© 1995 American Heart Association, Inc.
Articles |
The Role of Lipoprotein A-I and Lipoprotein A-I/A-II in Predicting Coronary Artery Disease
From the Atherosclerosis Research Unit (T.O., T.T.N., B.J.H., B.A.K.); Division of Endocrinology/Metabolism and Internal Medicine (T.O., T.T.N.); Division of Biostatistics, Department of Health Related Sciences (D.H., K.B.); and the Division of Cardiovascular Disease (B.A.K.), Mayo Clinic and Foundation, Rochester, Minn.
Correspondence to B.A. Kottke, Watson Clinic, PO Box 95000, 1600 Lakeland Hills Blvd, Lakeland, FL 33804-5000.
Abstract The aim of this study was to examine the role of HDL subparticles with apolipoprotein (apo) A-I alone (LpA-I) and with apoA-I and apoA-II (LpA-I/A-II) in predicting coronary artery disease. Concentrations of these HDL subparticles were compared in 184 subjects with angiographically confirmed significant coronary artery disease (>50% stenosis of at least one vessel) and 191 age- and sex-matched control subjects without clinical coronary artery disease. LpA-I and LpA-I/A-II were measured with magnetic beads coated with anti–apoA-II antibodies to separate particles containing apoA-II from plasma. Total plasma cholesterol and triglyceride levels were similar in both groups. Although subjects with coronary artery disease had lower HDL cholesterol, plasma apoA-I, LpA-I, and LpA-I/A-II than age- and sex-matched control subjects without coronary artery disease, plasma apoA-I was the best predictor of coronary artery disease. In conclusion, LpA-I and LpA-I/A-II are lower in subjects with coronary artery disease but do not add to plasma apoA-I in predicting the presence of coronary artery disease.
Key Words: lipids • lipoproteins • HDL • coronary artery disease
This article has been cited by other articles:
 |
|
 |
|
  R. S. Birjmohun, G. M. Dallinga-Thie, J. A. Kuivenhoven, E. S.G. Stroes, J. D. Otvos, N. J. Wareham, R. Luben, J. J.P. Kastelein, K.-T. Khaw, and S. M. Boekholdt Apolipoprotein A-II Is Inversely Associated With Risk of Future Coronary Artery Disease Circulation, October 30, 2007; 116(18): 2029 - 2035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Meisinger, H. Loewel, W. Mraz, and W. Koenig Prognostic value of apolipoprotein B and A-I in the prediction of myocardial infarction in middle-aged men and women: results from the MONICA/KORA Augsburg cohort study Eur. Heart J., February 1, 2005; 26(3): 271 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Frohlich and M. Dobiasova Fractional Esterification Rate of Cholesterol and Ratio of Triglycerides to HDL-Cholesterol Are Powerful Predictors of Positive Findings on Coronary Angiography Clin. Chem., November 1, 2003; 49(11): 1873 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.J. Packard Apolipoproteins: the new prognostic indicator? Eur. Heart J. Suppl., June 1, 2003; 5(suppl_D): D9 - D16. [Abstract] [PDF]
|
|
|
|
 |
|
 G. Luc, J.-M. Bard, J. Ferrieres, A. Evans, P. Amouyel, D. Arveiler, J.-C. Fruchart, P. Ducimetiere, and on behalf of the PRIME Study Group Value of HDL Cholesterol, Apolipoprotein A-I, Lipoprotein A-I, and Lipoprotein A-I/A-II in Prediction of Coronary Heart Disease: The PRIME Study Arterioscler. Thromb. Vasc. Biol., July 1, 2002; 22(7): 1155 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Montoya, A. Porres, S. Serrano, J. C. Fruchart, P. Mata, J. A. G. Gerique, and G. R. Castro Fatty acid saturation of the diet and plasma lipid concentrations, lipoprotein particle concentrations, and cholesterol efflux capacity Am. J. Clinical Nutrition, March 1, 2002; 75(3): 484 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E Roeters van Lennep, H.T. Westerveld, D.W. Erkelens, and E. E van der Wall Risk factors for coronary heart disease: implications of gender Cardiovasc Res, February 15, 2002; 53(3): 538 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Blanco-Vaca, J. C. Escola-Gil, J. M. Martin-Campos, and J. Julve Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein J. Lipid Res., November 1, 2001; 42(11): 1727 - 1739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. R. van Lennep, H. T. Westerveld, H. W. O. R. van Lennep, A. H. Zwinderman, D. W. Erkelens, and E. E. van der Wall Apolipoprotein Concentrations During Treatment and Recurrent Coronary Artery Disease Events Arterioscler. Thromb. Vasc. Biol., November 1, 2000; 20(11): 2408 - 2413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Anderson, E. C. Konz, and D. J. A. Jenkins Health Advantages and Disadvantages of Weight-Reducing Diets: A Computer Analysis and Critical Review J. Am. Coll. Nutr., October 1, 2000; 19(5): 578 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Mahley, J. Pépin, K. E. Palaoglu, M. J. Malloy, J. P. Kane, and T. P. Bersot Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase: high density lipoprotein characterization and gender-specific effects of apolipoprotein E genotype J. Lipid Res., August 1, 2000; 41(8): 1290 - 1301. [Abstract] [Full Text]
|
|
|
|
|
|
N. Mero, A. Van Tol, L. M. Scheek, T. Van Gent, C. Labeur, M. Rosseneu, and M-R. Taskinen Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: relations with lipid transfer proteins and LCAT activities J. Lipid Res., July 1, 1998; 39(7): 1493 - 1502. [Abstract] [Full Text]
|
|
|
|
|
|
P. Alaupovic, W. J. Mack, C. Knight-Gibson, and H. N. Hodis The Role of Triglyceride-Rich Lipoprotein Families in the Progression of Atherosclerotic Lesions as Determined by Sequential Coronary Angiography From a Controlled Clinical Trial Arterioscler. Thromb. Vasc. Biol., April 1, 1997; 17(4): 715 - 722. [Abstract] [Full Text]
|
|
|
|
|
|
B. Lamarche, S. Moorjani, P. J. Lupien, B. Cantin, P.-M. Bernard, G. R. Dagenais, and J.-P. Despres Apolipoprotein A-I and B Levels and the Risk of Ischemic Heart Disease During a Five-Year Follow-up of Men in the Quebec Cardiovascular Study Circulation, August 1, 1996; 94(3): 273 - 278. [Abstract] [Full Text]
|
|