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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:228-231.)
© 1995 American Heart Association, Inc.

Articles

The Role of Lipoprotein A-I and Lipoprotein A-I/A-II in Predicting Coronary Artery Disease

T. O'Brien; T. T. Nguyen; B. J. Hallaway; D. Hodge; K. Bailey; D. Holmes; B. A. Kottke

From the Atherosclerosis Research Unit (T.O., T.T.N., B.J.H., B.A.K.); Division of Endocrinology/Metabolism and Internal Medicine (T.O., T.T.N.); Division of Biostatistics, Department of Health Related Sciences (D.H., K.B.); and the Division of Cardiovascular Disease (B.A.K.), Mayo Clinic and Foundation, Rochester, Minn.

Correspondence to B.A. Kottke, Watson Clinic, PO Box 95000, 1600 Lakeland Hills Blvd, Lakeland, FL 33804-5000.

Abstract The aim of this study was to examine the role of HDL subparticles with apolipoprotein (apo) A-I alone (LpA-I) and with apoA-I and apoA-II (LpA-I/A-II) in predicting coronary artery disease. Concentrations of these HDL subparticles were compared in 184 subjects with angiographically confirmed significant coronary artery disease (>50% stenosis of at least one vessel) and 191 age- and sex-matched control subjects without clinical coronary artery disease. LpA-I and LpA-I/A-II were measured with magnetic beads coated with anti–apoA-II antibodies to separate particles containing apoA-II from plasma. Total plasma cholesterol and triglyceride levels were similar in both groups. Although subjects with coronary artery disease had lower HDL cholesterol, plasma apoA-I, LpA-I, and LpA-I/A-II than age- and sex-matched control subjects without coronary artery disease, plasma apoA-I was the best predictor of coronary artery disease. In conclusion, LpA-I and LpA-I/A-II are lower in subjects with coronary artery disease but do not add to plasma apoA-I in predicting the presence of coronary artery disease.

Key Words: lipids • lipoproteins • HDL • coronary artery disease

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