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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:733-739.)
© 1995 American Heart Association, Inc.

Articles

Oxidation-Related Analytes and Lipid and Lipoprotein Concentrations in Healthy Subjects

Wendy Y. Craig; Sue E. Poulin; Glenn E. Palomaki; Louis M. Neveux; Robert F. Ritchie; Thomas B. Ledue

From the Foundation for Blood Research, Scarborough, Me.

Correspondence to Wendy Y. Craig, PhD, Foundation for Blood Research, PO Box 190, Scarborough, ME 04070-0190.

Abstract The relations between oxidation-related analytes and lipoprotein risk factors for coronary heart disease are poorly understood. To address this issue, ceruloplasmin, copper, iron, ferritin, cotinine, lipid peroxides, cholesterol, triglyceride, apoB, apoA-I, and lipoprotein(a) levels were measured in sera from apparently healthy subjects (51 men and 115 women). Pairwise comparisons revealed strong positive associations (P<.001) of copper and ceruloplasmin with lipid peroxides, total cholesterol, triglycerides and apoB, of transferrin with apoA-I and cholesterol, and of ferritin with triglycerides. Serum levels of oxidation-related analytes did not differ between smokers and nonsmokers. In multivariate analysis, serum copper was the major independent determinant of serum lipid peroxide level, accounting for 15% of the variability in concentration (ferritin accounted for 1.6%). Copper and ceruloplasmin accounted for 20.5% of the variation in triglyceride levels; triglycerides and apoB accounted for 12% of the variability in ferritin levels; apoB and apoA-I accounted for 9% of the variability in transferrin levels. The data suggest that serum copper contributes to lipid peroxidation in vivo. There are significant associations between lipoprotein and transition metal-related analytes, and further work is needed to elucidate the physiological basis for these relations.

Key Words: oxidation • lipids • apolipoproteins • transition metals

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