Donate Help Contact The AHA Sign In Home
American Heart Association
Arteriosclerosis, Thrombosis, and Vascular Biology
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Arteriosclerosis, Thrombosis, and Vascular Biology. 1993;13:1650-1653

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cadroy, Y.
Right arrow Articles by Sakariassen, K. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cadroy, Y.
Right arrow Articles by Sakariassen, K. S.

Arteriosclerosis and Thrombosis, Vol 13, 1650-1653, Copyright © 1993 by American Heart Association

ARTICLES

Human type II hyperlipoproteinemia enhances platelet-collagen adhesion in flowing nonanticoagulated blood

Y Cadroy, S Lemozy, A Diquelou, J Ferrieres, P Douste-Blazy, B Boneu and KS Sakariassen
Laboratoire d'Hemostase, Hopital Purpan, Toulouse, France.

We investigated the effects of high plasma lipid levels on platelet adhesion and platelet thrombus formation in nonanticoagulated human blood on collagen fibrils at an arterial wall shear rate of 2600 seconds-1. Nonanticoagulated blood was drawn directly at a flow rate of 10 mL/min for 3 minutes from an antecubital vein of patients with type IIa (n = 5) and type IIb (n = 4) hyperlipoproteinemia over purified human type III collagen fibrils that were positioned on a plastic coverslip in a parallel-plate perfusion chamber. Results were compared with those obtained in healthy individuals with normal lipid plasma levels (n = 9). Blood-collagen interactions were quantified by morphometry as platelet-collagen adhesion, thrombus volume, and fibrin deposition. Platelet-collagen adhesion in the two groups of patients was significantly higher than in healthy individuals (70.7 [61.2 to 82.0] and 70.3 [66.4 to 81.0] in types IIa and IIb patients, respectively, versus 51.2 [44.5 to 68.6] in control subjects; P < .05. All values are percent median [range]). In contrast, the thrombus volume was similar in the three groups (11.3 [8.0 to 13.0], 9.6 [6.4 to 15.3], and 10.2 [6.8 to 16.1] microns3/microns2 [range], respectively). Differences in fibrin deposition were not observed. Thus, it appears that platelet-collagen adhesion is augmented in patients with type IIa and IIb hyperlipoproteinemia, indicating that the process of thrombogenesis is hastened in these patients.


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. Pedreno, R. Fernandez, C. Cullare, A. Barcelo, M. A. Elorza, and C. de Castellarnau
Platelet Integrin {alpha}IIbß3 (GPIIb-IIIa) Is Not Implicated in the Binding of LDL to Intact Resting Platelets
Arterioscler Thromb Vasc Biol, January 1, 1997; 17(1): 156 - 163.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
H. E. Roald, T. Lyberg, H. Dedichen, M. Hamers, P. Kierulf, A.-B. Westvik, and K. S. Sakariassen
Collagen-Induced Thrombus Formation in Flowing Nonanticoagulated Human Blood From Habitual Smokers and Nonsmoking Patients With Severe Peripheral Atherosclerotic Disease
Arterioscler Thromb Vasc Biol, January 1, 1995; 15(1): 128 - 132.
[Abstract] [Full Text]


ATVB Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1993 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.