Arteriosclerosis and Thrombosis, Vol 14, 840-856, Copyright © 1994 by American Heart Association

ARTICLES

A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association

HC Stary, AB Chandler, S Glagov, JR Guyton, W Insull Jr, ME Rosenfeld, SA Schaffer, CJ Schwartz, WD Wagner and RW Wissler
Office of Scientific Affairs, American Heart Association, Dallas, TX 75231-4596.

The compositions of lesion types that precede and that may initiate the development of advanced atherosclerotic lesions are described and the possible mechanisms of their development are reviewed. While advanced lesions involve disorganization of the intima and deformity of the artery, such changes are absent or minimal in their precursors. Advanced lesions are either overtly clinical or they predispose to the complications that cause ischemic episodes; precursors are silent and do not lead directly to complications. The precursors are arranged in a temporal sequence of three characteristic lesion types. Types I and II are generally the only lesion types found in children, although they may also occur in adults. Type I lesions represent the very initial changes and are recognized as an increase in the number of intimal macrophages and the appearance of macrophages filled with lipid droplets (foam cells). Type II lesions include the fatty streak lesion, the first grossly visible lesion, and are characterized by layers of macrophage foam cells and lipid droplets within intimal smooth muscle cells and minimal coarse-grained particles and heterogeneous droplets of extracellular lipid. Type III (intermediate) lesions are the morphological and chemical bridge between type II and advanced lesions. Type III lesions appear in some adaptive intimal thickenings (progression-prone locations) in young adults and are characterized by pools of extracellular lipid in addition to all the components of type II lesions.

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				References Circulation, December 17, 2002; 106(25): 3373 - 3421. [Full Text]

				V. V. Kunjathoor, M. Febbraio, E. A. Podrez, K. J. Moore, L. Andersson, S. Koehn, J. S. Rhee, R. Silverstein, H. F. Hoff, and M. W. Freeman Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages J. Biol. Chem., December 13, 2002; 277(51): 49982 - 49988. [Abstract] [Full Text] [PDF]

				T. Naruko, M. Ueda, K. Haze, A. C. van der Wal, C. M. van der Loos, A. Itoh, R. Komatsu, Y. Ikura, M. Ogami, Y. Shimada, et al. Neutrophil Infiltration of Culprit Lesions in Acute Coronary Syndromes Circulation, December 3, 2002; 106(23): 2894 - 2900. [Abstract] [Full Text] [PDF]

				M. Sandrock, D.-C. Cheng, D. Schmitz, and A. Schmidt-Trucksass Quantification of the Wall Inhomogeneity in B-mode Sonographic Images of the Carotid Artery J. Ultrasound Med., December 1, 2002; 21(12): 1395 - 1404. [Abstract] [Full Text] [PDF]

				M. Van Eck, I. S. T. Bos, W. E. Kaminski, E. Orso, G. Rothe, J. Twisk, A. Bottcher, E. S. Van Amersfoort, T. A. Christiansen-Weber, W.-P. Fung-Leung, et al. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues PNAS, April 30, 2002; 99(9): 6298 - 6303. [Abstract] [Full Text] [PDF]

				S. Lehto, L. Niskanen, M. Suhonen, T. Ronnemaa, P. Saikku, and M. Laakso Association Between Chlamydia pneumoniae Antibodies and Intimal Calcification in Femoral Arteries of Nondiabetic Patients Arch Intern Med, March 11, 2002; 162(5): 594 - 599. [Abstract] [Full Text] [PDF]

				V. V. Kunjathoor, D. S. Chiu, K. D. O'Brien, and R. C. LeBoeuf Accumulation of Biglycan and Perlecan, but Not Versican, in Lesions of Murine Models of Atherosclerosis Arterioscler Thromb Vasc Biol, March 1, 2002; 22(3): 462 - 468. [Abstract] [Full Text] [PDF]

				A. P. Burke, F. D. Kolodgie, A. Farb, D. Weber, and R. Virmani Morphological Predictors of Arterial Remodeling in Coronary Atherosclerosis Circulation, January 22, 2002; 105(3): 297 - 303. [Abstract] [Full Text] [PDF]

				P. M. McCabe, J. A. Gonzales, J. Zaias, A. Szeto, M. Kumar, A. J. Herron, and N. Schneiderman Social Environment Influences the Progression of Atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit Circulation, January 22, 2002; 105(3): 354 - 359. [Abstract] [Full Text] [PDF]

