Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:1951-1957
© 1995 American Heart Association, Inc.
Articles |
In Vivo Effect of TGF-ß1
Enhanced Intimal Thickening by Administration of TGF-ß1 in Rabbit Arteries Injured With a Balloon Catheter
From the Second Department of Internal Medicine (T.K., K. Tamura, K. Takahashi, Y.S., N.M.) and the Second Department of Pathology (B.A.), School of Medicine, Chiba University, Chiba; the Kirin Brewery Co, Ltd (H.O.), Maebashi City; and the Department of Pathology, Osaka City University Medical School (N.K., M.U.), Osaka, Japan.
Correspondence to Tetsuto Kanzaki, MD, Second Department of Internal Medicine, School of Medicine, Chiba University, 1-8-1, Inohana, Chiba City 260, Japan.
Abstract The in vivo effect of transforming growth factor–ß1 (TGF-ß1) was studied in a model system in which arterial intimal thickening was induced by injury of rabbit arteries with a balloon catheter (BCI). Intimal area and its ratio to medial area in carotid arteries after BCI were significantly higher in rabbits treated with 10 µg/kg TGF-ß1 and 10 mg/kg aspirin IV QD (TGF-ß1 group) than in those treated with 10 mg/kg aspirin IV QD only (control group). Intimal cell numbers in the TGF-ß1 and control groups were not significantly different from each other, but matrix volume in the intimal layer was significantly higher in the TGF-ß1 group. By immunohistochemical and Northern blot analyses, the fibronectin content in carotid intimal and medial layers was greater in the TGF-ß1 group compared with that in the control group. Thus, in intimal thickenings induced by BCI, TGF-ß1 mainly enhanced the formation of matrix containing fibronectin. Moreover, the mRNAs of TGF-ß type I and type II receptors were detected in carotid arteries 7 and 14 days after, but not before, BCI. Thus, TGF-ß1 influences the process of intimal thickening induced by BCI through a receptor-mediated mechanism in vivo. The significance of this fact is discussed in relation to the development of atherosclerosis.
Key Words: TGF-ß1 • intimal thickening • balloon catheter injury • extracellular matrix • fibronectin
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