Arteriosclerosis and Thrombosis, Vol 13, 521-528, Copyright © 1993 by American Heart Association

ARTICLES

Increased postprandial lipemia in Apo A-IMilano carriers

L Calabresi, M Cassinotti, G Gianfranceschi, O Safa, T Murakami, CR Sirtori and G Franceschini
Center E. Grossi Paoletti, University of Milano, Italy.

Plasma lipid/lipoprotein changes were monitored after a fat load (65 g fat per square meter body surface area) in six carriers of the apolipoprotein A-IMilano (A-IM) variant and six age- and sex-matched control subjects. The magnitude of postprandial lipemia, calculated as the area under the curve (AUC) described by plasma triglyceride (TG) level versus time, was threefold higher in the A-IM carriers; however, after correction for the different baseline TG levels, it was similar to control subjects. Moreover, the magnitude of postprandial lipemia was positively correlated with baseline TG in both A-IM carriers (r = 0.77) and control subjects (r = 0.80), indicating that fasting TGs are a major determinant of postprandial response in all subjects. Postprandial lipemia was also inversely correlated with high density lipoprotein (HDL) and HDL2 cholesterol in both groups (A-IM, r = -0.81 and -0.79; control subjects, r = -0.87 and -0.94). Different from those in control subjects, the plasma apo A-I levels in the A-IM carriers decreased progressively while apo B increased up to 4 hours but decreased thereafter. Postprandial rises of low density lipoprotein TG but not of HDL-TG AUC were significantly higher in the A-IM carriers, even after normalization for the different fasting concentrations. These data show that the low plasma HDL levels of A-IM carriers, which are secondary to a primary structural alteration of the major HDL apolipoprotein, are associated with elevated fasting and postprandial TG levels and an anomalous postprandial redistribution of TG among lipoprotein classes.

This article has been cited by other articles:

				C. Marin, J. Lopez-Miranda, P. Gomez, E. Paz, P. Perez-Martinez, F. Fuentes, J. A. Jimenez-Pereperez, J. M. Ordovas, and F. Perez-Jimenez Effects of the human apolipoprotein A-I promoter G-A mutation on postprandial lipoprotein metabolism Am. J. Clinical Nutrition, August 1, 2002; 76(2): 319 - 325. [Abstract] [Full Text] [PDF]

				M. C. Mahaney, J. Blangero, D. L. Rainwater, G. E. Mott, A. G. Comuzzie, J. W. MacCluer, and J. L. VandeBerg Pleiotropy and Genotype by Diet Interaction in a Baboon Model for Atherosclerosis : A Multivariate Quantitative Genetic Analysis of HDL Subfractions in Two Dietary Environments Arterioscler Thromb Vasc Biol, April 1, 1999; 19(4): 1134 - 1141. [Abstract] [Full Text] [PDF]

				M. A. Ostos, J. Lopez-Miranda, J. M. Ordovas, C. Marin, A. Blanco, P. Castro, F. Lopez-Segura, J. Jimenez-Pereperez, and F. Perez-Jimenez Dietary fat clearance is modulated by genetic variation in apolipoprotein A-IV gene locus J. Lipid Res., December 1, 1998; 39(12): 2493 - 2500. [Abstract] [Full Text]

				E. Voyiaziakis, I. J. Goldberg, A. S. Plump, E. M. Rubin, J. L. Breslow, and L.-S. Huang ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice J. Lipid Res., February 1, 1998; 39(2): 313 - 321. [Abstract] [Full Text]

				J. Lopez-Miranda, J.M. Ordovas, M.A. Ostos, C. Marin, S. Jansen, J. Salas, A. Blanco-Molina, J.A. Jimenez-Pereperez, F. Lopez-Segura, and F. Perez-Jimenez Dietary Fat Clearance in Normal Subjects Is Modulated by Genetic Variation at the Apolipoprotein B Gene Locus Arterioscler Thromb Vasc Biol, September 1, 1997; 17(9): 1765 - 1773. [Abstract] [Full Text]