This Article Full Text Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Katzel, L. I. Articles by Goldberg, A. P. Search for Related Content PubMed PubMed Citation Articles by Katzel, L. I. Articles by Goldberg, A. P.

(Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:299-305.)
© 1995 American Heart Association, Inc.

Articles

Persistence of Low HDL-C Levels After Weight Reduction in Older Men With Small LDL Particles

Leslie I. Katzel; Patricia J. Coon; Ellen Rogus; Ronald M. Krauss; Andrew P. Goldberg

From the Department of Medicine, Division of Gerontology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Geriatrics Research, Education, and Clinical Center, Baltimore, Md, and the Life Sciences Division (R.M.K.), Department of Molecular and Nuclear Medicine, Lawrence Berkeley Laboratory, University of California, Berkeley.

Correspondence to Leslie I. Katzel, MD, PhD, Baltimore VA Medical Center, Geriatrics Service (18), 10 N Greene St, Baltimore, MD 21201.

Abstract LDL subclass pattern B is characterized by a predominance of small LDL particles (LDL peak particle size 255 Å) and is associated with increased plasma triglyceride (TG) and reduced HDL cholesterol (HDL-C) concentrations. This study compared the effect of weight loss on lipoprotein and glucose metabolism in 15 healthy, obese (body mass index [BMI], 30.9±2.4 kg/m²), older (60±9 years) men with LDL pattern B and in 25 men of comparable age and BMI with LDL pattern A (LDL peak particle size 260 Å). At baseline, men with LDL pattern B had higher TG and lower apolipoprotein (apo) A-I, HDL-C, and HDL₂-C levels (P<.001) than men with LDL pattern A, while the total cholesterol and LDL cholesterol levels and fasting and 2-hour postprandial glucose and insulin levels did not differ between groups. With weight loss (10.1±3.6 kg) there were significant decreases in 2-hour postprandial glucose and insulin levels in men with LDL patterns B and A (P<.05). However, the change in plasma TG, HDL-C, HDL₂-C, and apoA-I levels with weight loss differed between groups. In men with LDL pattern A, plasma TG levels decreased by 15% (P<.001) compared with a 34% (P<.001) decrease in LDL pattern B (two-factor ANOVA, P<.01). Plasma HDL-C concentrations increased by 0.16 mmol/L (P<.001) in the men with LDL pattern A but by only 0.07 mmol/L in the men with LDL pattern B (two-factor ANOVA, P<.05). After weight loss, only 5 of the 15 men with LDL pattern B had HDL-C levels above 0.90 mmol/L (35 mg/dL), whereas 22 of 25 men with LDL pattern A had HDL-C levels above 0.90 mmol/L (²=18, P<.0001). Furthermore, with weight loss, 11 of the 15 men with LDL pattern B increased their LDL peak particle diameter; 7 converted to intermediate LDL pattern, and 4 converted to LDL pattern A. By comparison, there were no significant changes in weight, lipoprotein, or apolipoprotein concentrations at 1-year follow-up in 12 metabolic control subjects. Thus, despite significant reductions in weight and body fat and concomitant decreases in plasma TG and insulin levels, HDL-C and HDL₂ subspecies levels remain low in men with LDL pattern B.

Key Words: LDL subclasses • HDL • triglycerides • insulin resistance • abdominal obesity

This article has been cited by other articles:

				J.-F. Mauger, P. Couture, N. Bergeron, and B. Lamarche Apolipoprotein C-III isoforms: kinetics and relative implication in lipid metabolism J. Lipid Res., June 1, 2006; 47(6): 1212 - 1218. [Abstract] [Full Text] [PDF]

				K. C. Maki, M. H. Davidson, M. S. Cyrowski, A. C. Maki, and P. Marx Low-Density Lipoprotein Subclass Distribution Pattern and Adiposity-Associated Dyslipidemia in Postmenopausal Women J. Am. Coll. Nutr., February 1, 2000; 19(1): 23 - 30. [Abstract] [Full Text] [PDF]

				P. M. Clifton, M. Noakes, and P. J. Nestel LDL particle size and LDL and HDL cholesterol changes with dietary fat and cholesterol in healthy subjects J. Lipid Res., September 1, 1998; 39(9): 1799 - 1804. [Abstract] [Full Text]