Arteriosclerosis and Thrombosis, Vol 14, 686-693, Copyright © 1994 by American Heart Association

ARTICLES

Hemostatic factors in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

D Green, KJ Ruth, AR Folsom and K Liu
Department of Medicine, Northwestern University Medical School, Chicago, Ill.

Elevated levels of factor VII (FVII) and fibrinogen (Fb) have been reported as risk factors for coronary heart disease in middle-aged and older adults. The purpose of this study was to determine whether increased levels of these and other hemostatic factors (FVIII, von Willebrand factor [vWF]) were associated with other coronary risk factors in young adults participating in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Hemostatic factors were measured in 1724 participants aged 23 to 35 years who were roughly balanced by sex and race (black/white). Fb was greater in women than men (black, 288 versus 253 mg/dL; white, 267 versus 240 mg/dL; overall P < .05 by Scheffe multiple-comparison test), and FVIII and vWF were higher in blacks than in whites (FVIII in men, 103% versus 88%, and in women, 104% versus 91%; vWF in men, 114% versus 98%, and in women, 117% versus 99%; P < .05). The latter factors were lower in those with blood group O, but within each blood group (except group A), blacks had significantly higher levels of FVIII and vWF. Fb was positively correlated with body mass index (r = .27 to .48, P < .001), total cholesterol (r = .13 to .17, P < .05), and low-density lipoprotein cholesterol (r = .15 to .22, P < .01) in all groups and with blood pressure, triglycerides, and cigarette smoking in white men. FVII correlated positively with cholesterol (r = .12 to .29, P < .05) and triglycerides (r = .23 to .32, P < .001) in all groups and with low- density lipoprotein in whites.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				K. R. Viel, D. K. Machiah, D. M. Warren, M. Khachidze, A. Buil, K. Fernstrom, J. C. Souto, J. M. Peralta, T. Smith, J. Blangero, et al. A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels Blood, May 1, 2007; 109(9): 3713 - 3724. [Abstract] [Full Text] [PDF]

				A. Hozawa, D. R. Jacobs Jr., M. W. Steffes, M. D. Gross, L. M. Steffen, and D.-H. Lee Relationships of Circulating Carotenoid Concentrations with Several Markers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: The Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) Study Clin. Chem., March 1, 2007; 53(3): 447 - 455. [Abstract] [Full Text] [PDF]

				N. C. Sousa, J. M. Anicchino-Bizzacchi, M. F. Locatelli, V. Castro, and M. L. Barjas-Castro The relationship between ABO groups and subgroups, factor VIII and von Willebrand factor Haematologica, February 1, 2007; 92(2): 236 - 239. [Abstract] [Full Text] [PDF]

				A. Shankar, J. J. Wang, E. Rochtchina, and P. Mitchell Positive Association Between Plasma Fibrinogen Level and Incident Hypertension Among Men: Population-Based Cohort Study Hypertension, December 1, 2006; 48(6): 1043 - 1049. [Abstract] [Full Text] [PDF]

				B. Thyagarajan, D. R Jacobs, G. G Apostol, L. J Smith, C. E Lewis, and O D. Williams Plasma fibrinogen and lung function: the CARDIA Study Int. J. Epidemiol., August 1, 2006; 35(4): 1001 - 1008. [Abstract] [Full Text] [PDF]

				M. H. Criqui, V. Vargas, J. O. Denenberg, E. Ho, M. Allison, R. D. Langer, A. Gamst, W. P. Bundens, and A. Fronek Ethnicity and Peripheral Arterial Disease: The San Diego Population Study Circulation, October 25, 2005; 112(17): 2703 - 2707. [Abstract] [Full Text] [PDF]

				L. A. Bazzano, J. He, P. Muntner, S. Vupputuri, and P. K. Whelton Relationship between Cigarette Smoking and Novel Risk Factors for Cardiovascular Disease in the United States Ann Intern Med, June 3, 2003; 138(11): 891 - 897. [Abstract] [Full Text] [PDF]

				T. J. Tegos, E. Kalodiki, M. M. Sabetai, and A. N. Nicolaides The Genesis of Atherosclerosis and Risk Factors: A Review Angiology, February 1, 2001; 52(2): 89 - 98. [Abstract] [PDF]

				J. J. Stec, H. Silbershatz, G. H. Tofler, T. H. Matheney, P. Sutherland, I. Lipinska, J. M. Massaro, P. F.W. Wilson, J. E. Muller, and R. B. D'Agostino Sr Association of Fibrinogen With Cardiovascular Risk Factors and Cardiovascular Disease in the Framingham Offspring Population Circulation, October 3, 2000; 102(14): 1634 - 1638. [Abstract] [Full Text] [PDF]

				L. F. Bielak, G. G. Klee, P. F. Sheedy II, S. T. Turner, R. S. Schwartz, and P. A. Peyser Association of Fibrinogen With Quantity of Coronary Artery Calcification Measured by Electron Beam Computed Tomography Arterioscler Thromb Vasc Biol, September 1, 2000; 20(9): 2167 - 2171. [Abstract] [Full Text] [PDF]

				H. P. Kohler and P. J. Grant Plasminogen-Activator Inhibitor Type 1 and Coronary Artery Disease N. Engl. J. Med., June 15, 2000; 342(24): 1792 - 1801. [Full Text] [PDF]

				A. J. Siegel, M. B. Sholar, J. H. Mendelson, S. E. Lukas, M. J. Kaufman, P. F. Renshaw, J. C. McDonald, K. B. Lewandrowski, F. S. Apple, J. J. Stec, et al. Cocaine-Induced Erythrocytosis and Increase in von Willebrand Factor: Evidence for Drug-Related Blood Doping and Prothrombotic Effects Arch Intern Med, September 13, 1999; 159(16): 1925 - 1929. [Abstract] [Full Text] [PDF]

				S. L. Archer, D. Green, M. Chamberlain, A. R. Dyer, and K. Liu Association of Dietary Fish and n-3 Fatty Acid Intake With Hemostatic Factors in the Coronary Artery Risk Development in Young Adults (CARDIA) Study Arterioscler Thromb Vasc Biol, July 1, 1998; 18(7): 1119 - 1123. [Abstract] [Full Text] [PDF]

				D. Green, M. A. Chamberlain, K. J. Ruth, A. R. Folsom, and K. Liu Factor VII, Cholesterol, and Triglycerides: The CARDIA Study Arterioscler Thromb Vasc Biol, January 1, 1997; 17(1): 51 - 55. [Abstract] [Full Text]

				M. W. Mansfield, D. M. Heywood, and P. J. Grant Circulating Levels of Factor VII, Fibrinogen, and von Willebrand Factor and Features of Insulin Resistance in First-Degree Relatives of Patients With NIDDM Circulation, November 1, 1996; 94(9): 2171 - 2176. [Abstract] [Full Text]

				D. S. Sharp, R. D. Abbott, C. M. Burchfiel, B. L. Rodriguez, R. P. Tracy, K. Yano, and J. D. Curb Plasma Fibrinogen and Coronary Heart Disease in Elderly Japanese-American Men Arterioscler Thromb Vasc Biol, February 1, 1996; 16(2): 262 - 268. [Abstract] [Full Text]