Arteriosclerosis, Thrombosis, and Vascular Biology. 1994;14:701-706
Arteriosclerosis and Thrombosis, Vol 14, 701-706, Copyright © 1994 by American Heart Association
ARTICLES |
The association of hypotestosteronemia with coronary artery disease in men
GB Phillips, BH Pinkernell and TY Jing
Department of Medicine, Columbia University College of Physicians and Surgeons, St. Luke's-Roosevelt Hospital Center, New York, NY.
Hyperestrogenemia and hypotestosteronemia have been observed in association with myocardial infarction (MI) and its risk factors. To determine whether these abnormalities may be prospective for MI, estradiol and testosterone, as well as risk factors for MI, were measured in 55 men undergoing angiography who had not previously had an MI. Testosterone (r = -.36, P = .008) and free testosterone (r = -.49, P < .001) correlated negatively with the degree of coronary artery disease after controlling for age and body mass index. When the patient group was successively reduced to a final study group of 34 men by excluding the patients with other major disorders, the testosterone and free testosterone correlations persisted (r = -.43, P < .02 and r = - .62, P < .001, respectively). Neither estradiol nor the risk factors, except for high-density lipoprotein cholesterol, correlated with the degree of coronary artery disease in the final group. Testosterone correlated negatively with the risk factors fibrinogen, plasminogen activator inhibitor-1, and insulin and positively with high-density lipoprotein cholesterol. The correlations found in this study between testosterone and the degree of coronary artery disease and between testosterone and other risk factors for MI raise the possibility that in men hypotestosteronemia may be a risk factor for coronary atherosclerosis.
This article has been cited by other articles:
 |
|
 |
|
  A. M. Traish, F. Saad, R. J. Feeley, and A. Guay The Dark Side of Testosterone Deficiency: III. Cardiovascular Disease J Androl, September 1, 2009; 30(5): 477 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Tharp, I. Masseau, J. Ivey, V. K. Ganjam, and D. K. Bowles Endogenous testosterone attenuates neointima formation after moderate coronary balloon injury in male swine Cardiovasc Res, April 1, 2009; 82(1): 152 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Friedrich, H. Volzke, D. Rosskopf, A. Steveling, A. Krebs, M. Nauck, and H. Wallaschofski Reference Ranges for Serum Dehydroepiandrosterone Sulfate and Testosterone in Adult Men J Androl, November 1, 2008; 29(6): 610 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lehtonen, R. Huupponen, J. Tuomilehto, S. Lavonius, S. Arve, H. Isoaho, I. Huhtaniemi, and R. Tilvis Serum testosterone but not leptin predicts mortality in elderly men Age Ageing, July 1, 2008; 37(4): 461 - 464. [Full Text] [PDF]
|
|
|
|
|
|
S. V. Getov, R. W. Lee, F. Dockery, and C. Rajkumar Androgens, ageing and vascular function Age Ageing, July 1, 2008; 37(4): 361 - 363. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Basaria and A. S. Dobs Testosterone Making an Entry Into the Cardiometabolic World Circulation, December 4, 2007; 116(23): 2658 - 2661. [Full Text] [PDF]
|
|
|
|
|
|