				L. Marcu, M. C. Fishbein, J.-M. I. Maarek, and W. S. Grundfest Discrimination of Human Coronary Artery Atherosclerotic Lipid-Rich Lesions by Time-Resolved Laser-Induced Fluorescence Spectroscopy Arterioscler Thromb Vasc Biol, July 1, 2001; 21(7): 1244 - 1250. [Abstract] [Full Text] [PDF]

				Q.-K. Tran, H. Watanabe, H.-Y. Le, L. Pan, M. Seto, K. Takeuchi, and K. Ohashi Myosin Light Chain Kinase Regulates Capacitative Ca2+ Entry in Human Monocytes/Macrophages Arterioscler Thromb Vasc Biol, April 1, 2001; 21(4): 509 - 515. [Abstract] [Full Text] [PDF]

				K. J. Clark, N. R. Cary, A. A. Grace, and J. C. Metcalfe Microsatellite Mutation of Type II Transforming Growth Factor-{beta} Receptor Is Rare in Atherosclerotic Plaques Arterioscler Thromb Vasc Biol, April 1, 2001; 21(4): 555 - 559. [Abstract] [Full Text] [PDF]

				S. Homma, N. Hirose, H. Ishida, T. Ishii, G. Araki, and J. H. Halsey Jr Carotid Plaque and Intima-Media Thickness Assessed by B-Mode Ultrasonography in Subjects Ranging From Young Adults to Centenarians Editorial Comment Stroke, April 1, 2001; 32(4): 830 - 835. [Abstract] [Full Text] [PDF]

				V. Papademetriou, P. Mammillot, R. Redman, A. Notargiacomo, P. Narayan, and R. Lakshman Prevention of atherosclerosis by specific AT1-receptor blockade with candesartan cilexetil Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S77 - S80. [Abstract] [PDF]

				Y. Miyao, K. Kugiyama, H. Kawano, T. Motoyama, H. Ogawa, M. Yoshimura, T. Sakamoto, and H. Yasue Diffuse intimal thickening of coronary arteries in patients with coronary spastic angina J. Am. Coll. Cardiol., August 1, 2000; 36(2): 432 - 437. [Abstract] [Full Text] [PDF]

				C.-J. Kim, J. C. Khoo, K. Gillotte-Taylor, A. Li, W. Palinski, C. K. Glass, and D. Steinberg Polymerase Chain Reaction-Based Method for Quantifying Recruitment of Monocytes to Mouse Atherosclerotic Lesions In Vivo : Enhancement by Tumor Necrosis Factor-{alpha} and Interleukin-1{beta} Arterioscler Thromb Vasc Biol, August 1, 2000; 20(8): 1976 - 1982. [Abstract] [Full Text] [PDF]

				H. C. Stary Natural History and Histological Classification of Atherosclerotic Lesions : An Update Arterioscler Thromb Vasc Biol, May 1, 2000; 20(5): 1177 - 1178. [Full Text] [PDF]

				R. Virmani, F. D. Kolodgie, A. P. Burke, A. Farb, and S. M. Schwartz Lessons From Sudden Coronary Death : A Comprehensive Morphological Classification Scheme for Atherosclerotic Lesions Arterioscler Thromb Vasc Biol, May 1, 2000; 20(5): 1262 - 1275. [Full Text] [PDF]

				P. Laine, A. Naukkarinen, L. Heikkila, A. Penttila, and P. T. Kovanen Adventitial Mast Cells Connect With Sensory Nerve Fibers in Atherosclerotic Coronary Arteries Circulation, April 11, 2000; 101(14): 1665 - 1669. [Abstract] [Full Text] [PDF]

				D. E. Vaughan AT1 Receptor Blockade and Atherosclerosis : Hopeful Insights Into Vascular Protection Circulation, April 4, 2000; 101(13): 1496 - 1497. [Full Text] [PDF]

				A. Orlandi, M. Marcellini, and L. G. Spagnoli Aging Influences Development and Progression of Early Aortic Atherosclerotic Lesions in Cholesterol-Fed Rabbits Arterioscler Thromb Vasc Biol, April 1, 2000; 20(4): 1123 - 1136. [Abstract] [Full Text] [PDF]

				W. B Strawn, R. H Dean, and C. M Ferrario Novel mechanisms linking angiotensin II and early atherogenesis Journal of Renin-Angiotensin-Aldosterone System, March 1, 2000; 1(1): 11 - 17. [PDF]

