This Article Full Text Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Snel, Y. E.M. Articles by Koppeschaar, H. P.F. Search for Related Content PubMed PubMed Citation Articles by Snel, Y. E.M. Articles by Koppeschaar, H. P.F.

(Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:1543-1548.)
© 1995 American Heart Association, Inc.

Articles

Magnetic Resonance Imaging–Assessed Adipose Tissue and Serum Lipid and Insulin Concentrations in Growth Hormone–Deficient Adults

Effect of Growth Hormone Replacement

Yvonne E.M. Snel; Manorath E. Doerga; Robert-Jan M. Brummer; Pierre M.J. Zelissen; Hans P.F. Koppeschaar

From the Department of Endocrinology, University Hospital Utrecht, Utrecht, and the Department of Internal Medicine (R.-J.M.B.), University Hospital Maastricht, Maastricht, Netherlands.

Correspondence to H.P.F. Koppeschaar, Department of Endocrinology, University Hospital Utrecht, Postbox 85500, 3508 GA Utrecht, Netherlands.

Abstract The visceral and subcutaneous abdominal adipose tissue (AT) areas and the subcutaneous hip AT area were assessed by magnetic resonance imaging (MRI) in relation to serum lipid and plasma insulin levels in 12 growth hormone–deficient (GHD) adults before and after 6 months of replacement therapy with recombinant human growth hormone (rhGH) and in 12 healthy control subjects. Compared with control subjects, GHD patients had a significantly increased amount of visceral AT, which was inversely related with plasma HDL cholesterol and positively correlated with plasma triglyceride levels. Visceral AT was not associated with plasma total and LDL cholesterol or plasma insulin concentrations. GHD patients also had elevated serum total cholesterol, LDL cholesterol, and triglyceride levels compared with control subjects. After 6 months of rhGH replacement therapy the mean visceral, subcutaneous abdominal, and subcutaneous hip AT areas and serum concentration of total cholesterol decreased significantly, whereas serum HDL cholesterol concentration increased significantly. No significant correlations were found between changes in the amount of AT and changes in serum lipid and plasma insulin levels.

Key Words: adipose tissue • serum lipids • plasma insulin • magnetic resonance imaging • growth hormone–deficient adults

This article has been cited by other articles:

				A. R. Hoffman, C. J. Strasburger, A. Zagar, W. F. Blum, A. Kehely, and M. L. Hartman Efficacy and Tolerability of an Individualized Dosing Regimen for Adult Growth Hormone Replacement Therapy in Comparison with Fixed Body Weight-Based Dosing J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3224 - 3233. [Abstract] [Full Text] [PDF]

				T. B. Twickler, M. J. M. Cramer, G. M. Dallinga-Thie, M. J. Chapman, D. W. Erkelens, and H. P. F. Koppeschaar Adult-Onset Growth Hormone Deficiency: Relation of Postprandial Dyslipidemia to Premature Atherosclerosis J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2479 - 2488. [Full Text] [PDF]

				P. V. Carroll, E. R. Christ the members of Growth Hormone Research Soci, B. A. Bengtsson, L. Carlsson, J. S. Christiansen, D. Clemmons, R. Hintz, K. Ho, Z. Laron, P. Sizonenko, et al. Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 382 - 395. [Abstract] [Full Text]

				B. Capaldo, L. Patti, U. Oliviero, S. Longobardi, F. Pardo, F. Vitale, S. Fazio, F. Di Rella, B. Biondi, G. Lombardi, et al. Increased Arterial Intima-Media Thickness in Childhood-Onset Growth Hormone Deficiency J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1378 - 1381. [Abstract] [Full Text] [PDF]