K.-T. Khaw, M. Dowsett, E. Folkerd, S. Bingham, N. Wareham, R. Luben, A. Welch, and N. Day Endogenous Testosterone and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Men: European Prospective Investigation Into Cancer in Norfolk (EPIC-Norfolk) Prospective Population Study Circulation, December 4, 2007; 116(23): 2694 - 2701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Nettleship, T. H. Jones, K. S. Channer, and R. D. Jones Physiological Testosterone Replacement Therapy Attenuates Fatty Streak Formation and Improves High-Density Lipoprotein Cholesterol in the Tfm Mouse: An Effect That Is Independent of the Classic Androgen Receptor Circulation, November 20, 2007; 116(21): 2427 - 2434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Bowles, K. K. Maddali, V. C. Dhulipala, and D. H. Korzick PKC{delta} mediates anti-proliferative, pro-apoptic effects of testosterone on coronary smooth muscle Am J Physiol Cell Physiol, August 1, 2007; 293(2): C805 - C813. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Debing, E. Peeters, W. Duquet, K. Poppe, B. Velkeniers, and P. Van den Brande Endogenous sex hormone levels in postmenopausal women undergoing carotid artery endarterectomy Eur. J. Endocrinol., June 1, 2007; 156(6): 687 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bhasin, R. A. Parker, F. Sattler, R. Haubrich, B. Alston, T. Umbleja, C. M. Shikuma, and for the AIDS Clinical Trials Group Protocol A5079 Effects of Testosterone Supplementation on Whole Body and Regional Fat Mass and Distribution in Human Immunodeficiency Virus-Infected Men with Abdominal Obesity J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 1049 - 1057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Selvin, M. Feinleib, L. Zhang, S. Rohrmann, N. Rifai, W. G. Nelson, A. Dobs, S. Basaria, S. H. Golden, and E. A. Platz Androgens and Diabetes in Men: Results from the Third National Health and Nutrition Examination Survey (NHANES III) Diabetes Care, February 1, 2007; 30(2): 234 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wang, K. Lai, F. J. Moy, A. Bhat, H. B. Hartman, and M. J. Evans The Nuclear Hormone Receptor Farnesoid X Receptor (FXR) Is Activated by Androsterone Endocrinology, September 1, 2006; 147(9): 4025 - 4033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Braga-Basaria, A. S. Dobs, D. C. Muller, M. A. Carducci, M. John, J. Egan, and S. Basaria Metabolic Syndrome in Men With Prostate Cancer Undergoing Long-Term Androgen-Deprivation Therapy J. Clin. Oncol., August 20, 2006; 24(24): 3979 - 3983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Casquero, J. A. Berti, A. G. Salerno, E. J. B. Bighetti, P. M. Cazita, D. F. J. Ketelhuth, M. Gidlund, and H. C. F. Oliveira Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice J. Lipid Res., July 1, 2006; 47(7): 1526 - 1534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hougaku, J. L. Fleg, S. S. Najjar, E. G. Lakatta, S. M. Harman, M. R. Blackman, and E. J. Metter Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements Am J Physiol Endocrinol Metab, February 1, 2006; 290(2): E234 - E242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Kaufman and A. Vermeulen The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications Endocr. Rev., October 1, 2005; 26(6): 833 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-Y. Lin, Q. Xu, S. Yeh, R.-S. Wang, J. D. Sparks, and C. Chang Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor Diabetes, June 1, 2005; 54(6): 1717 - 1725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Phillips Is Atherosclerotic Cardiovascular Disease an Endocrinological Disorder? The Estrogen-Androgen Paradox J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2708 - 2711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A M Smith, K M English, C J Malkin, R D Jones, T H Jones, and K S Channer Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina Eur. J. Endocrinol., February 1, 2005; 152(2): 285 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Phillips The GILHT-E Syndrome? Diabetes Care, September 1, 2004; 27(9): 2285 - 2286. [Full Text] [PDF]
|
|
|
|
|
|