				M. O. Pentikainen, K. Oorni, and P. T. Kovanen Lipoprotein Lipase (LPL) Strongly Links Native and Oxidized Low Density Lipoprotein Particles to Decorin-coated Collagen. ROLES FOR BOTH DIMERIC AND MONOMERIC FORMS OF LPL J. Biol. Chem., February 25, 2000; 275(8): 5694 - 5701. [Abstract] [Full Text] [PDF]

				F. A Kummerow, Q. Zhou, and M. M Mahfouz Effect of trans fatty acids on calcium influx into human arterial endothelial cells Am. J. Clinical Nutrition, November 1, 1999; 70(5): 832 - 838. [Abstract] [Full Text] [PDF]

				B. WEITKAMP, P. CULLEN, G. PLENZ, H. ROBENEK, and J. RAUTERBERG Human macrophages synthesize type VIII collagen in vitro and in the atherosclerotic plaque FASEB J, August 1, 1999; 13(11): 1445 - 1457. [Abstract] [Full Text]

				G. Plenz, S. Reichenberg, C. Koenig, J. Rauterberg, M. C. Deng, H. A. Baba, and H. Robenek Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Modulates the Expression of Type VIII Collagen mRNA in Vascular Smooth Muscle Cells and Both Are Codistributed During Atherogenesis Arterioscler Thromb Vasc Biol, July 1, 1999; 19(7): 1658 - 1668. [Abstract] [Full Text] [PDF]

				P. G. Lysko, J. Weinstock, C. L. Webb, M. E. Brawner, and N. A. Elshourbagy Identification of a Small-Molecule, Nonpeptide Macrophage Scavenger Receptor Antagonist J. Pharmacol. Exp. Ther., June 1, 1999; 289(3): 1277 - 1285. [Abstract] [Full Text]

				D. Bonderman, E. Gharehbaghi-Schnell, G. Wollenek, G. Maurer, H. Baumgartner, and I. M. Lang Mechanisms Underlying Aortic Dilatation in Congenital Aortic Valve Malformation Circulation, April 27, 1999; 99(16): 2138 - 2143. [Abstract] [Full Text] [PDF]

				P. Laine, M. Kaartinen, A. Penttila, P. Panula, T. Paavonen, and P. T. Kovanen Association Between Myocardial Infarction and the Mast Cells in the Adventitia of the Infarct-Related Coronary Artery Circulation, January 26, 1999; 99(3): 361 - 369. [Abstract] [Full Text] [PDF]

				S. Ries, C. Büchler, T. Langmann, P. Fehringer, C. Aslanidis, and G. Schmitz Transcriptional regulation of lysosomal acid lipase in differentiating monocytes is mediated by transcription factors Sp1 and AP-2 J. Lipid Res., November 1, 1998; 39(11): 2125 - 2134. [Abstract] [Full Text]

				A. Miyazaki, N. Sakashita, O. Lee, K. Takahashi, S. Horiuchi, H. Hakamata, P. M. Morganelli, C. C. Y. Chang, and T.-Y. Chang Expression of ACAT-1 Protein in Human Atherosclerotic Lesions and Cultured Human Monocytes-Macrophages Arterioscler Thromb Vasc Biol, October 1, 1998; 18(10): 1568 - 1574. [Abstract] [Full Text] [PDF]

				J. Ravensbergen, J. W. Ravensbergen, J. K. B. Krijger, B. Hillen, and H. W. Hoogstraten Localizing Role of Hemodynamics in Atherosclerosis in Several Human Vertebrobasilar Junction Geometries Arterioscler Thromb Vasc Biol, May 1, 1998; 18(5): 708 - 716. [Abstract] [Full Text] [PDF]

				L. B. Nielsen, K. Juul, and B. G. Nordestgaard Increased Degradation of Lipoprotein(a) in Atherosclerotic Compared With Nonlesioned Aortic Intima–Inner Media of Rabbits : In Vivo Evidence That Lipoprotein(a) May Contribute to Foam Cell Formation Arterioscler Thromb Vasc Biol, April 1, 1998; 18(4): 641 - 649. [Abstract] [Full Text] [PDF]

				M.-L. M. Gronholdt, B. G. Nordestgaard, B. M. Wiebe, J. E. Wilhjelm, and H. Sillesen Echo-Lucency of Computerized Ultrasound Images of Carotid Atherosclerotic Plaques Are Associated With Increased Levels of Triglyceride-Rich Lipoproteins as Well as Increased Plaque Lipid Content Circulation, January 13, 1998; 97(1): 34 - 40. [Abstract] [Full Text] [PDF]

