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(Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:2136-2141.)
© 1995 American Heart Association, Inc.

Articles

LDL Size and Subclass Pattern in Mexico City Residents and San Antonio Mexican Americans

Steven M. Haffner; Clicerio González; Heikki Miettinen; Barbara V. Howard; Michael P. Stern

From the Division of Clinical Epidemiology (S.M.H., H.M., M.P.S.), Department of Medicine, University of Texas Health Science Center at San Antonio; the Centro de Estudios en Diabetes (C.G.), American British Cowdray Hospital, Mexico City; and the Medlantic Research Institute (B.V.H.), Washington, DC.

Correspondence to Steven M. Haffner, MD, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78284-7873.

Abstract Recent studies suggest that a relative abundance of small dense LDL is a risk factor for coronary heart disease. We compared LDL size in Mexico City residents (n=191) and San Antonio Mexican Americans (n=282), two genetically similar populations that differ markedly in dietary behaviors: in Mexico City 62% of calories are from carbohydrate and 19% from fat, and in San Antonio 40% of calories are from carbohydrate and 40% from fat. Mean LDL size in Mexico City was 258.6±0.9 Å, and in San Antonio, 255.9±0.6 Å (P=.013). After adjustment for the higher triglyceride and lower HDL cholesterol levels (the two most important predictors of LDL size) in Mexico City, LDL size was significantly lower in San Antonio than in Mexico City by -8.33±0.84 Å (P<.001). Our data suggest that the higher triglyceride concentrations in Mexico City residents that are associated with a higher carbohydrate diet may not be associated with atherogenic changes in LDL.

Key Words: LDL composition • ethnicity • Mexican Americans • diet

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