T. A. Henriques, J. Huang, S. S. D'Souza, A. Daugherty, and L. A. Cassis Orchidectomy, But Not Ovariectomy, Regulates Angiotensin II-Induced Vascular Diseases in Apolipoprotein E-Deficient Mice Endocrinology, August 1, 2004; 145(8): 3866 - 3872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Muller, A. W. van den Beld, M. L. Bots, D. E. Grobbee, S. W.J. Lamberts, and Y. T. van der Schouw Endogenous Sex Hormones and Progression of Carotid Atherosclerosis in Elderly Men Circulation, May 4, 2004; 109(17): 2074 - 2079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H. Mikulec, L. Holloway, R. E. Krasnow, H. Javitz, G. E. Swan, T. Reed, R. Marcus, and D. Carmelli Relationship of Endogenous Sex Hormones to Coronary Heart Disease: A Twin Study J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1240 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Charchar, M. Tomaszewski, B. Lacka, J. Zakrzewski, E. Zukowska-Szczechowska, W. Grzeszczak, and A. F. Dominiczak Association of the Human Y Chromosome with Cholesterol Levels in the General Population Arterioscler Thromb Vasc Biol, February 1, 2004; 24(2): 308 - 312. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. B. Phillips RE: "SHAVING, CORONARY HEART DISEASE, AND STROKE: THE CAERPHILLY STUDY" Am. J. Epidemiol., December 1, 2003; 158(11): 1123 - 1124. [Full Text] [PDF]
|
|
|
|
|
|
M. Muller, Y. T. van der Schouw, J. H. H. Thijssen, and D. E. Grobbee Endogenous Sex Hormones and Cardiovascular Disease in Men J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5076 - 5086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Nakamura, Y. Miki, T. Suzuki, T. Nakata, A. D. Darnel, T. Moriya, C. Tazawa, H. Saito, T. Ishibashi, S. Takahashi, et al. Steroid Sulfatase and Estrogen Sulfotransferase in the Atherosclerotic Human Aorta Am. J. Pathol., October 1, 2003; 163(4): 1329 - 1339. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.J. Malkin, P.J. Pugh, T.H. Jones, and K.S. Channer Testosterone for secondary prevention in men with ischaemic heart disease? QJM, July 1, 2003; 96(7): 521 - 529. [Full Text] [PDF]
|
|
|
|
|
|
S. Zaina, L. Pettersson, A. B. Thomsen, C.-M. Chai, Z. Qi, J. Thyberg, and J. Nilsson Shortened Life Span, Bradycardia, and Hypotension in Mice with Targeted Expression of an Igf2 Transgene in Smooth Muscle Cells Endocrinology, June 1, 2003; 144(6): 2695 - 2703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fukui, Y. Kitagawa, N. Nakamura, M. Kadono, S. Mogami, C. Hirata, N. Ichio, K. Wada, G. Hasegawa, and T. Yoshikawa Association Between Serum Testosterone Concentration and Carotid Atherosclerosis in Men With Type 2 Diabetes Diabetes Care, June 1, 2003; 26(6): 1869 - 1873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. C. W. Wu and A. von Eckardstein Androgens and Coronary Artery Disease Endocr. Rev., April 1, 2003; 24(2): 183 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. van den Beld, M. L. Bots, J. A. M. L. L. Janssen, H. A. P. Pols, S. W. J. Lamberts, and D. E. Grobbee Endogenous Hormones and Carotid Atherosclerosis in Elderly Men Am. J. Epidemiol., January 1, 2003; 157(1): 25 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Hak, J. C. M. Witteman, F. H. de Jong, M. I. Geerlings, A. Hofman, and H. A. P. Pols Low Levels of Endogenous Androgens Increase the Risk of Atherosclerosis in Elderly Men: The Rotterdam Study J. Clin. Endocrinol. Metab., August 1, 2002; 87(8): 3632 - 3639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zitzmann, R. Junker, A. Kamischke, and E. Nieschlag Contraceptive Steroids Influence the Hemostatic Activation State in Healthy Men J Androl, July 1, 2002; 23(4): 503 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Kenny, K. M. Prestwood, C. A. Gruman, G. Fabregas, B. Biskup, and G. Mansoor Effects of Transdermal Testosterone on Lipids and Vascular Reactivity in Older Men With Low Bioavailable Testosterone Levels J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2002; 57(7): M460 - 465. [Abstract] [Full Text]