				J. R Oksenberg, G. T Stavri, M. C Jeong, Natara Garovoy, J. R Salisbury, and J. D Erusalimsky Analysis of the T-cell receptor repertoire in human atherosclerosis Cardiovasc Res, November 1, 1997; 36(2): 256 - 267. [Abstract] [Full Text] [PDF]

				W. G. Jerome and J. C. Lewis Cellular Dynamics in Early Atherosclerotic Lesion Progression in White Carneau Pigeons : Spatial and Temporal Analysis of Monocyte and Smooth Muscle Invasion of the Intima Arterioscler Thromb Vasc Biol, April 1, 1997; 17(4): 654 - 664. [Abstract] [Full Text]

				H.-I Yeh, E. Dupont, S. Coppen, S. Rothery, and N. J. Severs Gap Junction Localization and Connexin Expression in Cytochemically Identified Endothelial Cells of Arterial Tissue J. Histochem. Cytochem., January 1, 1997; 45(4): 539 - 550. [Abstract] [Full Text] [PDF]

				H. Wang, S. J. Germain, P. P. Benfield, and P. J. Gillies Gene Expression of Acyl Coenzyme A : Cholesterol Acyltransferase Is Upregulated in Human Monocytes During Differentiation and Foam Cell Formation Arterioscler Thromb Vasc Biol, June 1, 1996; 16(6): 809 - 814. [Abstract] [Full Text]

				H. Engelberg State-of the-Art Review : Endogenous Heparin Activity Deficiency and Atherosclerosis Clinical and Applied Thrombosis/Hemostasis, April 1, 1996; 2(2): 83 - 93. [PDF]

				L. B. Nielsen, S. Stender, K. Kjeldsen, and B. G. Nordestgaard Specific Accumulation of Lipoprotein(a) in Balloon-Injured Rabbit Aorta In Vivo Circ. Res., April 1, 1996; 78(4): 615 - 626. [Abstract] [Full Text]

				J. R. Guyton and K. F. Klemp Development of the Lipid-Rich Core in Human Atherosclerosis Arterioscler Thromb Vasc Biol, January 1, 1996; 16(1): 4 - 11. [Full Text]

				A.F. Drew and P.G. Tipping T Helper Cell Infiltration and Foam Cell Proliferation Are Early Events in the Development of Atherosclerosis in Cholesterol-Fed Rabbits Arterioscler Thromb Vasc Biol, October 1, 1995; 15(10): 1563 - 1568. [Abstract] [Full Text]

				H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull Jr, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis : A Report From the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association Arterioscler Thromb Vasc Biol, September 1, 1995; 15(9): 1512 - 1531. [Abstract] [Full Text]

				H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull Jr, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis : A Report From the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association Circulation, September 1, 1995; 92(5): 1355 - 1374. [Abstract] [Full Text]

				J. P. Blackburn, N. S. Peters, H.-I. Yeh, S. Rothery, C. R. Green, and N. J. Severs Upregulation of Connexin43 Gap Junctions During Early Stages of Human Coronary Atherosclerosis Arterioscler Thromb Vasc Biol, August 1, 1995; 15(8): 1219 - 1228. [Abstract] [Full Text]

				K. J. Williams and I. Tabas The Response-to-Retention Hypothesis of Early Atherogenesis Arterioscler Thromb Vasc Biol, May 1, 1995; 15(5): 551 - 561. [Full Text]

				A. Corsini, D. Verri, M. Raiteri, P. Quarato, R. Paoletti, and R. Fumagalli Effects of 26-Aminocholesterol, 27-Hydroxycholesterol, and 25-Hydroxycholesterol on Proliferation and Cholesterol Homeostasis in Arterial Myocytes Arterioscler Thromb Vasc Biol, March 1, 1995; 15(3): 420 - 428. [Abstract] [Full Text]

				M. Van Eck, I. S. T. Bos, W. E. Kaminski, E. Orso, G. Rothe, J. Twisk, A. Bottcher, E. S. Van Amersfoort, T. A. Christiansen-Weber, W.-P. Fung-Leung, et al. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues PNAS, April 30, 2002; 99(9): 6298 - 6303. [Abstract] [Full Text] [PDF]