© 1995 American Heart Association, Inc.
Articles |
Association of Postprandial Triglyceride and Retinyl Palmitate Responses With Asymptomatic Carotid Artery Atherosclerosis in Middle-aged Men and Women
The Atherosclerosis Risk in Communities (ARIC) Study
From the Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, Bethesda, Md (A.R.S.); the Departments of Biostatistics (L.E.C.) and Epidemiology (G.H., C.C.P.), University of North Carolina School of Public Health, Chapel Hill; and the Department of Medicine, Baylor College of Medicine, and The Methodist Hospital (W.P.), Houston, Tex.
Abstract Blood lipid alterations after a fatty meal may be
atherogenic, but there is little information regarding their
associations with disease independent of fasting lipids.
Asymptomatic atherosclerosis cases (n=229)
and 373 control subjects free of atherosclerosis, as
defined by carotid intima-media thickness on ultrasound images,
were given a fatty meal with vitamin A, followed by 3.5- and 8-hour
measurements of triglycerides (TGs), TG-rich lipoprotein
TGs, apoproteinB48, and retinyl palmitate. Among white men and women
but not among blacks, case status was associated with greater
postprandial responses of TGs and TG-rich lipoprotein TGs, but only in
nonobese persons (body mass index <30 kg/m2). The
associations were strong and significant after controlling for
coronary risk factors (odds ratio, 
2.0) and fasting TGs
(odds ratio, 1.5). Associations with other postprandial lipid
measurements did not persist after controlling for fasting lipids.
Elevated postprandial TGs appear to be an independent risk factor for
carotid intimal thickening in nonobese whites. The lack of such a
relation in obese subjects and the lipid profile they manifest suggest
that postprandial TGs must be accompanied by accumulation of TG-rich
lipoprotein remnants to be atherogenic.
Key Words: atherosclerosis • carotid artery diseases • lipoproteins
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