|
|
|
|
|
|
A. M. Matsumoto Andropause: Clinical Implications of the Decline in Serum Testosterone Levels With Aging in Men J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2002; 57(2): M76 - 99. [Full Text]
|
|
|
|
 |
|
 A. Q. Ding and J. N. Stallone Testosterone-induced relaxation of rat aorta is androgen structure specific and involves K+ channel activation J Appl Physiol, December 1, 2001; 91(6): 2742 - 2750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zitzmann, M. Brune, B. Kornmann, J. Gromoll, S. von Eckardstein, A. von Eckardstein, and E. Nieschlag The CAG Repeat Polymorphism in the AR Gene Affects High Density Lipoprotein Cholesterol and Arterial Vasoreactivity J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4867 - 4873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. P. Deenadayalu, R. E. White, J. N. Stallone, X. Gao, and A. J. Garcia Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1720 - H1727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vermeulen Androgen Replacement Therapy in the Aging Male--A Critical Evaluation J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2380 - 2390. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yildirir, G. Kabakci, I. Can, and B. Erbas Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms Eur. Heart J., April 1, 2001; 22(7): 612 - 613. [PDF]
|
|
|
|
|
|
A. S. Dobs, P. S. Bachorik, S. Arver, A. W. Meikle, S. W. Sanders, K. E. Caramelli, and N. A. Mazer Interrelationships among Lipoprotein Levels, Sex Hormones, Anthropometric Parameters, and Age in Hypogonadal Men Treated for 1 Year with a Permeation-Enhanced Testosterone Transdermal System J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1026 - 1033. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Nathan, W. Shi, H. Dinh, T. K. Mukherjee, X. Wang, A. J. Lusis, and G. Chaudhuri Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase PNAS, March 1, 2001; (2001) 51003698. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Harman, E. J. Metter, J. D. Tobin, J. Pearson, and M. R. Blackman Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 724 - 731. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. G. Cohen, P. A. Lotufo, and J. E. Manson Testosterone and Cardiovascular Risk Factors Arch Intern Med, July 10, 2000; 160(13): 2064 - 2065. [Full Text] [PDF]
|
|
|
|
|
|
G.M.C. Rosano Androgens and coronary artery disease. A sex-specific effect of sex hormones? Eur. Heart J., June 1, 2000; 21(11): 868 - 871. [PDF]
|
|
|
|
|
|
S. Schuler-Luttmann, G. Monnig, A. Enbergs, H. Schulte, G. Breithardt, G. Assmann, S. Kerber, and A. von Eckardstein Insulin-Like Growth Factor-Binding Protein-3 Is Associated With the Presence and Extent of Coronary Arteriosclerosis Arterioscler Thromb Vasc Biol, April 1, 2000; 20 (4): e10 - e15. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Hayward, R. P. Kelly, and P. Collins The roles of gender, the menopause and hormone replacement on cardiovascular function Cardiovasc Res, April 1, 2000; 46(1): 28 - 49. [Full Text] [PDF]
|
|
|
|
 |
|
 D. C Gould, R. Petty, and H. S Jacobs For and against: The male menopause---does it exist? • For • Against BMJ, March 25, 2000; 320(7238): 858 - 861. [Full Text]
|
|
|
|
|
|
