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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:185-189.)
© 1995 American Heart Association, Inc.

Articles

Dietary Fish Oil Supplementation Alters Leukocyte Function and Cytokine Production in Healthy Women

Julie M. W. Wallace; Eithne Turley; William S. Gilmore; John J. Strain

From the School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland.

Correspondence to William S. Gilmore, PhD, School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, UK.

Abstract The effect of low-dose fish oil supplementation on cytokines and white cell function in women was investigated. Thirty-three healthy, nonsmoking women entered the double-blind study. For 4 weeks, 2.4 g of either fish oil (n=16) or fish oil with vitamin E (n=17) was added daily to the subjects' otherwise unchanged diets. Venous blood samples were taken at the onset of the trial, after the supplementation period, and again after a 9-week washout period. Plasma levels of platelet-derived growth factor and myeloperoxidase were measured using immunoassays. The intracellular peroxidase content of white blood cells was measured using a staining technique. Platelet-derived growth factor levels were significantly lowered after supplementation (P.05). Intracellular peroxidase was increased (P.01), and extracellular myeloperoxidase levels were lowered (P.05). Taken together, these results suggest that the anti-inflammatory effect of fish oil may be due at least partly to alterations in white cell function and growth factor levels.

Key Words: atherosclerosis • inflammation • fish oil • cytokines • leukocytes

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