© 1995 American Heart Association, Inc.
Articles |
Relation Between Cholesterol Ester Transfer Protein Activities and Lipoprotein Cholesterol in Patients With Hypercholesterolemia and Combined Hyperlipidemia
From the Center for Human Nutrition (F.T., G.L.V., S.M.G.) and Departments of Clinical Nutrition (G.L.V., S.M.G.), Internal Medicine (S.M.G.), and Biochemistry (S.M.G.), University of Texas Southwestern Medical Center, Dallas, and the Department of Internal Medicine (A.R.T.), College of Physicians and Surgeons, Columbia University Medical Center, New York, NY.
Correspondence to Gloria Lena Vega, PhD, Center for Human Nutrition, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Room Y3.206, Dallas, TX 75235-9052.
Abstract Cholesterol ester transfer protein (CETP) promotes the transfer of cholesterol esters among different lipoprotein classes–high-density lipoproteins (HDL), very-low-density lipoproteins, intermediate-density lipoproteins, and low-density lipoproteins (LDL). The current study was carried out to determine whether CETP activities are correlated with lipoprotein cholesterol levels in a large number of patients having elevated LDL cholesterol and normal triglycerides (hypercholesterolemia) and elevated LDL cholesterol and high triglycerides (combined hyperlipidemia). Compared with 50 normolipidemic male patients, 113 hypercholesterolemic patients had a 42% higher mean activity of CETP, and approximately 60% of these patients had CETP activities outside the normal range. A similar elevation of CETP was observed in 47 patients with combined hyperlipidemia. Furthermore, in those with combined hyperlipidemia, CETP activities were highly correlated with LDL cholesterol, non-HDL cholesterol, and non-HDL/HDL ratios. Similar high correlations were obtained by combining normotriglyceridemic patients with and without elevated LDL cholesterol. Since patients with elevated LDL cholesterol had a significantly lower mean level of HDL cholesterol, a high CETP activity also was related to a reduced HDL cholesterol level. Our results are consistent with this concept, although they do not constitute final proof that high CETP activities contribute to elevated cholesterol concentrations and reduced HDL cholesterol levels in patients with hypercholesterolemia and in those with combined hyperlipidemia.
Key Words: hypercholesterolemia • combined hyperlipidemia • cholesterol ester transfer protein
This article has been cited by other articles:
 |
|
 |
|
  A. Soro, M. Jauhiainen, C. Ehnholm, and M.-R. Taskinen Determinants of low HDL levels in familial combined hyperlipidemia J. Lipid Res., August 1, 2003; 44(8): 1536 - 1544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Le Goff, M. Guerin, L. Petit, M. J. Chapman, and J. Thillet Regulation of human CETP gene expression: role of SP1 and SP3 transcription factors at promoter sites -690, -629, and -37 J. Lipid Res., July 1, 2003; 44(7): 1322 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Berneis and R. M. Krauss Metabolic origins and clinical significance of LDL heterogeneity J. Lipid Res., September 1, 2002; 43(9): 1363 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Escolà-Gil, J. Julve, A. Marzal-Casacuberta, J. Ordóñez-Llanos, F. González-Sastre, and F. Blanco-Vaca ApoA-II expression in CETP transgenic mice increases VLDL production and impairs VLDL clearance J. Lipid Res., February 1, 2001; 42(2): 241 - 248. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Tholstrup, B. Sandstrom, A. Bysted, and G. Holmer Effect of 6 dietary fatty acids on the postprandial lipid profile, plasma fatty acids, lipoprotein lipase, and cholesterol ester transfer activities in healthy young men Am. J. Clinical Nutrition, February 1, 2001; 73(2): 198 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. W. Grandjean, S. F. Crouse, and J. J. Rohack Influence of cholesterol status on blood lipid and lipoprotein enzyme responses to aerobic exercise J Appl Physiol, August 1, 2000; 89(2): 472 