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Arteriosclerosis, Thrombosis, and Vascular Biology. 1993;13:1572-1579

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Arteriosclerosis and Thrombosis, Vol 13, 1572-1579, Copyright © 1993 by American Heart Association

ARTICLES

Aortic smooth muscle cells in a three-dimensional collagen lattice culture. Evidence for posttranslational regulation of collagen synthesis

B Redecker-Beuke, M Thie, J Rauterberg and H Robenek
Institute of Arteriosclerosis Research, University of Munster, FRG.

Aortic smooth muscle cells were cultivated as monolayers on plastic or within collagen lattices with low- and high-serum supplementation, and the expression of mRNAs specific for pro alpha 1 (I) and pro alpha 1 (III) collagen were studied by slot blot hybridization. The steady- state levels of pro alpha 1 (I) and pro alpha 1 (III) collagen mRNA of cells within collagen lattices were found to be higher than those grown on plastic, although the production of collagen was lower. The degradation of pro alpha 1 (I) and pro alpha 1 (III) collagen mRNAs as revealed in the presence of actinomycin D was not affected by culturing the cells within a collagen lattice. In vitro translation assays of mRNAs of monolayer- and lattice-cultured cells showed no differences in translatability. These data suggest the involvement of posttranslational control of collagen production in collagen lattice- cultured smooth muscle cells.


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