H. Teoh, A. Quan, and R. Y.K Man Acute impairment of relaxation by low levels of testosterone in porcine coronary arteries Cardiovasc Res, March 1, 2000; 45(4): 1010 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Webb, J. G. McNeill, C. S. Hayward, D. de Zeigler, and P. Collins Effects of Testosterone on Coronary Vasomotor Regulation in Men With Coronary Heart Disease Circulation, October 19, 1999; 100(16): 1690 - 1696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. McCrohon, W. Jessup, D. J. Handelsman, and D. S. Celermajer Androgen Exposure Increases Human Monocyte Adhesion to Vascular Endothelium and Endothelial Cell Expression of Vascular Cell Adhesion Molecule-1 Circulation, May 4, 1999; 99(17): 2317 - 2322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Alexandersen, J. Haarbo, I. Byrjalsen, H. Lawaetz, and C. Christiansen Natural Androgens Inhibit Male Atherosclerosis : A Study in Castrated, Cholesterol-Fed Rabbits Circ. Res., April 16, 1999; 84(7): 813 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. K. Toung, R. J. Traystman, P. D. Hurn, and V. M. Miller Estrogen-Mediated Neuroprotection After Experimental Stroke in Male Rats • Editorial Comment Stroke, August 1, 1998; 29(8): 1666 - 1670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Vagnini, S. Hill, J. Puvogel, and J. Puvogel The Use of Multisite High Resolution Arterial Imaging to Assess Arteriosclerosis Angiology, December 1, 1997; 48(12): 1023 - 1030. [Abstract] [PDF]
|
|
|
|
|
|
A. von Eckardstein, S. Kliesch, E. Nieschlag, A. Chirazi, G. Assmann, and H. M. Behre Suppression of Endogenous Testosterone in Young Men Increases Serum Levels of High Density Lipoprotein Subclass Lipoprotein A-I and Lipoprotein(a) J. Clin. Endocrinol. Metab., October 1, 1997; 82(10): 3367 - 3372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Herman, J. T.C. Robinson, R. J. McCredie, M. R. Adams, M. J. Boyer, and D. S. Celermajer Androgen Deprivation Is Associated With Enhanced Endothelium-Dependent Dilatation in Adult Men Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 2004 - 2009. [Abstract] [Full Text]
|
|
|
|
|
|
K. A. Roberts, M. M. Woo, and J. C. Rutledge Nitric Oxide Mediates LDL Uptake in the Artery Wall in Response to High Concentrations of 17ß-Estradiol Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 2123 - 2131. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Mulligan, A. Iranmanesh, M. L. Johnson, M. Straume, and J. D. Veldhuis Aging alters feed-forward and feedback linkages between LH and testosterone in healthy men Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1997; 273(4): R1407 - R1413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Phillips, B. H. Pinkernell, and T.-Y. Jing Relationship Between Serum Sex Hormones and Coronary Artery Disease in Postmenopausal Women Arterioscler Thromb Vasc Biol, April 1, 1997; 17(4): 695 - 701. [Abstract] [Full Text]
|
|
|
|
|
|
T. M. Chou, K. Sudhir, S. J. Hutchison, E. Ko, T. M. Amidon, P. Collins, and K. Chatterjee Testosterone Induces Dilation of Canine Coronary Conductance and Resistance Arteries In Vivo Circulation, November 15, 1996; 94(10): 2614 - 2619. [Abstract] [Full Text]
|
|
|
|
|
|
G. B. Phillips, B. H. Pinkernell, and T.-Y. Jing The Association of Hyperestrogenemia With Coronary Thrombosis in Men Arterioscler Thromb Vasc Biol, November 1, 1996; 16(11): 1383 - 1387. [Abstract] [Full Text]
|
|
|
|
|
|
L. L. Jeppesen, H. S. Jorgensen, H. Nakayama, H. O. Raaschou, T. S. Olsen, and K. Winther Decreased Serum Testosterone in Men With Acute Ischemic Stroke Arterioscler Thromb Vasc Biol, June 1, 1996; 16(6): 749 - 754. [Abstract] [Full Text]
|
|
|
|
|
|
P. Yue, K. Chatterjee, C. Beale, P. A. Poole-Wilson, and P. Collins Testosterone Relaxes Rabbit Coronary Arteries and Aorta Circulation, February 15, 1995; 91(4): 1154 - 1160. [Abstract] [Full Text]
|
|
|
|
|
|
L. Nathan, W. Shi, H. Dinh, T. K. Mukherjee, X. Wang, A. J. Lusis, and G. Chaudhuri Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase PNAS, March 13, 2001; 98(6): 3589 - 3593. [Abstract] [Full Text] [PDF]
|
|