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jansen, J. Lopez-Miranda, P. Castro, F. Lopez-Segura, C. Marin, J. M Ordovas, E. Paz, J. Jimenez-Pereperez, F. Fuentes, and F. Perez-Jimenez Low-fat and high-monounsaturated fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in young, healthy, normolipemic men Am. J. Clinical Nutrition, July 1, 2000; 72(1): 36 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Lewis-Barned, W. H. F. Sutherland, R. J. Walker, H. L. Walker, S. A. de Jong, E. A. Edwards, and V. H. Markham Plasma Cholesterol Esterification And Transfer, the Menopause, And Hormone Replacement Therapy in Women J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3534 - 3538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. P. Bersot, G. L. Vega, S. M. Grundy, K. E. Palaoglu, P. Atagündüz, S. Özbayrakçi, O. Gökdemir, and R. W. Mahley Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese Turkish population J. Lipid Res., March 1, 1999; 40(3): 432 - 438. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. Tahvanainen, P. Pajukanta, K. Porkka, S. Nieminen, L. Ikavalko, I. Nuotio, M.-R. Taskinen, L. Peltonen, and C. Ehnholm Haplotypes of the ApoA-I/C-III/A-IV Gene Cluster and Familial Combined Hyperlipidemia Arterioscler. Thromb. Vasc. Biol., November 1, 1998; 18(11): 1810 - 1817. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sasai, K. Okumura-Noji, T. Hibino, R. Ikeuchi, N. Sakuma, T. Fujinami, and S. Yokoyama Human cholesteryl ester transfer protein measured by enzyme-linked immunosorbent assay with two monoclonal antibodies against rabbit cholesteryl ester transfer protein: plasma cholesteryl ester transfer protein and lipoproteins among Japanese hypercholesterolemic patients Clin. Chem., July 1, 1998; 44(7): 1466 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bruce, D. S. Sharp, and A. R. Tall Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia J. Lipid Res., May 1, 1998; 39(5): 1071 - 1078. [Abstract] [Full Text]
|
|
|
|
|
|
L. Krimbou, M. Tremblay, H. Jacques, J. Davignon, and J. S. Cohn In vitro factors affecting the concentration of gamma-LpE ({gamma}-LpE) in human plasma J. Lipid Res., April 1, 1998; 39(4): 861 - 872. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Sugano, N. Makino, S. Sawada, S. Otsuka, M. Watanabe, H. Okamoto, M. Kamada, and A. Mizushima Effect of Antisense Oligonucleotides against Cholesteryl Ester Transfer Protein on the Development of Atherosclerosis in Cholesterol-fed Rabbits J. Biol. Chem., February 27, 1998; 273(9): 5033 - 5036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Tato, G. L. Vega, and S. M. Grundy Determinants of Plasma HDL-Cholesterol in Hypertriglyceridemic Patients: Role of Cholesterol-Ester Transfer Protein and Lecithin Cholesteryl Acyl Transferase Arterioscler. Thromb. Vasc. Biol., January 1, 1997; 17(1): 56 - 63. [Abstract] [Full Text]
|
|
|
|
|
|
B. Foger, A. Ritsch, A. Doblinger, H. Wessels, and J. R. Patsch Relationship of Plasma Cholesteryl Ester Transfer Protein to HDL Cholesterol: Studies in Normotriglyceridemia and Moderate Hypertriglyceridemia Arterioscler. Thromb. Vasc. Biol., December 1, 1996; 16(12): 1430 - 1436. [Abstract] [Full Text]
|
|
|
|
|
|
M. Guerin, E. Bruckert, P. J. Dolphin, G. Turpin, and M. J. Chapman Fenofibrate Reduces Plasma Cholesteryl Ester Transfer From HDL to VLDL and Normalizes the Atherogenic, Dense LDL Profile in Combined Hyperlipidemia Arterioscler. Thromb. Vasc. Biol., June 1, 1996; 16(6): 763 - 772. [Abstract] [Full Text]
|
|
|
|
|
|
G. L. Vega and S. M. Grundy Hypercholesterolemia With Cholesterol-Enriched LDL and Normal Levels of LDL–Apolipoprotein B : Effects of the Step I Diet and Bile Acid Sequestrants on the Cholesterol Content of LDL Arterioscler. Thromb. Vasc. Biol., April 1, 1996; 16(4): 517 - 522. [Abstract] [Full Text]
|
|
|
|
|
|
F. Tato, G. L. Vega, and S. M. Grundy Bimodal Distribution of Cholesteryl Ester Transfer Protein Activities in Normotriglyceridemic Men With Low HDL Cholesterol Concentrations Arterioscler. Thromb. Vasc. Biol., April 1, 1995; 15(4): 446 - 451. [Abstract] [Full Text]
|
|