Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Arteriosclerosis, Thrombosis, and Vascular Biology. 1994;14:395-400

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schwartz, R. S.
Right arrow Articles by Holmes, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schwartz, R. S.
Right arrow Articles by Holmes, D. R., Jr

Arteriosclerosis and Thrombosis, Vol 14, 395-400, Copyright © 1994 by American Heart Association

ARTICLES

Differential neointimal response to coronary artery injury in pigs and dogs. Implications for restenosis models

RS Schwartz, WD Edwards, KR Bailey, AR Camrud, MA Jorgenson and DR Holmes Jr
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905.

Neointimal hyperplasia occurs in the coronary arteries after percutaneous revascularization procedures and is a reparative response that frequently causes recurrent stenosis. Prior animal studies have shown that neointimal tissue thickness is proportional to the depth of arterial injury. Because animal models are increasingly used to test therapeutic strategies against restenosis, the purpose of this study was to evaluate the degree of neointimal thickening formed in the coronary arteries of pigs compared with dogs in response to severe injury. Fourteen coronary arteries in six mongrel dogs and 18 coronary arteries in nine pigs underwent severe arterial injury using tantalum metal coils delivered on oversized angioplasty balloons. Animals were killed after 4 weeks, and all coronary arteries were pressure perfusion fixed. Mean histological injury scores and neointimal thicknesses for dogs were 1.9 +/- 0.3 and 0.30 +/- 0.11, respectively, compared with 2.1 +/- 0.7 and 0.71 +/- 0.36 for pigs. Thus, there was significantly less neointimal thickening in dogs compared with pigs (P < .001) despite no differences in injury (P = NS). The neointimal thickening differences translated into significantly different percent area stenoses: 55 +/- 24% for pigs versus 27 +/- 13% for dogs (P < .001). Linear regression modeled neointimal thickness versus injury assessed by an ordinal injury score proportional to the depth of injury for each species. This analysis confirmed the differences across multiple injury levels. The slope of the regression line for dogs was small, suggesting that no relation may exist between injury and neointimal thickness in this species. The pig may be a more appropriate model for the study of the genesis of stenosing neointima.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
D. L. Tharp, I. Masseau, J. Ivey, V. K. Ganjam, and D. K. Bowles
Endogenous testosterone attenuates neointima formation after moderate coronary balloon injury in male swine
Cardiovasc Res, April 1, 2009; 82(1): 152 - 160.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
Y. Wang, M. Krishnamoorthy, R. Banerjee, J. Zhang, S. Rudich, C. Holland, L. Arend, and P. Roy-Chaudhury
Venous stenosis in a pig arteriovenous fistula model--anatomy, mechanisms and cellular phenotypes
Nephrol. Dial. Transplant., February 1, 2008; 23(2): 525 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
A. G. Touchard and R. S. Schwartz
Preclinical Restenosis Models: Challenges and Successes
Toxicol Pathol, January 1, 2006; 34(1): 11 - 18.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Y. Van Belleghem, R. G. Forsyth, K. Narine, A. Moerman, Y. Taeymans, and G. J. Van Nooten
Bovine glue (BioGlue) is catabolized by enzymatic reaction in the vascular dog model
Ann. Thorac. Surg., June 1, 2004; 77(6): 2177 - 2181.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
B Heublein, R Rohde, V Kaese, M Niemeyer, W Hartung, and A Haverich
Biocorrosion of magnesium alloys: a new principle in cardiovascular implant technology?
Heart, June 1, 2003; 89(6): 651 - 656.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. K. Karnik, B. S. Brooke, A. Bayes-Genis, L. Sorensen, J. D. Wythe, R. S. Schwartz, M. T. Keating, and D. Y. Li
A critical role for elastin signaling in vascular morphogenesis and disease
Development, March 2, 2003; 130(2): 411 - 423.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. Raymond, E. Sauvageau, I. Salazkin, E. Ribourtout, G. Gevry, and A.-C. Desfaits
Role of the Endothelial Lining in Persistence of Residual Lesions and Growth of Recurrences After Endovascular Treatment of Experimental Aneurysms
Stroke, March 1, 2002; 33(3): 850 - 855.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. Suzuki, G. Kopia, S.-i. Hayashi, L. R. Bailey, G. Llanos, R. Wilensky, B. D. Klugherz, G. Papandreou, P. Narayan, M. B. Leon, et al.
Stent-Based Delivery of Sirolimus Reduces Neointimal Formation in a Porcine Coronary Model
Circulation, September 4, 2001; 104(10): 1188 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. Arab, C. Bode, and C. Hehrlein
The radioactive stent -- any chance of a resurrection?
Eur. Heart J., August 1, 2001; 22(15): 1245 - 1247.
[Abstract] [PDF]

Home page
 StrokeHome page
A.-C. Desfaits, J. Raymond, and J. P. Muizelaar
Growth Factors Stimulate Neointimal Cells In Vitro and Increase the Thickness of the Neointima Formed at the Neck of Porcine Aneurysms Treated by Embolization • Editorial Comment
Stroke, February 1, 2000; 31(2): 498 - 507.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. J. Carter, D. Scott, L. Bailey, T. Hoopes, R. Jones, and R. Virmani
Dose-Response Effects of 32P Radioactive Stents in an Atherosclerotic Porcine Coronary Model
Circulation, October 5, 1999; 100(14): 1548 - 1554.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. Raymond, A. C. Desfaits, D. Roy, and J. P. Muizelaar
Fibrinogen and Vascular Smooth Muscle Cell Grafts Promote Healing of Experimental Aneurysms Treated by Embolization • Editorial Comment
Stroke, August 1, 1999; 30(8): 1657 - 1664.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. R Dashwood, P. Noertersheuser, M. Kirchengast, and K. Munter
Altered endothelin-1 binding following balloon angioplasty of pig coronary arteries: effect of the ETA receptor antagonist, LU 135252
Cardiovasc Res, August 1, 1999; 43(2): 445 - 456.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Kirchengast and K. Munter
Endothelin and restenosis
Cardiovasc Res, September 1, 1998; 39(3): 550 - 555.
[Full Text] [PDF]

Home page
 CirculationHome page
C. J. McKenna, S. E. Burke, T. J. Opgenorth, R. J. Padley, L. J. Camrud, A. R. Camrud, J. Johnson, P. J. Carlson, A. Lerman, D. R. Holmes Jr, et al.
Selective ETA Receptor Antagonism Reduces Neointimal Hyperplasia in a Porcine Coronary Stent Model
Circulation, June 30, 1998; 97(25): 2551 - 2556.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
T Ohno, D Gordon, H San, V. Pompili, M. Imperiale, G. Nabel, and E. Nabel
Gene therapy for vascular smooth muscle cell proliferation after arterial injury
Science, August 5, 1994; 265(5173): 781 - 784.
[Abstract] [PDF]


ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1994 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.