factors were especially elevated in PCOS women in the early premenopausal years compared with control women, indicating that women with PCOS should be monitored for early detection and considered for appropriate clinical interventions.
Key Words: coronary heart disease • polycystic ovary syndrome • risk factors • case-control study
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 L. Marasco, C. Marmet, and E. Shell Polycystic Ovary Syndrome: A Connection to Insufficient Milk Supply? J Hum Lact, May 1, 2000; 16(2): 143 - 148. [Abstract] [PDF]
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D. Cibula, R. Cifkova, M. Fanta, R. Poledne, J. Zivny, and J. Skibova Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome Hum. Reprod., April 1, 2000; 15(4): 785 - 789. [Abstract] [Full Text] [PDF]
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P. L. Chang, S. R. Lindheim, C. Lowre, M. Ferin, F. Gonzalez, L. Berglund, E. Carmina, M. V. Sauer, and R. A. Lobo Normal Ovulatory Women with Polycystic Ovaries Have Hyperandrogenic Pituitary-Ovarian Responses To Gonadotropin-Releasing Hormone-Agonist Testing J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 995 - 1000. [Abstract] [Full Text]
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 P. A. Lotufo, C. U. Chae, U. A. Ajani, C. H. Hennekens, and J. E. Manson Male Pattern Baldness and Coronary Heart Disease: The Physicians' Health Study Arch Intern Med, January 24, 2000; 160(2): 165 - 171. [Abstract] [Full Text] [PDF]
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M. W. Elting, T. J.M. Korsen, L. T.M. Rekers-Mombarg, and J. Schoemaker Women with polycystic ovary syndrome gain regular menstrual cycles when ageing Hum. Reprod., January 1, 2000; 15(1): 24 - 28. [Abstract] [Full Text] [PDF]
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E. Carmina and R. A. Lobo Polycystic Ovary Syndrome (PCOS): Arguably the Most Common Endocrinopathy Is Associated with Significant Morbidity in Women J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 1897 - 1899. [Full Text]
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E. Diamanti-Kandarakis, A. Mitrakou, S. Raptis, G. Tolis, and A. J. Duleba The Effect of a Pure Antiandrogen Receptor Blocker, Flutamide, on the Lipid Profile in the Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., August 1, 1998; 83(8): 2699 - 2705. [Abstract] [Full Text]
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 Z. E C Hopkinson, N. Sattar, R. Fleming, and I. A Greer Fortnightly Review: Polycystic ovarian syndrome: the metabolic syndrome comes to gynaecology BMJ, August 1, 1998; 317(7154): 329 - 332. [Full Text]
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 A. H. Slyper Childhood Obesity, Adipose Tissue Distribution, and the Pediatric Practitioner Pediatrics, July 1, 1998; 102(1): 4e - 4. [Abstract] [Full Text]
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J. Holte, G. Gennarelli, L. Wide, H. Lithell, and C. Berne High Prevalence of Polycystic Ovaries and Associated Clinical, Endocrine, and Metabolic Features in Women with Previous Gestational Diabetes Mellitus J. Clin. Endocrinol. Metab., April 1, 1998; 83(4): 1143 - 1150. [Abstract] [Full Text]
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T. L. Daniels and S. L. Berga Resistance of Gonadotropin Releasing Hormone Drive to Sex Steroid-Induced Suppression in Hyperandrogenic Anovulation J. Clin. Endocrinol. Metab., December 1, 1997; 82(12): 4179 - 4183. [Abstract] [Full Text] [PDF]
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M. Rajkhowa, R. H. Neary, P. Kumpatla, F. L. Game, P. W. Jones, M. S. Obhrai, and R. N. Clayton Altered Composition of High Density Lipoproteins in Women with the Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., October 1, 1997; 82(10): 3389 - 3394. [Abstract] [Full Text] [PDF]
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S. M. Herman, J. T.C. Robinson, R. J. McCredie, M. R. Adams, M. J. Boyer, and D. S. Celermajer Androgen Deprivation Is Associated With Enhanced Endothelium-Dependent Dilatation in Adult Men Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 2004 - 2009. [Abstract] [Full Text]
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D. A. Ehrmann, D. J. Schneider, B. E. Sobel, M. K. Cavaghan, J. Imperial, R. L. Rosenfield, and K. S. Polonsky Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2108 - 2116. [Abstract] [Full Text] [PDF]
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G. B. Phillips, B. H. Pinkernell, and T.-Y. Jing Relationship Between Serum Sex Hormones and Coronary Artery Disease in Postmenopausal Women Arterioscler Thromb Vasc Biol, April 1, 1997; 17(4): 695 - 701. [Abstract] [Full Text]
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